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Biomedical subjects

S Andreassen

Publications and source records attributed to S Andreassen.

58 records · Page 4Linked to original sources

Medical expert systems based on causal probabilistic networks.

Causal probabilistic networks (CPNs) offer new methods by which you can build medical expert systems that can handle all types of medical reasoning within a uniform conceptual framework. Based on the experience from a commercially available system and a couple of large prototype systems, it appears that CPNs are now an attractive alternative to other methods. A CPN is an intensional model of a domain, and it is therefore conceptually much closer to qualitative reasoning systems and to simulation systems than to rule-based or logic-based systems. Recent progress in Bayesian inference in networks has yielded computationally efficient methods. The inference method used follows the fundamental axioms of probability theory, and gives a sound framework for causal and diagnostic (deductive and abductive) reasoning under uncertainty. Experience with the prototypes indicates that it may be possible to use decision theory as a rational approach to test planning and therapy planning. The way in which knowledge is acquired and represented in CPNs makes it easy to express 'deep knowledge' for example in the form of physiological models, and the facilities for learning make it possible to make a smooth transition from expert opinion to statistics based on empirical data.

Artificial Intelligence↗

The development of a multicenter database for reference values in clinical neurophysiology--principles and examples.

This paper describes the work undertaken to establish principles for the development of multicenter databases for reference values in clinical neurophysiology. The study was initiated because of interest of the involved laboratories in knowledge-based systems in electromyographic diagnosis, for which it was necessary to formalize the key concepts in the diagnostic process: diseases, pathophysiology and test results. The paper deals specifically with the structuring of results of motor and sensory nerve conduction studies.

Action Potentials↗

The EMG diagnosis--an interpretation based on partial information.

There is a large difference between the prevalence of a given disease in the general population and in the population seen in the EMG lab. It can be argued that both prevalences are the correct choice as prior probabilities for the diseases. This paradox is resolved by recognizing that the EMG diagnosis is only based on the information provided by the EMG examination and thus only represents a partial view of the patient. We propose a solution summarizing the set of findings, signs and symptoms, lab results etc., that led to the referral of the patient for an EMG examination. This information is described by stochastic variables called FIDL factors (Found In Doctor's Lab). The approach is tested on the EMG expert system MUNIN with 30 previously evaluated cases. The results show that this solution improves the specificity of the diagnosis, without affecting the sensitivity.

Decision Support Systems, Clinical↗