Search PubMed⌕ Search

Biomedical subjects

S Arita

Publications and source records attributed to S Arita.

At least 55 records · Page 3Linked to original sources
PubMed1996

Simple bone cysts treated by multiple drill-holes. 23 cysts followed 2-10 years.

We treated 23 simple bone cysts by the multiple drill-hole method and reviewed them a mean of 5 (2-10) years later. 11 cysts were located in the humerus, 9 in the femur, 2 in the tibia, and 1 in the pubis. The cysts recurred in 15 cases after the initial operation. 12 recurrent cysts were treated with reoperations. At the follow-up, good bone formation with no sign of recurrence was seen in 15 cases. A residual cyst was found in 8 cases, but further treatment was not considered necessary.

Adolescent↗
PubMed1996

[Quantitative analysis of glucose tolerance tests, responses using fuzzy inference].

The diagnose of diabetes mellitus is generally made by the Glucose Tolerance Test. The data of this test is composed of the blood glucose level and insulin level with 75 g glucose loading dose. The criteria for the diagnosis of diabetes is proposed by WHO. With these criteria, one person whose value of Blood Glucose (BG) is 201 mg/dl is diagnosed as diabetes mellitus and another whose value of BG is 199 is as Impaired Glucose Tolerance. In this paper, we quantitatively analyze the dynamical responses of glucose tolerance tests and propose a new diagnostic system for diabetes using a fuzzy inference.

Blood Glucose↗
PubMed1995

Amino acid phosphatase activity of alkaline phosphatase. A possible role of protein phosphatase.

Alkaline phosphatase (ALP) hydrolyzed phosvitin and amino acid phosphates demonstrating nonisotropy at different pH. Orthovanadate, a protein phosphatase inhibitor, more specifically inhibited the serine and tyrosine phosphatase activities of ALP than that of threonine phosphatase at concentrations > 0.1 mM or 0.01 mM, respectively. Calyculin A and okadaic acid at increased concentrations increased ALP amino acid phosphatase activity. Bisphosphonates, such as disodium-1-hydroxy-1-aminopropylidine-1,1-diphosphonate (APD) and ethane-1-hydroxy-1,1-diphosphonate (HEBP), at increased concentrations, inhibited ALP amino acid phosphatase activity. These results suggest that ALP may function as a protein phosphatase. In terms of protein kinase inhibitors, N-[2-(methylamino)ethyl]-5-isoquinolinesulfonamide, N-(6-aminoheyxl)-5-chloro-1-naphthalenesulfomide hydrochloride and 4',5,7-trihydroxyisoflavone had little effect on ALP amino acid phosphatase activity. Staurosporine slightly enhanced ALP serine and threonine phosphatase activities at a concentration of 0.1 mM. These results suggest that protein phosphatase activity does not depend on the protein kinase activity of ALP, since duality between the former and the latter is not supported. ALP may function less as a protein kinase than as a protein phosphatase. The coupling mechanism of phosphate dynamics may be regulated indirectly.

Alkaline Phosphatase↗
PubMed1995

Multiple neurilemmoma in both legs. A case report.

A Japanese man, who was 61 years of age, presented with multiple neurilemmoma in both legs which had arisen from different levels of both sciatic nerves. There were no clinical findings relating to von Recklinghausen's disease in the patient or his siblings. Multiple neurilemmoma may be the result of embryonic metameric anomalies. The condition may be distinguished from von Recklinghausen's disease by the distribution of the lesions and genetic analysis.

Humans↗
PubMed1995

Possible cardiac side effects of granisetron, an antiemetic agent, in patients with bone and soft-tissue sarcomas receiving cytotoxic chemotherapy.

