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S Anttila

Publications and source records attributed to S Anttila.

84 records · Page 5Linked to original sources
PubMed1988

Bronchiolo-alveolitis with pulmonary basal lamina injury in a rheumatoid patient during gold treatment.

A 47-year-old housewife presented with nonproductive cough, progressive breathlessness and intermittent fever during gold treatment, originally prescribed for seropositive polyarthritis, which later fulfilled the criteria for systemic lupus erythematosus (SLE). An open lung biopsy showed abundant interstitial edema with mononuclear inflammatory cells and some eosinophils, and slight bronchiolitis. The picture was nonspecific but suggestive of hypersensitivity pneumonitis. Electron microscopy revealed splitting and local disappearance of the basal laminae of the alveolar capillaries, venules and alveolar epithelium. This injury was confirmed by immunohistochemical staining for type IV collagen and laminin, the major components of basal laminae. In most macrophages there was lysosomal electron dense granular material, i.e. aurosomes, which gave the spectrum of gold in electron microprobe analysis. After the gold treatment was stopped the pulmonary symptoms gradually decreased during several months and no permanent lung disease remained. Whereas the pulmonary manifestation could have been due to her underlying disease we discuss in this study the possibility of its being gold induced.

Alveolitis, Extrinsic Allergic↗
PubMed1988

Bronchial stenosis after aspiration of an iron tablet.

Stenosis of the right intermediate bronchus was found in a 60-year-old woman four months after aspiration of an iron tablet. Right middle and lower lobe lobectomies were performed. By light microscopy, small amounts of foreign, iron-positive material surrounded by giant cells, large collections of hemosiderin containing macrophages, and severe fibrosis with only minimal inflammation were observed in the bronchial wall. Early diagnosis and management are stressed in order to avoid the stenosing process which is also possible after aspiration of some tablets.

Bronchitis↗
PubMed1988

Diuretics and hyperuricemia in the elderly.

Serum uric acid (SUA) was studied in a rural population of 420 males and 592 females aged 65 years or more. The mean SUA concentration was 0.313 mmol/l in males and 0.316 mmol/l in females. In males, 47 (11.2%) and in females 60 (10.1%) had a SUA level of 0.42 mmol/l or more. Both the mean serum values and the frequency of hyperuricemia were higher than 11 years earlier in another, similar study. The SUA concentration was 0.361 mmol/l in the 435 individuals using diuretics and 0.281 mmol/l in the remaining 578. Of the 107 hyperuricemic individuals, 82% used diuretics, and only 2 out of those 20 where the SUA level was 0.50 mmol/l or more did not use diuretics. Apart from diuretics, only the serum creatinine concentration, the Body Mass Index, body weight and the hematocrit level were significantly associated with hyperuricemia in both sexes.

Aged↗
PubMed1988

Rat metabolic adaptation to ammonia inhalation.

Rats exposed to 25 or 300 ppm NH3 vapor for 5-15 days 6 hr daily showed dose-dependent blood ammonia after 5 days. Brain and blood glutamine were also increased at the same time in rats exposed to 300 ppm. The blood ammonia concentration of the exposed rats resumed control levels at 10 and 15 days while hepatic citrulline synthesis increased above that of the controls. The animals exposed to 300 ppm NH3 showed initially a slight acidosis. As circulating ammonia decreased, brain and blood glutamine returned to the control range. Our findings support the idea that ureagenesis is aimed mainly at the removal of NH+4 with only secondary and small effects on the acid-base balance.

Absorption↗
PubMed1986

Dissolution of stainless steel welding fumes in the rat lung: an x ray microanalytical study.

The dissolution of stainless steel welding fumes produced by manual metal arc (MMA) and metal inert gas (MIG) techniques was studied by transmission electron microscopy and quantitative x ray microanalysis in the lungs of rats after inhalation exposure. Rats exposed to stainless steel fumes generated by MMA were found to have two particle populations of different behaviour in their lung tissue. The particles of the principal population (size 100-250 nm) dissolved in both alveolar macrophages and type 1 epithelial cells in about two months. Fast and slowly dissolving components of chromium, manganese, and iron were detected within these particles; they obviously represent different chemical compounds. The particles of the minor population (size 5-100 nm) showed no signs of dissolution during three months follow up. Rats exposed to stainless steel fumes generated by MIG had only one particle population in their lung tissue; they were similar to those of the minor population in the MMA/SS fumes and no solubility could be detected within three months.

Animals↗
PubMed1986

Hard metal lung disease: a clinical, histological, ultrastructural and X-ray microanalytical study.

Four employees occupied in hard metal grinding work at the same machine shop developed interstitial lung disease after 2-7 years of working. Open lung biopsies from two of them showed giant cell interstitial pneumonia with bronchiolitis. The multinucleate giant cells were shown by electron microscopy to include both pneumocytes and macrophages. The giant pneumocytes were severely damaged, the endoplasmic reticulum being swollen and the few lamellar bodies being small, and some mitoses were visible in the pneumocytes. No mitoses were found in the giant macrophages. Pulmonary dust particles were studied in situ by scanning transmission electron microscopy and energy-dispersive spectrometry. Cobalt was no longer found in most of the pulmonary hard metal particles, but it was regularly detected in grinding dust particles in air samples studied by scanning electron microscopy and energy-dispersive spectrometry.

