Search PubMed⌕ Search

Biomedical subjects

S Arichi

Publications and source records attributed to S Arichi.

90 records · Page 5Linked to original sources
PubMed1981

[Pharmacological studies on prescription containing bupleuri radix. (III). Effects of Sairei-Toh on anti-inflammatory action of glucocorticoid (author's transl)].

Effects of a "kanpo" -prescription; Sairei-Toh on the antigranulomatous action of glucocorticoid were investigated using male rats. Sairei-Toh increased the activity of the antigranulomatous action of dexamethasone although treatment with only Sairei-Toh showed no significant antigranulomatous action, as compared with the controls. The granuloma formation was reduced by administration of dexamethasone 0.5 mg/kg/day and Sairei-Toh for 4 days to almost the same extent as seen with 1.5 mg/kg/day of dexamethasone. The concomitant administration of Sairei-Toh and dexamethasone slightly inhibited the increase in serum triglycerides as induced by dexamethasone but did not alter serum cholesterol levels. There was no apparent difference in body, adrenal and thymus weights between the rats treated with dexamethasone in combinations with Sairei-Toh and those treated with only dexamethasone.

Animals↗
PubMed1979

Clinical observations on several meridian loci in chronic hepatitis and liver cirrhosis in comparison with those in female neurovegetative disorder, pregnancy, and the steroid side-effects syndrome.

Patients with chronic hepatitis showed various grades of the pinch-pressure pain (P-p pain) at the right Ch'ü-Ch'üan (Li-8) locus. Sometimes the P-p pain also appeared at the left locus (Li-8) as well, but in such cases the tendency is towards a stronger reactivity at the right side than at the left, and the P-p pain does not appear at the left side alone. These findings offer a noticeable contrast to those seen in pregnant women and in steroid-treated patients affected with an obvious side effect where the stronger reactivity is to be seen at the left rather than at the right. The P-p pain grades were inclined to decrease in severe cases, especially in liver cirrhosis. In general, the variability of the P-p pain of grades correlated well with the process of the findings of the liver function test and of the chief subjective complaints. Therefore, the P-p pain test is useful for the diagnosis of chronic hepatitis. Regarding the grade distribution patterns of P-p pain at the Li-8, LI-4, LI-11, and SI-11 loci, patients with chronic hepatitis showed a pattern of higher grades of P-p pain reactivity at the right Li-8 and SI-11 loci, and at the left LI-4 and LI-11 loci, while patients with the so-called female neurovegetative disorder, pregnant women, and patients affected with steroid side-effects showed a perfectly reversed reactivity pattern. These findings can be useful for the differentiation between chronic hepatitis and those groups of diseases showing subjective signs deceptively similar to those of chronic hepatitis and those groups of diseases showing subjective signs deceptively similar to those of chronic hepatitis. The comparison of the skin temperature between the right and the left loci showed lower levels at the right than at the left, and the comparison of the skin pH between the both sides showed a more elevated level at the right than at the left. The mechanisms of these phenomena are discussed and what seems to be the most appropriate explanation at present is offered.

Acupuncture Therapy↗
PubMedDate not supplied

Biopharmaceutical studies on crude drug preparations. I: Permeation of paeonol in a decoction and dry extract of Paeonia suffruticosa root cortex using an absorption simulator.

The permeation behavior of paeonol, one active constituent of a crude Chinese drug called Moutan Cortex, through an artificial gastric lipid barrier was examined in vitro using an absorption simulator in order to clarify how the administered form influenced the bioavailability of paeonol from a crude preparation. Paeonol concentrations were determined by a high-performance liquid chromatographic method developed during this study. Paeonol showed greater permeation from artificial gastric juice into artificial plasma when it was applied as a decoction or freeze-dried extract of Moutan Cortex than when applied as purified paeonol alone.

Absorption↗
PubMedDate not supplied

Effects of phenolic constituents from the mulberry tree on arachidonate metabolism in rat platelets.

The effects of various phenolic compounds isolated from the rootbark of the mulberry tree on rat platelet cyclooxygenase and lipoxygenase products formed from (1-14C)arachiodonic acid were studied. Kuwanons G and H, sanggenon C, and mulberrofuran Q at concentrations of 10(-3) to 10(-4)M inhibited the formation of 12-hydroxy-5,8,10-heptadecatrienoic acid (HHT) and thromboxane B2 (cyclooxygenase products); however, they increased the formation of 12-hydroxy-5,8,10,14-eicosatetraenoic acid (12-HETE) (a lipoxygenase product). Sanggenon D and mulberrofuran J at concentration of 10(-3)M inhibited the formation of HHT, thromboxane B2, and 12-HETE. Mulberrofuran G at a concentration of 10(-3)M inhibited the formation of HHT, thromboxane B2, and 12-HETE, while at 10(-5)M, it inhibited the formation of 12-HETE without affecting the formations of HHT and thromboxane B2. Kuwanon M and mulberroside A did not affect arachidonate metabolism in rat platelets.

Animals↗
PubMedDate not supplied

Studies on the activities of tannins and related compounds, X. Effects of caffeetannins and related compounds on arachidonate metabolism in human polymorphonuclear leukocytes.

As part of a series of biological examinations of various tannins and related compounds, the present paper reports the effects of caffeetannins and related compounds isolated from medicinal plants on arachidonate metabolism in human peripheral polymorphonuclear leukocytes (PMN-L). The formation of leukotriene B4 (LTB4) induced by calcium ionophore A 23187 (A 23187) in human PMN-L was inhibited by 3,5-, 4,5-, and 3,4-di-O-caffeoylquinic acid, caffeoylmalic acid, caffeoyltartric acid, rosmarinic acid, and caffeic acid. Rosmarinic acid strongly inhibited the formation of 5-hydroxy-6,8,11,14-eicosatetraenoic acid (5-HETE) and LTB4 (5-lipoxygenase products) at concentrations of 10(-5)-10(-3) M. On the other hand, the formation of prostaglandin E2 (PGE2) was enhanced in a concentration-dependent fashion by caffeic acid, caffeoylmalic acid, caffeoyltartaric acid, and 3,4-di-O-caffeoylquinic acid. On the basis of experimental results, it seems likely that caffeoyl derivatives could be developed as therapeutic drugs for treatment of allergic inflammation such as asthma.

Arachidonic Acid↗
PubMedDate not supplied

Inhibitory effects of various flavonoids isolated from leaves of persimmon on angiotensin-converting enzyme activity.

The leaves of the persimmon Diospyros kaki, have been traditionally used for treatment of hypertensive diseases in Japan. We have studied the inhibitory effects of four flavonoids isolated from the leaves of the persimmon on angiotensin-converting enzyme activity. The four flavonoids astragalin [1], kaempferol-3-O-(2"-O-galloyl)-glucoside [2], isoquercitrin [3], and quercetin-3-O-(2"-O-galloyl)-glucoside [4] inhibited the angiotensin-converting enzyme activity in a dose-dependent fashion. Compounds 1-4 produced 67%, 53%, 33%, and 48% inhibition at a concentration of 300 micrograms/ml, respectively. The 50% inhibitory concentrations (IC50) of 1 and 2 for the angiotensin-converting enzyme were 180 micrograms/ml and 280 micrograms/ml, respectively. On the other hand, 2 and 4 were shown to have tannin activities, but 1 and 3 had no tannin activities. These results suggest that there is no relationship between the inhibition for angiotensin converting enzyme activity and the tannin activity for the four flavonoids.

Angiotensin-Converting Enzyme Inhibitors↗