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Biomedical subjects

S Abe

Publications and source records attributed to S Abe.

At least 991 records · Page 55Linked to original sources
PubMed1985

[Ultrastructural studies of central-type early squamous cell carcinoma of the lung].

Characteristics of the nuclei in histopathologic preparations obtained from a patient with bronchial carcinoma and two patients with microinvasive bronchial carcinoma were studied by transmission electron microscopy. In carcinoma in situ, the nuclei showed slight or moderate irregularity in the nuclear outline. The number of perichromatin granules was usually one to 10 per nucleus section. Formation of fibrillar centers was not marked. In microinvasive carcinoma, the nuclei were more irregular in nuclear outline than in carcinoma in situ. The number of perichromatin granule was usually more than 11 per nucleus section. Formation of fibrillar centers was predominant.

Aged↗
PubMed1985

Compositional changes in brain lipids, especially cerebroside and gangliosides, of rats treated with methylmercury chloride.

Rats were orally given 4 mg of methylmercury chloride per kg per day up to 14 days, and killed at 4-day or arbitrary intervals. Parietal gray matter and cerebellum were taken for lipid analyses. The ganglioside content increased during the early stage before the manifestation of clinical symptoms. After the onset of clinical signs, the total lipid concentration was elevated, and especially the levels of phosphatidylethanolamine and cerebroside were increased. The ganglioside distribution patterns were also altered in the late stage, showing decreased proportion of GD1a and increased percentages of GD1b and GQ1b.

Animals↗
PubMed1985

[Nidus embolization of cerebral arteriovenous malformation fed mainly by a pericallosal artery prior to surgical excision. Case report].

Nidus embolization of large arteriovenous malformation (AVM) by silastic spheres is not rarely performed prior to surgical excision of AVM. This technique is highly indicated for the large AVM supplied by the middle and the posterior cerebral arteries since silastic spheres injected into either the internal carotid or the vertebral arteries usually enter the middle or the posterior cerebral arteries due to less sharp angle from the main arteries. The authors report a case whose AVM, fed mainly by the anterior cerebral artery, was successfully embolized with silastic spheres using balloon catheter technique. On December 1, 1983, a 27-year-old man was admitted to our department with chief complaint of headache and clonic convulsion of the left upper and lower limbs. Convulsion began in 1973 and severe headache suddenly appeared two months prior to admission. He was neurologically asymptomatic on admission. Right internal carotid angiogram taken on admission showed a presence of large arteriovenous malformation in the medial portion of the right fronto-parietal lobe and corpus callosum fed mainly by the right pericallosal artery. Nidus embolization with silastic spheres was planned to make surgical removal easier. To prevent stray of silastic spheres into the right middle cerebral artery, balloon, introduced into the M1, was inflated for a few minutes, during which time, injection of 40 silastic spheres of 1.5 and 2.0 mm in diameter was performed via the right internal carotid artery. The nidus was significantly reduced and total removal of the nidus was successfully done 28 days following the embolization.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMed1984

SCE induction by indirect mutagens/carcinogens in metabolically active cultured mammalian cell lines.

Sister chromatid exchange (SCE) analysis in a total of 20 cultured mammalian cell lines of various types exposed to a variety of indirect mutagens/carcinogens suggested that, among these, several human and rat tumor cell lines are intrinsically capable of metabolizing a wide range of mutagens/carcinogens into genotoxic forms to induce SCEs. These cells may therefore serve as simple in vitro SCE test systems for screening of activation-dependent genotoxins without the use of an exogenous activating system. In addition, a comparison of the relevant metabolizing enzyme activity and inducibility of SCEs by mutagens/carcinogens in such cell systems appears to provide clues about the metabolic pathways related to SCE induction. Based on our own data and those in the literature, practical and theoretical advantages of the use of a direct-activating SCE test system in genetic toxicology are discussed.

Animals↗
PubMed1984

Electromyography of the external urethral sphincter in patients with prostatic hyperplasia.

