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Biomedical subjects

S Allen

Publications and source records attributed to S Allen.

303 records · Page 17Linked to original sources
PubMedDate not supplied

Entry: a new approach.

Despite all of the protections promised through grandfathering and pathways to educational mobility, the entry movement tends to be perceived by many to be "demoting" the lives and livelihoods of hundreds of thousands of RNs who do not possess the education to meet the proposed standard. Here is a proposal for a way out of the quagmire.

American Nurses' Association↗
PubMedDate not supplied

Pharmacokinetics of lopamidol after intrathecal administration in humans.

The kinetics of iopamidol, a new nonionic radiocontrast agent, were evaluated in 10 patients undergoing lumbar myelography. The doses of iopamidol administered intrathecally were 11 and 15 ml of a 200-mg iodine per ml solution in one and nine patients, respectively. Radiographs were made within 30 to 40 min and CTs were taken at about 1, 6, and 23 hr after iopamidol administration. The diagnostic quality and usefulness of the conventional and CT myelograms were considered excellent. In the lumbosacral subarachnoid space, the densitometry CT readings were maximal at 1 hr, whereas in the cervical subarachnoid space, peak CT values were reached at 6 hr. Plasma and urine samples were taken at frequent intervals up to 48 hr after the contrast agent was administered. Peak plasma levels of iopamidol were observed at 2.9 hr and were no longer detectable at 48 hr. The 48-hr urinary recovery for all patients averaged 66 +/- 8% of the dose. In all but one patient, iopamidol was cleared almost completely from the CSF within 24 hr. Side effects after iopamidol administration were transient and minor, and were not related to the CT readings or its systemic clearance.

Adult↗
PubMedDate not supplied

Safety of contrast media in cerebral angiography: iopamidol vs. methylglucamine iothalamate.

A randomized double-blind study was performed in 27 patients to compare the clinical safety, incidence of pain and warmth, and film quality produced by iopamidol and Conray-60 in selective cerebral angiography. No complications or adverse reactions occurred in either group. Iopamidol was significantly less painful than was methylglucamine iothalamate for common carotid artery injections and caused significantly less heat in both common carotid and internal carotid artery injections. Film quality and diagnostic accuracy were excellent in both groups. These results, when viewed in conjunction with laboratory data demonstrating the decreased neurotoxicity of nonionic contrast agents, suggest that iopamidol is an important advance in the development of angiographic contrast media.

Adult↗
PubMedDate not supplied

Clinical trial of iopamidol for lumbosacral myelography.

The results of the initial North American trial of the nonionic, water-soluble contrast medium iopamidol for lumbosacral myelography are reported. The iopamidol was easily visualized by fluoroscopy during introduction, and the radiographic quality of all 12 conventional myelographic examinations was excellent. The diagnoses were herniated nucleus pulposus (seven), traumatic dislocation (one), metastasis (one), and normal (three). One patient had a repeat myelogram with a different hydrosoluble contrast medium 2 months after his iopamidol examination and surgery and showed no radiographic evidence of arachnoiditis. The adverse reactions were all mild and transient: headache (four cases), nausea (two), and leg pain (one). There were no diaphoresis, fever, seizures, hallucinations, agitation, or vital sign changes. Electrocardiography, hematology, and blood chemistries were all normal. In two patients, electroencephalogram changes, three to four bursts of diffuse intermittent rhythmic delta activity with no spiking, were present at 6 hr with return to normal at 24 hr.

Clinical Trials as Topic↗
PubMedDate not supplied

Transvenous implantation of cardioverter defibrillators in the Electrophysiology Laboratory at CAMC.

Since 1989, 78 patients have had Implantable Cardioverter Defibrillator (ICD) systems implanted in the Electrophysiology Laboratory (EPS) at the Charleston Area Medical Center. Between June 1993 and December 1994, 28 patients (21 males, 7 females) had new transvenous ICD systems successfully implanted in the Electrophysiology Laboratory. Coronary artery disease was present in 22 patients (76%). The mean left ventricular ejection fraction measured 28 percent (range 19%-45%), and the mean follow-up was 159 +/- 112 days (5.3 months). Twelve patients (43%) experienced shock, with an average of three per patient. The implantation of transvenous ICD systems in an electrophysiology laboratory is feasible, efficacious, safe, and associated with rapid patient recovery. With advances in technology, the procedure is becoming more comparable to a pacemaker implantation.

Cardiomyopathy, Dilated↗
PubMedDate not supplied

Mix and match.

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Female↗
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Immunoaffinity column coupled with liquid chromatography for determination of fumonisin B1 in canned and frozen sweet corn.

A modified liquid chromatographic (LC) method for determining fumonisin B1 (FB1) in corn was applied to canned and frozen sweet corn. The corn is extracted with methanol-water (8 + 2), and the extract is filtered. The filtrate is diluted with water and passed through an immunoaffinity column. After the column is washed with water, FB1 is eluted with methanol-water (8 + 2). The eluate is evaporated to dryness by using a vacuum concentrator, and the residue is dissolved in acetonitrile-water (1 + 1). FB1 is derivatized with o-phthaldialdehyde. The derivative is separated on a reversed-phase C18 LC column using acetonitrile-water-acetic acid (50 + 50 + 1) and quantitated with a fluorescence detector. Recoveries of FB1 from canned and frozen corn spiked over the range of 50-200 ng/g were 76-88%. The limit of determination was about 25 ng/g, and the limit of detection was about 4 ng/g. The method was applied to 97 commercial canned and frozen sweet corn samples collected from different areas of the United States. Sixty samples contained no FB1. Low levels (trace-82 ng FB1/g corn) were found in 35 samples; 235 ng FB1/g was found in 1 canned corn sample, and 350 ng FB1/g was found in 1 frozen corn sample.

Chromatography, Affinity↗
PubMedDate not supplied

A large transmural thoracic lipoma easily mistaken for pulmonary malignancy.

Lipomas in the thorax are very rare. Most such lesions are asymptomatic and discovered by accident on a chest radiograph. However, radiographic features are non-specific and can mimic malignancy. We describe the case of an 82-year-old woman whose history and chest radiograph suggest a malignant lung tumour. A computed tomography scan of the chest eventually determined the fatty nature of her chest lesion.

Aged↗
PubMedDate not supplied

Smoking cessation programme for self-motivated patients.

Mr Mitchell felt that each weekly session had provided him with the impetus to continue for another week. He showed great determination to succeed and followed the recommended method, adapted to suit his own lifestyle. I felt professional satisfaction knowing that I had played a significant part in his transition from smoker to non-smoker. The method I used with Mr Mitchell was effective. However, it is only one of many methods available to smokers and health professionals. At present 22 patients have booked in for stop-smoking sessions. Six have completed the six sessions and of those, three remain non-smokers six months later. All three were self-referred and therefore highly motivated. Even one success is one more towards achieving the Health of the Nation target and is well worth the time and effort involved.

Adult↗