Adult↗
PubMed1985

Health status and social conditions of the elderly in remote districts. Results of a screening programme.

In 1978 a cohort of 1040 individuals aged 65 years or over was screened by public health nurses in Kuusamo. The screening produced basic data about health status and social conditions for an intervention of active medical care of the elderly by means of a mobile unit in rural districts. The response rate of the screening was 90%. 72% of the men and 35% of the women lived with their spouse; 6% of the men and 20% of the women lived alone. Poor health was assessed least commonly (36%) by those living alone, and most commonly by women living with their spouse (51%), even though 87% of them were under 75 years old. A visit to a physician during the past 12 months was more common among younger subjects. 15% of the men and 18% of the women had slightly restricted mobility. Men living alone had better mobility than women living alone.

Activities of Daily Living↗
PubMed1984

Quantitative x ray microanalysis of pulmonary mineral particles in a patient with pneumoconiosis and two primary lung tumours.

The right upper lung lobe of a 74 year old man was resected for a central tumour. Two primary cancers were found; a central small cell carcinoma and a peripheral squamous cell carcinoma. In addition, the peripheral lung tissue showed generalised peribronchiolar fibrosis extending from the non-respiratory bronchioles to the level of the alveolar ducts. Abundant asbestos bodies and large amounts of black dust were seen around the bronchioles. Pulmonary mineral particles were studied by quantitative energy dispersive x ray microanalysis (EDS) using scanning transmission electron microscopy (STEM). The x ray spectra for mineral particles were measured in thin sections, and the characteristic peak intensities of the elements were converted to weight fractions (in oxides). The results enabled the minerals present to be identified and their presence confirmed by calculating the mineral formula. These originated from nine natural minerals, anthophyllite and chrysotile asbestos, talc, and quartz, feldspars, and muscovite, which are components of sand, and also from two artificial mullites used in fire clay. The exposure history of the patient explained the most likely origins of the minerals detected. The patient had been a mason for 23 years, repairing and demolishing stoves and fireplaces and using asbestos for insulation work.

Aged↗
PubMed1984

Lysosomal gold accumulations in pulmonary macrophages.

Although soluble gold has been widely used in the treatment of rheumatoid arthritis, little is known about the distribution of gold deposits in extra-articular tissues. In the synovial lining cells and articular cartilage, the morphology of lysosomes containing gold, the aurosomes, is well documented. Because gold may cause pulmonary injury, the morphology and distribution of gold deposits in pulmonary tissue should be recognized. We found morphologically typical aurosomes with electron-dense membranes and granules, giving the spectrum of gold in electron microprobe analysis, in the interstitial and alveolar macrophages in the open lung biopsies of 3 patients who had received gold treatment but not in 12 patients who had not received gold treatment. In contrast to previous studies, aurosomes were not found in the endothelial cells.

Arthritis, Rheumatoid↗
PubMed1984

Rheumatoid pneumoconiosis in a dolomite worker: a light and electron microscopic, and X-ray microanalytical study.

A 46-year-old woman suffering from rheumatoid arthritis developed numerous round opacities at the apex of the right lung 11 years after an exposure to dolomite . Resected lung showed discrete nodules, 0.8-2 cm in diameter, with central necrosis surrounded by palisading fibroblasts and a prominent inflammatory zone. A large number of birefringent dust particles were seen in the necrotic centres and around the nodules. By electron microscopy the particles were dense, mostly elongated and lamellar, varying from 0.005 to 3 microns in width, and from 0.1 to 6.5 microns in length. Energy dispersive x-ray microanalysis of the dust particles gave elemental spectra with high spikes of silicon, aluminium and potassium, and minimal magnesium, calcium, iron and titanium. According to chemical analysis, the original dolomite consisted almost entirely of magnesium and calcium carbonates and only of traces of silicon, aluminium and potassium. Apparently the human organism can better eliminate calcium and magnesium carbonates than silicon, aluminium and potassium.

Calcium Carbonate↗
PubMedDate not supplied

Point-mutational MspI and Ile-Val polymorphisms closely linked in the CYP1A1 gene: lack of association with susceptibility to lung cancer in a Finnish study population.

In this study of 87 lung cancer patients, 23 patients with lung disease other than cancer, and 121 healthy controls, no association was found between the MspI restriction fragment length polymorphism (RFLP) of the CYP1A1 gene and lung cancer risk. In the lung cancer population, histological type, smoking, and occupational histories were also examined with respect to increased lung cancer risk. No association was found between the MspI RFLP in the CYP1A1 gene and any of these variables. This is in contrast to the results of an earlier report describing an association between the rare genotype m2m2 and susceptibility to lung cancer in a Japanese population; but another study in Norway found no such association. It is evident that, in the Nordic population, MspI polymorphism in the CYP1A1 gene does not indicate individual susceptibility to lung cancer. We also studied a new point mutation which has recently been closely linked to the MspI restriction site polymorphism in a Japanese study population. This mutation results in an isoleucine-valine amino acid replacement in the heme binding region of human CYP1A1. We obtained a similar linkage in our study, so the discrepancy between the Japanese and the Nordic MspI RFLP findings cannot be based on a different degree of linkage between these two point mutations.

Alanine↗