We analyzed quantitatively the action potential of external urethral sphincter muscles by electromyography in 9 patients with benign prostatic hyperplasia and in 13 patients without micturition disturbances. In patients with benign prostatic hyperplasia the motor unit potentials had a mean amplitude of 290 plus or minus 40 microV., duration 5.0 plus or minus 0.1 msec. and phases 3.9 plus or minus 0.1. The control group values were 310 plus or minus 20 microV., 5.5 plus or minus 0.1 msec. and 3.8 plus or minus 0.1, respectively. There was a significant difference in duration, which was probably due to the difference in age of the 2 groups. An inverse relationship between age and duration was proved in the patients examined.

Action Potentials↗
PubMed1984

Isolation of Rickettsia tsutsugamushi antigenically different from Kato, Karp, and Gilliam strains from patients.

Rickettsia tsutsugamushi strains from three recent patients of Tsutsugamushi disease in Niigata Prefecture were isolated primarily in mice and then in L cell cultures. By this procedure, low virulent strains to mice, as well as high virulent ones, could be isolated and cultivated serially in L cell cultures, suggesting the usefulness of L cells for isolation of this species of rickettsia. Each newly isolated strain was identified as a member of R. tsutsugamushi from the results of cross immunological tests and morphological observation. On the other hand, it was recognized that one of these rickettsiae showed immunological properties distinguishable from the prototype strains of Kato, Karp, and Gilliam by the cross complement fixation test, and also had low virulence in mice.

Animals↗
PubMed1984

Gallium-67 scintigraphy, bronchoalveolar lavage, and pathologic changes in patients with pulmonary sarcoidosis.

The intensity of gallium-67 scintiscans, lymphocyte counts in bronchoalveolar lavage fluid, and pathologic changes were studied in 26 patients with untreated pulmonary sarcoidosis. Noncaseating granulomas were recognized with significantly greater frequency in stage 2 (80 percent; 8/10 cases) than in stage 1 (43 percent; 6/14 cases). Alveolitis showed little relation to the roentgenographic stage. There was a strong correlation between the intensity of gallium uptake in pulmonary parenchyma and the detection rate of granuloma; however, the detection rate of alveolitis was not statistically different from the intensity of gallium uptake. A highly significant correlation was revealed between the lymphocyte counts in bronchoalveolar lavage fluid and the intensity of alveolitis. These observations suggest that the gallium uptake reflects mainly the presence of granuloma, and the lymphocyte count in bronchoalveolar lavage fluid reflects the intensity of alveolitis in patients with pulmonary sarcoidosis.

Adolescent↗
PubMed1984

Modelling of cosmic-ray muon exposure in building's interior.

Physical parameters on the exposure indoors from cosmic ray muons were determined in order to undertake computer simulations. The hitherto known information was compiled, and the unknowns were newly calculated. Assumptions and approximations required in making a practical model were also described. The stopping power and the range of muons in a normal concrete as well as the air were calculated for the energy up to hundreds GeV. The consistency of those results with ready-made tables was found satisfactory although the comparisons were available only in the low energy tail. The scattering effect of cosmic ray muons in building's interior was examined numerically through very simple model calculations. It was revealed that the overall scattering effect would be ignored unless very small variations are wanted. The iron fraction in a reinforced concrete as well as the density of the concrete was also shown to be an ineffective factor.

Computers↗
PubMed1984

Calculation on cosmic-ray muon exposure rate in non-walled concrete buildings.

Computer simulations on the exposure indoors from cosmic ray muons were practiced in the framework of non-scattering and non-cascade assumptions. The model buildings were two-dimensional, rectangular, and were made of a normal concrete. A stratified structure was assumed in each building, where no mezzanine was considered. Walls were not taken into account yet. The distributions of the exposure rates in 26-story buildings were illustrated in contour maps for various sets of parameters. All of them gave basically archlike patterns. Analyses of the results showed that the exposure rate is affected most largely by the floor board thickness. The ceiling height would be an insignificant factor for short buildings. The min/max ratio of the muon exposure rate in a moderate size building was estimated to be more than 0.7.

Computers↗