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S Albert

Publications and source records attributed to S Albert.

At least 91 records · Page 5Linked to original sources
PubMed1983

Occupation and cancer of the lower urinary tract in Detroit.

The relationship between occupation and cancer of the lower urinary tract in Detroit was examined by means of a population-based case-control study conducted as part of the National Bladder Cancer Study. Three hundred three white male patients with transitional or squamous cell carcinoma of the lower urinary tract and 296 white male controls selected from the general population of the study area were interviewed to obtain lifetime occupational histories. Our findings suggested that truck drivers have a significant increased risk of lower urinary tract cancer [relative risk = 2.1; 95% confidence interval (Cl) = 1.4-4.4]. A significant trend in risk was apparent with increasing duration of employment as a truck driver (P = 0.004); the relative risk estimated for truck drivers employed at least 10 years was 5.5 (Cl = 1.8-17.3). Truck drivers with a history of operating vehicles with diesel engines experienced a significant elevated risk compared to non-truck drivers (relative risk = 11.9; Cl = 2.3-61.1), but whether the increased risk observed among truck drivers was attributable to diesel exposure could not be evaluated. Nonsignificant excess risks were also seen for tool and die makers as well as for workers in several other industries and occupations. Employment in the motor vehicle manufacturing industry was associated with no significant excess risk of lower urinary tract cancer (relative risk = 1.1; Cl = 0.8-1.5).

Adult↗
PubMed1982

Current surgical management of in situ cancer of the female breast.

Surgical procedures for breast cancer were compared in 468 cases with in-situ and 4,967 cases with invasive lesions. The cases were obtained from the Michigan Cancer Foundation Registry, a Surveillance, Epidemiology, and End Results (SEER) participant, and were incident-resident cases diagnosed from 1973-1978. For single, primary in situ or invasive cancer, the preferred mastectomy was modified radical. Partial and simple resections were used more often than radical procedures for non-infiltrating, especially lobular lesions. For cases with bilateral primates, with at least one in situ, the mastectomy of choice was the simple procedure for the in situ malignancy and modified radical for the invasive cancer. The change in preferred surgery for in situ lesions, from modified radical to simple mastectomy, was not due to any change in strategy for treatment of bilateral invasive disease, which remained modified radical resection.

Adult↗
PubMed1982

Race, age and cancer incidence: a test of double jeopardy.

One form of the double jeopardy hypothesis states that health declines more dramatically with age for blacks than it does for whites. This paper tests the hypothesis for black and white differences by age in cancer incidence rates. Age-specific incidence rates for 14 major cancer sites were compared in black and white, male and female populations in Detroit. Rates were based on 57,275 invasive cancer cases, diagnosed between 1973 and 1978, and drawn from the Michigan Cancer Foundation Registry, a member of the National Cancer Institute's Surveillance, Epidemiology, and End Results program. For men, differences between blacks and whites for most sites dissipate with age, reflecting a leveling trend. For women, there is no consistent trend for most sites. Double jeopardy is reflected in rates for cervical cancer. Public health programs should be targeted to elderly black women for cervical cancer screening and to middle-aged black men for multiphasic cancer prevention services.

Adult↗
PubMed1982

Breast parenchymal patterns: analysis of 332 incident breast carcinomas.

A detailed analysis of 332 incident breast carcinomas is presented. The study results indicate that there is validity to the breast parenchymal patterns as an indication of risk for developing breast cancer and that risk is independent of length of follow-up and age of patient. All cases were drawn from a referral-type practice at Hutzel Hospital, Detroit, MI. The cases were compared to controls for computation of relative risk up to and beyond a follow-up period of 48 months. They were also compared to a consecutive series of prevalent breast carcinomas seen at Hutzel Hospital during the 6 years 1975-1980. The extent of disease in the cases described in this report is somewhat more favorable than in a consecutive series of prevalent cancers operated on a Hutzel Hospital. Most breast cancers occur in the P2 breast, a smaller number in the DY, and only 12% in the combined N1P1 type. The conclusions of other investigators regarding parenchymal patterns as risk indicators are reviewed. Particular attention was paid to comparing the length of follow-up and age of patient. There was no diminution of proportions of cases in the P2/N1-P1 or DY/N1-P1 after a 48 month follow-up. There was a significant diminution in the proportion of cases falling into DY/N1-P1 after age 50, and less so in P2/N1-P1. Furthermore, relative risk was unaffected by time or age.

Adult↗
PubMed1980

Familial influences on breast parenchymal patterns.

