After an acute HbsAg-positive transfusion hepatitis the patient--a 40 years old women--remained seropositive. Later a chronic aggressive hepatitis have developed, which could be evidenced by histological findings. On the electron microphage in the nucleus of liver cells ring-shaped particules 20--25 nm in diameter were revealed. They consisted of granula 2--3 nm in diameter. These particules are considered to represent so called virus-nuclei (core of the virus B of hepatitis) and to play a pathogenic role. These particules are commonly present and easily found. The great number of them--according to author's opinion--can be explained by the effect of immunosuppressive therapy.

Cell Nucleus↗

PubMedDate not supplied

[The diagnosis of neonatal bacterial infections with mother-fetus transmission recorded in 1983-1987 in the Newborn Ward of the Baia Mare County Maternity Hospital].

The diagnosis of infectious bacterial neonatal syndrome (IBNS) was based on 3 arguments: --the suggestive anamnestic investigation of the mother; --clinical signs revealing the infection in the new-born child; --paraclinical data. The evoking anamnestic data during pregnancy and parturition are highly important. Of them, the most frequently met were: premature rupture of the membranes, modified amniotic liquid; with or without premature rupture of the membranes, urinary infections declared but not sufficiently treated, fever and pseudoinfluenza syndrome in the last term of the pregnancy etc. The clinical signs revealing the infection in the new-born are: disturbance in the behaviour and the proper clinical signs. Of the clinical data the authors followed the evolution of the hematologic data, the inflammatory test--serologic and bacteriologic (the greatest importance was given to the blood cultures and seeding in CSF). Therefore, IBNS transmitted through the mother-fetal route can be suspected only in the presence of conclusive anamnestic data. The clinical aspects, sometimes minor, corroborating the clinical evolution and the paraclinical data are of the greatest importance for the physician's decision. The clinical diagnosis based on serious clinico-anamnestic arguments should not be ignored by negative bacteriologic tests.

Adult↗