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Biomedical subjects

S Archer

Publications and source records attributed to S Archer.

At least 127 records · Page 7Linked to original sources
PubMed1976

The effect of anaesthesia of the airway in dog and man: a study of respiratory reflexes, sensations and lung mechanics.

1. The effect of breathing an anaesthetic aerosol of 5% bupivacaine hydrochloride has been assessed in dog and man. 2. In the dog, the cough reflex was abolished and the Hering-Breuer inflation reflex severely impaired or abolished; breathing became slower and deeper; no pathological changes were found in the lungs of these dogs. 3. In man, no untoward effects resulted from a 10 min period of aerosol inhalation; there were no systematic effects on airway resistance or lung volumes and the cough reflex in response to either tactile or chemical (citric acid aerosol) stimulation was invariably abolished. The Hering-Breuer inflation reflex was impaired, but this was not associated with any change in resting ventilation. The Ve/CO2 response was enhanced after aerosol anaesthesia; subjects felt an exaggerated dyspnoea. The aerosol anaesthesia abolished the afferent pathway of a reflexly elicited bronchoconstriction in one subject. There was no effect on the ability to hold the breath, or on the quality of the associated sensation. 4. Control aerosols of sodium chloride solution or phosphate buffer produced no effects. Control experiments with intravenous infusions of bupivacaine proved that none of the effects could have been produced by systemic effects of the absorbed anaesthetic. 5. Plasma concentrations of bupivacaine in man did not exceed a recognized toxic level. The experiments demonstrate a safe reversible anaesthesia of the airways in man lasting for a period of 10-20 min.

Aerosols↗
PubMed1975

Emetic activity of N-substituted norapomorphines.

Norapomorphine and ten of its N-substituted derivatives were prepared by modifications of procedures described earlier. In a dog emesis test the N-ethyl and N-n-propyl compounds had minimum effective doses of 0.00025 and 0.0005 mg/kg, respectively, when administered iv, sc, or im. In a modified Irwin mouse profile screen the minimum effective iv dose was 0.013 mg/kg for the N-ethyl and 0.0024 mg/kg for the N-n-propyl compound; percutaneous absorption was also observed in mice. All compounds examined caused the stereotyped apomorphine behavior syndrome but hypotensive effects were not serious.

Animals↗
PubMed1969

Total synthesis of dl-19-nor-16,17-dehydroprogesterone.

dl-2-(7,11-Dimethyl-3,7,11 - trans,trans-dodecatrienyl)-3-methyl-cyclopent-2-enol was prepared by reduction of the corresponding ketone. This tetraenol, on treatment with trifluoroacetic acid, underwent stereoselective cyclization to give dl-3,17-dimethyl-A-nor-D-homoestra-3,16-diene. This tetracyclic material was readily converted, by oxidative cleavage to the bicyclic triketo aldehyde followed by a double aldol cyclization, into dl-19-nor-16,17-dehydroprogesterone.

Chemical Phenomena↗