Corticosteroid therapy in central stromal keratitis.
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Biomedical subjects
Publications and source records attributed to S B Aronson.
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Steroid/antiinfective combinations have a number of advantages over the separate ingredients, but the possibility of complications has been a subject of concern. Based on data obtained from the files of eight pharmaceutical companies and the health registry records of the United Kingdom, Australia and New Zealand for the period 1964-1973, it is concluded that the statistical incidence of adverse reactions was no greater with the steroid/antiinfective combinations than with their separate ingredients. In addition, there was no increase in incidence of the reactions during the same period with combinations. These conclusions were borne out by adverse reaction data reported in the literature and in certain unpublished prospective clinical studies. It was not feasible to obtain data from ophthalmologists who may have observed adverse reactions, but not reported them. A critical evaluation by Dr. Philip Ellis follows the review.
A biomicroscopic method for evaluation of ocular and adnexal toxicity in the white rabbit has been developed. When compared to the Draize method, the biomicroscopic method demonstrates a greater spectrum of clinical signs allowing for better dose-response characteristics. This method was found to be both reproducible and easy to execute. The biomicroscopic method, by defining discrete anatomical entities, allows for a high degree of predictability as to severity of ocular and adnexal toxicity as well as the occurrence of permanent ocular injury.