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Biomedical subjects

S Andrieu

Publications and source records attributed to S Andrieu.

At least 55 records · Page 3Linked to original sources
PubMed1998

[Torsional abnormalities and length discrepancies after intramedullary nailing for femoral and tibial diaphyseal fracture. Computerized tomography evaluation of 189 fractures].

PURPOSE OF THE STUDY: We retrospectively determined by computed tomography torsionnal abnormalities and length discrepancies after diaphyseal tibial and femoral fractures treated by intramedullary nailing. MATERIAL: Eighty femoral fractures and 89 tibial fractures were evaluated after healing. All these patients were treated by Grosse-Kempf intramedullary locked nail. AO classification was used: there were 16 type A, 32 type B and 32 type C, femoral fractures. Tibial fractures were 48 type A, 29 type B, and 12 type C. Reaming was systematic, 90 per cent of the nailing were static. METHODS: We measured comparatively length and torsion of tibias and femurs after bone healing and tried to find statistical correlation between clinical, epidemiological, anatomical factors and CT measurements. RESULTS: For the femur the mean difference in torsion was 9.9 degrees (max. -21 degrees min. +45 degrees) 52.5 per cent had the same measurements in intact and fractured side. For tibias the mean torsionnal value was 6.84 degrees. Seventy three per cent of patients had the same torsion in intact and fractured side. The mean femoral length discrepancy was 6.3 mm (max. -25 mm min. +19 mm) and 4.1 mm (max. -19, min. 20 mm) for the tibia. There were no statistical correlation. DISCUSSION: Even though there is no clinical sign after torsionnal abnormalities in our patients, hip, knee or ankle arthrosis is possible after nailed shaft fracture. A long term follow-up is necessary. A prospective study will be necessary in order to assess the exact frequency of these malalignements.

Adolescent↗
PubMed1997

[Predictive factors of institutionalization of dependent elderly persons].

BACKGROUND: This study analyses the factors related to the institutionalization of dependent patients living in the community and receiving informal care from relatives. METHODS: The study is based on a 3-year follow-up of a sample of 205 pairs (carereceiver-caregiver). Eligible care receivers were aged 65 years and over, living at home, and physically or mentally dependent. Caregivers were interviewed at inclusion and three years later in order to know whether the elderly was institutionalized or still living at home. RESULTS: Cox proportional hazards analysis indicated that significant predictors of subsequent institutionalization were intention to institutionalize (p = 0.001), caregiver type (p = 0.015), caregiver's subjective perception of patient behavior problems (p = 0.009), and, at a lesser extent, to live in a urban environment (p = 0.051). The functional status and the carereceiver's age were not predictive of institutionalization. CONCLUSION: This study emphasizes the importance of subjective factors and characteristics of the primary caregiver in predicting institutionalization of elderly dependent persons.

Age Factors↗
PubMed1982

[Leptosphaeria (?) senegalensis, Segrétain, Baylet, Darasse et Camain. Perithecia and asci. II. Asci and ascospores].

The ascal wall of Leptosphaeria senegalensis typically belongs to the bitunicate type; in its fin al state it comprises an exoascus separated from the endoascus by a clear space. The three-layered endoascus is formed of fibrillae whose most internal are accordion-like folded. The ascospores have a complex wall; from the interior to the exterior it comprises: an endospore, an irregularity thickened epispore, a perispore, and an ectospore thickened in a cap at the posterior end of the spore. The comparison of ascospores of two "real" Leptosphaeria (L. acuta et L. maculans) with those of L. senegalensis shows that the latter species must no longer be included in the genus Leptosphaeria.

Ascomycota↗
PubMed1981

[Leptosphaeria (?) senegalensis Segretain, Baylet, Darasse et Camain. Perithecia and asci. I. Perithecial ontogeny and structure (author's transl)].

Perithecia of L, snegalensis develop from stromato-glomerular type primordia. One or several female cells (=ascogones), each of them topped by a trichogyne, appear in the carpocentral mass; each ascogone directly produces dicaryotic cells without any intervening pro-sporophytic vesicle. The development of the sterile elements is typical of an ascolocular Pryremomycete with a Pleospora type carpocentrum: formation of a perilocular layer composed of a non persistent subhymenial meniscus and a bell-shaped suprahymenial meniscus generating pseudo-paraphyses but no periphyses.

Ascomycota↗
PubMed1977

[Photoinhibition of chlamydosporulation of Candida albicans].