Some studies accomplished thus far have indicated that mammographic patterns may serve as risk indices for breast cancer. The present investigation was undertaken to determine whether patterns are familial. Mammograms from 110 mothers and their daughters and 122 sister pairs and a like number of unrelated controls matched for patient age, reproductive history, and personal and family history of breast cancer and drawn from the files of the Radiology Department of Hutzel Hospital, Detroit, Michigan, were compared. A familial influence was indicated by the finding that pattern similarities were significantly stronger in test cases than in unrelated controls. This influence appeared to be manifested by premature age changes in daughters and younger sisters and consisted, primarily, of a decrease in DY and an increase in P2 patterns. The data suggest that performing mammography on first degree relatives of women with high risk P2 and DY patterns should be considered.

Adult↗
PubMed1980

Faking psychosis on the Rorschach: can expert judges detect malingering?

The susceptibility of the Rorschach to faking of psychological disturbance has been subject to few studies, all of which have significant methodological deficiences. Faking of psychosis was examined in this study by using Rorschach experts as judges to blindly evaluate both faked and actual psychotic protocols. The faked protocols came from role-informed and role-uninformed individuals who were asked to specifically malinger paranoid schizophrenia on the Rorschach. The results indicated that the expert judges were unable to detect the faked psychotic protocols regardless of whether the faker was or was not role-informed. However, significantly more role-informed faked protocols received psychotic designations than both the role-uninformed faked and actual psychotic protocols. Expert clinical judgments o- the Rorschach are apparently very susceptible to faking of serious disturbance.

Adolescent↗
PubMed1978

Noncancer deaths in cancer and noncancer lineages.

Starting with white probands who were potential milk donors in a program of human milk collection, a series of 2411 family health histories were obtained of the first degree relatives of the probands' parents. A lineage is defined as the parents and siblings of a parent of the proband as well as the parent. 2090 cancers were identified in the 31,939 people. Of the 21,712 persons without cancer in the parents' generation, age-specific death rates were significantly higher in those lineages with at least one cancer. This was true in infants, children and adults for both males and females (p less than 0.001). Cancer may be linked to other morbid conditions by a commonality of heredity, family environment, or perhaps both as necessary antecedents--neither sufficient by itself.

Adolescent↗
PubMed1977

Familial cancer in the general population.

In the course of collecting samples of human milk for the National Cancer Institute, family histories have been assembled since 1971. Ages, causes of death, reproductive histories, and the history and age of occurrence of cancer were obtained for all first degree relatives of the proband's parents. Two thousand and ninety cancers were identified in 31,945 persons. Cancers were confirmed by pathology reports, hospitals' and doctors' records, or death certificates. Of the family lineages, 65.9% had no cancers and 8.0% had two or more. For all cancers taken together, clustering was not significant but there was significantly more observed than expected cancers in lineages with cancer of breast, ovary, skin, corpus uteri, stomach, rectum, lung and bronchus, or colon. Little or no excess was observed in lineages with leukemia, lymphoma, and cancer of the cervix or prostate. The relative risk of breast cancer was increased 1.5 times for daughters and 3.8 times for sisters of women with the disease.

Breast Neoplasms↗
PubMed1976

Adjunct hospital emergency toxicology service. A model for a metropolitan area.

A feasibility demonstration with a gas chromatograph/mass spectrometer/computer system (GC/MS) was initiated to provide a 24-hour (seven days/week) adjunct emergency toxicology service to the hospitals in the tricounty area comprising Metropolitan Detroit. During June 1, 1974, to April 1, 1975, more than 85 different drugs and other agents were identified in the body fluids of approximately 1,000 victims of accidental or deliberate poisonings. At least one toxic substance was identified in 57% of the cases, and the presence of two or more drugs was established in one of five (19%) of the victims. This study indicates that a centrally located GC/MS/computer system can provide an effective adjunct emergency toxicology service for an entire metropolitan community and thereby provide guidelines for a prompt and rational therapy.

Accidents, Home↗
PubMed1973

DNA polymerase activities of human milk.

DNA polymerases have been partially purified from human milk. A DNA polymerase detected by phosphocellulose chromatography is similar to the enzymes of RNA tumor viruses in that a hybrid of polyriboadenylate and oligodeoxythymidylate is a better template than is DNA. However, this polymerase differed from that of the RNA tumor viruses in its chromatographic behavior. Three different methods of detecting "reverse transcriptase" activity failed to correlate with the donor's family history of cancer.

Breast Neoplasms↗