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Biomedical subjects

S Arase

Publications and source records attributed to S Arase.

81 records · Page 5Linked to original sources
PubMed1985

Sunscreens block the induction of unscheduled DNA synthesis and the inhibition of DNA synthesis by UV-B radiation in normal human fibroblasts. A new way of evaluating sunscreen efficacy in vitro.

In order to evaluate the photoprotective efficacy of sunscreens against the chronic actinic damage, we tested 3 sunscreens for their ability to reduce the induction of unscheduled DNA synthesis (UDS) and to prevent the inhibition of semi-conservative DNA synthesis by medium wavelength ultraviolet (UV-B) radiation in the normal human cultured fibroblasts in vitro. The values obtained are correlated with the sun protection factors (SPF) expressing the erythema inhibition in normal human skin. All sunscreens tested showed a protective effect. The protective factor for the induction of UDS is 10.1 for Spectraban 15 (SPF 15), 3.6 for Spectraban 5.6 (SPF 5.6) and 1.9 for 2.5% Indomethacin solution, whereas the protective factor for the inhibition of semi-conservative DNA synthesis of 15.2, 3.9 and 2.1 for each sunscreen was evaluated. These methods seem to be useful as a screening procedure for the evaluation of sunscreen effectiveness against chronic actinic skin damage including light induced skin malignancies.

4-Aminobenzoic Acid↗
PubMed1980

Nevoid basal cell epithelioma syndrome in Japan.

A 49-year-old Japanese man with typical features of nevoid basal cell epithelioma syndrome is reported. The patient had cystic lesions of the jaw bone, multiple basal cell epitheliomas of the scalp and face, pits on the palms and soles, bifid ribs, scoliosis and calcification of the falx cerebri. In Japan five certain cases have been reported previously. We added one new case and reviewed the other five cases briefly.

Basal Cell Nevus Syndrome↗
PubMed1980

Bloom's syndrome in a Japanese boy with lymphoma.

A 14-year-old boy with malignant lymphoma was identified as having Bloom's syndrome after he was shown to display a characteristically elevated frequency of spontaneous sister-chromatid exchanges. Frequencies of sister-chromatid exchanges per nucleus were 80.7 in blood lymphocytes and 29.9 in dermal fibroblasts. Clinical features, although suggestive of Bloom's syndrome, were not clear enough to permit the diagnosis. This is the first confirmed case of this rare genetic disorder in Japan, and in Asia.

Abnormalities, Multiple↗