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Biomedical subjects

S Akaishi

Publications and source records attributed to S Akaishi.

25 records · Page 2Linked to original sources
PubMed1979

Physico-chemical properties and local toxic effects of injectables.

In Japan, many cases of muscle contracture as a sequela of injections have been reported. We studied the physico-chemical properties and muscle-damaging potential of many injectables which are commonly used in hospitals. Contrary to our expectations, the pH of the injectables was found to range widely from 1.4 to 12.8, and the osmotic ratio from 0.2 to 36. It was also found that their hemolytic potential was closely related to the severity of the muscle lesions in animal experiments and that there were many injectables with strong muscle-damaging potentials. Therefore, doctors should be informed of the physico-chemical properties and tissue-damaging potential of each injectable; pharmaceutical companies should exert all possible efforts to improve injectables; and doctors should keep the administration of intramuscular injections to a minimum and use them only in cases of actual need.

Animals↗
PubMedDate not supplied

Alpha-1-antitrypsin (PiM) subtypes in Japanese.

Using isoelectric focusing (IEF) in thin-layer polyacrylamide gel, the polymorphism of the serum alpha-1-antitrypsin (Pi system) was investigated in 335 healthy unrelated Japanese individuals living in Miyagi prefecture, the northern part of Japan. Six common and five rare variant phenotypes were identified in our population samples, and the estimated allele frequencies for the genes PiM1, PiM2 and PiM3 were 0.718, 0.238 and 0.044, respectively. Family studies (n = 46) showed an autosomal codominant inheritance, and no exclusion was found in 23 mother-child pairs.

Child↗
PubMedDate not supplied

Transferrin (Tf) polymorphism: an analysis by isoelectric focusing.

The polymorphism of the transferrin (Tf) system was studied in a total of 300 unrelated Japanese individuals from Miyagi prefecture, the northern part of Japan using isoelectric focusing in thin-layer polyacrylamide gel. In our population samples three common phenotypes and nine variants were observed. The calculated allele frequencies were TfC1 = 0.773, TfC2 = 0.212, TfDchi (Chinese) = 0.008, and the combined frequencies for the TfBvar (variants) = 0.007. Family data (n = 44) were in accordance with an autosomal codominant fashion of inheritance. The use of isoelectric focusing procedure among Japanese will raise the probability of excluding a man falsely accused of paternity to 15.8% as compared with 1.5% when the conventional electrophoretic methods are used.

Asian People↗