Consensus statement on dementia of Alzheimer type in the severe stage.
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Biomedical subjects
Publications and source records attributed to S Andrieu.
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In order to establish that a drug has an impact on disease progression, a clinical trial must study both the symptomatic and the disease modifying effect of the drug. Disease modifying trials raise some methodological issues with regard to the choice of the design (parallel arm versus two- period design), of the outcome (clinical versus surrogate) and of the statistical analysis (management of missing data).
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The taxonomical value of the specific distinction of C. albicans and C. stellatoidea was in mind, in the mycological study of: one homogenous group of 292 isolates of C. albicans and an other of 11 C. stellatoidae, of collection in majority. The growth in a liquid medium, the production: of chlamydospores, mycelium, pseudomycelium, germ-tubes, the fermentation and assimilation of carbohydrates, the tetrazolium-test, the actidione resistance and the maximal temperature for growth were the morpho-physiological characteristics studied. Were also reported some variations observed on two C. stellatoidea from which the type-strain of that species, cultured in two different laboratories.
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