The cardiac effect of granisetron, a selective 5-hydroxytryptamine3 receptor antagonist, on 12 patients with bone and soft-tissue sarcomas treated by cytotoxic chemotherapy consisting of multiple courses was examined. Of the 12 patients, 4 showed significant electrocardiographical changes, including sinus bradycardia, integral change of P-waves, junctional escape beat, and atrioventricular (AV) block with Wenckebach phenomenon, indicating stimulatory regulation of the vagus nerve. These changes were observed in each patient after several courses of chemotherapy but not in the first course. There was no correlation between the electrocardiographical changes and the chemotherapeutic agents used or the type of tumor present. A patient with osteosarcoma showed persistent bradycardia in three courses, all protocols of which contained high-dose methotrexate. From these findings we conclude that the cardiac responses may be due to stimulated activity of the vagal efferent nerve, which is regulated reflexly by afferent nerve activity suppressed by granisetron. On the other hand, the antiemetic efficacy of granisetron was satisfactory. These results suggest that careful observation of the heart is necessary when granisetron is used, especially for chemotherapy consisting of repeated multiple courses.

Adolescent↗
PubMed1995

Irregularity of the apophysis of the ischial tuberosity evaluated by magnetic resonance imaging.

OBJECTIVE: To report the findings of magnetic resonance imaging (MRI) in two cases of apophyseal irregularity of the ischial tuberosity. PATIENTS AND METHODS: The authors describe the MRI findings for two males who presented with pain of sudden onset in the buttock. Both patients were examined by radiography, MRI and computed tomography, and one underwent bone scanning. RESULTS: On T1-weighted images, signal intensity was decreased in both the apophysis and the body adjacent to it; however, the signal intensity on T2-weighted images was increased. These findings are consistent with avulsion fracture of the apophysis. CONCLUSION: The MRI findings in these cases may support the previously suggested hypothesis that apophyseal irregularity with characteristic radiographic changes over time is caused by avulsion fracture of the apophyseal line. The relation between the characteristic radiographic features and the structural changes associated with fracture in this condition is discussed.

Adolescent↗
PubMed1995

[The relationship between genotypes of HLA-DRB1 alleles and progression of bony destruction changes of rheumatoid arthritis].

The relationship between genotypes of HLA-DRB 1 alleles and the progression of bone destruction of RA patients was assessed. The genotypes of the HLA-DRB 1 alleles were determined in 329 Japanese patients with seropositive RNA by polymerase chain reaction and allele-specific oligonucleotide probe techniques. We regarded HLA-DRB 1* 0101, 0401, 0404, 0405, 1001 and 1402 as susceptible alleles of RA and classified the patients into three groups. The s/s group consisted of those with susceptible factors in both of the HLA-DRB 1 alleles. The s/n group was made up of those having one susceptible factor and one non-susceptible factor. The n/n group consisted of those possessing two non-susceptible factors. The grading of radiographic change that was evaluated by Larsen's criteria compared with the genotyped results. In the result, the median years taken to development to grade III, IV and V were significantly shorter in the s/s groups compared with that in the s/n and n/n groups. Thus, genotyping of HLA-DRB 1 can be a useful prognostic market in the progression of bone destruction of RA.

Adult↗
PubMed1995

[Combination effect of pirarubicin, ifosfamide, and vincristine sulfate in the treatment of advanced synovial sarcoma--report of a case].

Synovial sarcoma with pulmonary metastases appeared to be sensitive to multiagent chemotherapy of Pirarubicin, Ifosfamide, and Vincristine Sulfate. However, this chemotherapy regimen could not be continued because of severe hemorrhagic cystitis due to the toxicity of Ifosfamide. Even in the advanced stage, this multiagent chemotherapy would be useful for the treatment of synovial sarcoma, if hemorrhagic cystitis could be prevented.

Adult↗
PubMed1995

[Pharmacokinetic study of UFT in cancer patients receiving maintenance dialysis].

Six post-operative cancer patients receiving chronic dialysis (4 colorectal and 2 gastric cancer) were given daily UFT (300 mg/day tid). To determine the clearance of UFT with dialysis, the plasma concentration of tegafur, 5-FU and uracil were measured on the day with dialysis and without dialysis. The plasma concentrations of tegafur at 2 hours after oral administration of UFT showed no difference between the day with dialysis and without dialysis. The concentration of 5-FU on the next day with dialysis was almost same as that of the patients with normal renal function because of the clearance of 5-FU with dialysis, although that on the 2nd day after dialysis was higher than that with dialysis. It was difficult to compare the plasma concentrations of uracil, because they are different in each patient. Therefore, it was considered to be difficult to maintain the suitable plasma concentration of uracil. However, clearance of UFT with dialysis was good and no severe side effect was observed in administration of UFT. These data suggest that UFT can be useful drug for gastrointestinal cancer patients receiving dialysis in a post-operative adjuvant chemotherapy.

