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Biomedical subjects

S Asko-Seljavaara

Publications and source records attributed to S Asko-Seljavaara.

At least 109 records · Page 6Linked to original sources
PubMed1984

Microvascular free flaps in early reconstruction of burns in the hand and forearm. Case reports.

In the reconstructive plastic surgery a free flap provides a one-stage method to achieve an optimal functional an aesthetic result. We report five acute burns or early contractions of the hand and forearm with free-flap reconstruction. In each case an attempt was made to design the flap to restore missing tissue components. We used three different musculocutaneous free flaps and two free skin flaps: a latissimus dorsi, a rectus abdominis and a rectus femoris renervated musculocutaneous flap, as well as a dorsalis pedis and a horizontal fasciocutaneous upper arm flap. In all five cases, the hand and wrist showed early restoration of function.

Adult↗
PubMed1984

Panoramic zonography in evaluation of recurrent basal cell carcinoma of the face.

Nine patients with recurrent, facial basal cell carcinoma were followed up both clinically and radiographically using a panoramic technique. A cylindrical image track was used for panoramic radiography. Five patients had bony destruction due to tumour re-occurrence, four patients had bony defects caused by surgery. The confirmation of the results by surgery and/or follow-up shows that the spread of basal cell carcinoma into bone can be diagnosed using a panoramic technique.

Aged↗
PubMed1983

Adriamycin extravasation: surgical treatment and possible prevention of skin and soft-tissue injuries.

In a material consisting of approximately 6,000 injections of Adriamycin during a 2-year period, eleven moderate and five severe extravasation injuries have been observed. Even a small leakage of the drug may cause a permanent lesion. The most serious injuries were caused by large doses and on the dorsum of the hand. Plastic surgical operations were successfully performed in the severe cases. An active surgical intervention after primary neutralization of the extravasated Adriamycin is recommended.

Adult↗
PubMed1982

Extracellular matrix proteins of human epidermal keratinocytes and feeder 3T3 cells.

Cultures of human epidermal keratinocytes obtained from adult epidermis were initiated using irradiated BALB/3T3 cells as feeder layers. At different stages of confluence of the epidermal islands, feeder cells were removed and the extracellular matrix proteins of both pure component cells and cocultures were analyzed biochemically and by immunochemical methods and compared to those of skin fibroblasts of the same donors. The keratinocytes synthesized and secreted fibronectin and small amounts of laminin and type IV collagen. In addition, a nondisulfide-linked collagenous polypeptide (Mr = 120,000) was synthesized by the keratinocytes and was confined to the cell layers. Collagenous polypeptides with Mr = 120,000 were also synthesized by organ cultures of epidermal tissue and were detected in its acid or detergent extracts but again no secretion to culture medium was found. The Mr = 120,000 collagen had biochemical and immunological properties distinct from those of types I-V collagens. In immunofluorescence of keratinocyte cultures, fibronectin staining was prominent in the lining marginal cells of the expanding periphery of the epidermal cell islands but was not detected in the terminally differentiating cells in the upper layers of stratified colonies. Very little type IV collagen was found deposited in pericellular matrix form by the keratinocytes. In contrast, the mouse 3T3 feeder cells were found to produce both type IV collagen and laminin in addition to the previously identified connective tissue glycoproteins of fibroblasts, interstitial procollagens, and fibronectin. Basement membrane collagen of the 3T3 cells was found deposited as apparently unprocessed procollagen alpha 1(IV) and alpha 2(IV) chains. The production in culture conditions of basal lamina glycoproteins by the fibroblastic feeder cells may promote the attachment and growth of the cocultured keratinocytes.

Basement Membrane↗
PubMed1982

The exposed knee joint: five case reports.

In both emergency and chronically infected cases, the exposed knee joint cavity should be immediately covered using a simple method which provides well-vascularized elastic tissue over the joint. We used a gastrocnemius musculocutaneous or muscle flap over the exposed knee joint in three emergency cases of complex, massive avulsion injury of the lower extremity and in two infected cases. No infectious complications were observed, although ligament reconstructions were made under the transposed muscle in one and the same session.

Adolescent↗
PubMed1982

Latissimus dorsi musculocutaneous flap used as a pedicle or free microvascular graft.

In our experience with 28 latissimus dorsi (LD) island pedicle musculocutaneous flaps we found it to be the best method in breast, chest wall and axillary reconstructions. the flap can be also easily extended to the face and used reversed, to cover lumbar defects. In the series of 11 free microvascular composite tissue to vascularize and restore deep and extensive soft tissue defects in the lower extremity, in the forearm and in the face. If a neurosensory flap or reconstruction and reinnervation of muscles of the extremity is necessary other tissues than a LD flap should be chosen.

Adult↗
PubMed1981

Dissociation of suction blister roof epidermis with trypsin and desoxyribonuclease into viable single cells.