Candida albicans produced chlamydospores after 24 h in the dark at 27 degrees C, but the process was inhibited under adequate irradiation of light. The in vivo absorption spectra showed a main peak at 414 nm, and less important peaks at 430, 446, 477, 519, 549 and 560 nm. No bands were detected beyond 600 nm. A total inhibition of chlamydosporulation occurred at 414 nm (monochromatic light) for an initial energy of 2,000 ergs cm-2 s-1. A 4,000 ergs cm-2 s-1 irradiation energy was necessary to observe a marked inhibition at 460, 500 and 530 nm (les chlamydospores and/or immaturity); this energy must be raised to 300,000 ergs cm-2 s-1 to observe a similar effect at 575 and 630 nm. Biological activity spectra were in full concordance with absorption spectra at 414 nm; no interpretation of absorption band at 460 nm is given, but total or partial inhibition could be explained by modulation of protoporphyrin activity.

Candida albicans↗
PubMed1977

Identification and purification of the specific antigen of Paracoccidioides brasiliensis responsible for immunoelectrophoretic band E.

A new purified antigen (E2) of Paracoccidioides brasiliensis mycelial growth phase was isolated by immunoadsorption from a crude metabolic soluble extract of the fungus. The antiserum prepared in a rabbit by inoculation of E2 antigen developed only one immunodiffusion line with the crude metabolic extract. Findings on immunological analysis showed that E2 antigen is the antigenic component of immunoelectrophoretic band E. The isolated antigens did not possess detectable alkaline phosphatase activity. It reacted in immunodiffusion tests with all the sera (14/14) from P. brasiliensis infected patients containing precipitating antibodies.

Antigens, Fungal↗
PubMed1976

Sulphitolysis in keratinolysi. Biochemical proof.

The presence of S-sulphocysteine in filtrates of the dermatophyte Keratinomyces ajelloi growing on human hair in a culture medium buffered by pH 7-4 by phosphates was demonstrated by means of ion exchange chromatography techniques. S-sulphocysteine being destroyed during acidic hydrolysis was identified after enzymic hyrolysis of dialyzed and lyophilized filtrates. This result indicates that sulphitolysis occurs during kerationlysis performed by K. ajelloi. As thiosulphuric esters were shown present in hair perforations made by Microsporum gypseum, we think sulphitolysis is a common mechanism developed by dermatophytes to attack keratin.

Culture Media↗
PubMed1976

Isolation of a specific antigen with alkaline phosphatase activity from soluble extracts of Paracoccidioides brasiliensis.

A specific antigen of Paracoccidioides brasiliensis was isolated from a metabolic extract of the fungus. The extraction was made by specific adsorption to and subsequent elution from a column containing a cross linked polymer to which the antibodies of a monospecific rabbit serum had been covalently attached. The purity of the final product was demonstrated by immunodiffusion analysis of the eluate using immune serum produced in a sensitized rabbit. The purified antigen was shown to have cationic electrophoretic mobility and alkaline phosphatase activity.

Alkaline Phosphatase↗
PubMed1976

[Limits of pure analgesic anesthesia].

Before dealing with this subject, the author believes that it is useful to give a definition of this technique and justify it. He then recalls the results which he obtained with various analgesic drugs, few products permit this technique, either because of too low analgesic power, or because of the appearance in high dosage, of troublesome or dangerous side-effects. At present, in this type of anesthetic, one may use either morphine or fentanyl or fentathienyl. Analgesic anesthesia with morphine. This technique presents advantages and disadvantages. The author has no personal experience of high doses of morphine and can only report that of other authors who have studied this problem. Anesthesia analgesia with fentanyl and fentathienyl. The author believes that this technique presents advantages over the previous technique, he has personally studied the clinical pharmacology of high doses of fentanyl and he believes that this drug used by the intravenous route, at a dose of 0.05 mg/kg associated with a curare derivative, possesses favourable cardiovascular and respiratory metabolic effects during the surgical operation, but one must recognize that +/-20 p. 100 of cases, fentanyl associated only with curare is not sufficient to give a stable anesthetic. At present, the author has replaced, in his technique, fentanyl by fentathienyl which is a morphine derivative 6 to 7 times more powerful. He found with this drug most of the properties of high doses of fentanyl but the analgesia obtained is deeper, one does not find more than 20 p. 100 of resistant cases. However, the author noted the fairly frequent appearance of tachycardia for which there was no valid explanation. In conclusion. The author believes that in the reproaches which are made to analgesic anesthesia, some are justified, others are less so. It requires prolonged post-operative supervision, but the latter would be advisable for any other type of anesthesia. It dose not always permit one, in its pure form, to obtain stable anesthesia, but this is less and less true with the appearance of more and more powerful derivatives. The use of analgesic anesthesia as a routine technique is only possible in the form of sequential analgesic anesthesia, a technique which uses an antimorphine drug to awaken the patient. In this field, various new products are presented are discussed.

Analgesia↗