Adult↗
PubMed1994

Aetiology of a simple bone cyst. A case report.

We describe a simple bone cyst in a patient who had an osteoblastic lesion which had been discovered 1 1/2 years earlier. Curettage and drilling proved effective treatment. We suggest that increased regional blood flow, in association with bone formation, produces a hydrodynamic disorder followed by venous obstruction leading to the formation of a bone cyst.

Biopsy↗
PubMed1994

Fuzzy-logic control of blood pressure through enflurane anesthesia.

OBJECTIVE: The objective of our study was to construct a closed-loop blood pressure control system using fuzzy logic during enflurane anesthesia. METHODS: Direct systolic blood pressure (SBP), the input variable, was assessed by a special fuzzy-logic membership function--that is, a triangulate continuum of grades between 0 and 1. We also set up the output membership function for the inhaled enflurane concentration. Four fuzzy-rule maps, or matrices, which determined the relationship between the changes of input variables and output values, were constructed based on published anesthetic values. The first map was based on the end-tidal anesthetic concentration known to block an adrenergic response. The fourth map was derived from the anesthetic effective dose (AD95). Fuzzy inference, arrived at by using fuzzy logic, followed the minimum-maximum center of gravity method. Anesthetic control started with the first map and was maintained with the succeeding maps. RESULTS: During anesthesia, the SBP remained within +/- 20% of the preanesthetic SBPs in 82% of the fuzzy control cases and within 83% during manual control. The difference was not significant. CONCLUSION: The anesthetist's management of the administration of the inhaled anesthetic enflurane was imitated by fuzzy-logic control of the blood pressure.

Adult↗
PubMed1994

Rheumatoid-susceptible alleles of HLA-DRB1 are genetically recessive to non-susceptible alleles in the progression of bone destruction in the wrists and fingers of patients with RA.

OBJECTIVE: To assess the relationship between HLA-DRB1 genotypes and the progression of bone destruction in Japanese patients with RA. METHODS: The HLA-DRB1 alleles were determined by polymerase chain reaction and allele specific oligonucleotide probe techniques in 160 Japanese patients with RA. HLA-DR 0101, 0401, 0404, 0405, 1001 and 1402 were regarded as susceptible alleles of RA according to previous reports. Patients were classified into three groups (S/S, S/N and N/N group), based on the possession of two, one or no susceptible factor. The grading of radio-graphic changes in the wrists and fingers were evaluated by Larsen's criteria. The radiographic grades were first compared with the results of genotyping in the 160 cross sectional cases. A retrospective study was then conducted on a subgroup consisting of 57 cases taken from the 160 cases used for the cross sectional study. RESULTS: In the scatter diagram of the 160 cross sectional cases expressing the relationship between the stage of bone destruction and duration of RA, the regression line and the 95% confidence intervals separated the S/S group from the S/N and N/N groups in the early phase of development of bone destruction. In the retrospective study on the 57 cases the median years taken to development to stage V in the wrists after the onset of symptoms were 13.1 in the patients in the S/S group, 22.7 in the S/N group and 23.0 in the N/N group. The difference observed between the S/S and S/N group, and between the S/S and N/N group were statistically significant (p < 0.01), but that between the S/N and N/N groups was not. Thus the bone destruction in the wrists and fingers progressed more rapidly in the S/S group than in the S/N and N/N groups; and the rheumatoid susceptible alleles of HLA-DRB1 can be considered to be genetically recessive to the non-susceptible alleles in the progression of bone destructions in the wrists and fingers. CONCLUSION: Genotyping of HLA-DRB1 can be a useful prognostic marker in the early phase of RA.

Adult↗