Human epidermis, obtained in vivo by the suction blister method, was dissociated with trypsin and desoxyribonuclease into a single-cell suspension. Autoradiographic analysis of the blister roof epidermis and of the epidermal cell suspension was performed to show that neither the suction procedure nor the enzymatic dissociation affected DNA synthesis of the epidermal cells.

Adult↗
PubMed1981

Management of massive defects of the abdominal wall.

Full-thickness abdominal wall defects are mainly traumatic or infectious in origin. After adequate resuscitation, treatment of associated visceral trauma, antibiotic therapy and careful debridement to vital tissues, primary repair of the abdominal wall should be carried out by simple methods by using synthetic mesh and/or split skin grafts. Local pedicle skin flaps or musculocutaneous flaps are advocated for secondary repair of the abdominal wall and also used in elective tumour surgery when total resection of the abdominal wall is indicated.

Abdominal Injuries↗
PubMed1980

The burned hand. Early treatment and surgery of scars and contractions.

Hand burns are common injuries in which early accurate diagnosis of the severity of the injury and active surgical treatment can save it or diminish the permanent disability caused by the thermal trauma. During the four year period of 1976--1979 we treated 45 patients with acute hand burns; secondary surgery was performed in 29 scarred and contracted hands. Deep dermal or subdermal (III degree) burns were either immediately excised to the vital tissue (within 6 hr postburn) or early afterwards (within 1--7 days post injury). The reconstruction of the excised areas was made by free skin grafting in 43 hands. If deep structures were exposed, subsequent reconstructions were used: local, groin, or free flaps. The aims in treatment of scarred hands were to restore function and to repair unstable scars. The following secondary procedures, often combined in a one-stage operation, were performed: scar excision and regrafting, web space correction, groin flap reconstruction, digital joint arthrodesis or capsulectomy, tendon transfer, and spherical osteotomy.

Adolescent↗
PubMed1979

Transposition of muscle flaps for covering exposed bone in the leg.

A muscle transposition technique for reconstruction of soft tissue loss and skin defects with exposed bone in the leg is described. Reconstruction with muscle flaps and freee skin grafts is a reliable and convenient one-stage operation. The gastrocnemius and soleus muscles were used to cover the upper and middle third of the leg. The method was used in 13 patients, and there were 3 failures in the series because of the impaired vascularity of the injuried leg. In 7 cases, including one failure, the soft tissue injury was associated with compound fractures. No functional disability was observed in the leg, ankle or foot after successful transposition of the muscle flap.

Adolescent↗
PubMed1975

Kidney tubular cell proliferation in burned mice.

Kidney tubular cell proliferation after a 17%, sublethal, third-degree burn injury in mice was studied in vivo using tritiated thymidine. Changes in cell morphology were also followed. Total incorporation of 3H-TdR in renal cells was measured and autoradiographic analyses of the tubular cells in the renal cortex and in the stratum subcorticale were made 2 hours to 30 days after the injury. After the second day postburn there was a 3.5-fold stimulation in the total incorporation of 3H-TdR in DNA, and an 18-fold increase in the labelling index of tubular cells. The majority of the labelled cells were proximal tubular cells. After the third day postburn a moderate increase in the labelling index (7.5-fold) was observed; 40% of the labelled cells were distal tubular cells. No morphological signs of frank necrosis of the tubular cells could be observed in the burned mice within 3 days postburn, which indicates that the stimulated proliferation of the kidney tubular cells was induced by minor reversible tubular cell damage during the first few hours postburn. It is suggested that the tubular cells loose their normal growth-inhibiting factors through an altered cell wall which results in an abnormal stimulation of cell growth 2 days later. These findings support the idea that there are abnormalities in the regulation of cell growth in several organs after burn injury; in some tissues--as in the kidney--this results in a temporary insufficiency of organ function.

Animals↗
PubMedDate not supplied

Cutaneous blood flow in the TRAM flap.

Changes in the cutaneous blood flow of the pedicled TRAM flap for breast reconstruction were studied in 15 patients with laser Doppler flowmetry (LDF) and transcutaneous oxygen tension (ptcO2). One patient was excluded from the study. The LDF value increased to 127 +/- 15% of the base line on the random and to 151 +/- 13% (p less than 0.01) on the axial side after dissection of the random side of the flap. Ligation of the deep inferior epigastric artery caused a decrease to 57 +/- 8% (p less than 0.001) on the random and to 78 +/- 11% on the axial side. The random side ptcO2 decreased from 48 +/- 2 mmHg [6.4 +/- 0.3 kPa] to 17 +/- 5 mmHg [2.3 +/- 0.7 kPa] (p less than 0.001) after dissection of the flap and remained near zero for one week. Eight patients developed minor cutaneous necrosis on the random side, probably because the superior epigastric system could not adequately nourish the TRAM flap. Low LDF and ptcO2 values after pedicle ligation and a negative response to oxygen stimulation predicted skin necrosis.

Abdominal Muscles↗