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S A Zhizhina

Publications and source records attributed to S A Zhizhina.

17 recordsLinked to original sources
PubMed1991

[Study of the status of energy metabolism in thyrotoxicosis by the insulin test].

The insulin test was carried out in 68 healthy subjects and 20 patients with moderate thyrotoxicosis at the stage of compensation. Blood levels of pyruvate and lactate, plasma and erythrocytic glucose, urinary catecholamines and gas exchange were measured before, 30 and 120 min after intravenous administration of insulin (0.15 U/kg). All the measurements evidenced hypermetabolism: oxygen consumption, carbonic acid production, pulmonary ventilation were enhanced; lactate-pyruvate index and urine catecholamines were lower versus those of healthy subjects. Correlation analysis demonstrated disturbed regulation of hyperventilation by the sympathetic-adrenal system in thyrotoxicosis.

Adult↗
PubMed1990

[Hemodynamics and its control in patients with thyrotoxicosis and in healthy persons according to the data of anapriline and graded exercise tests].

The study was undertaken to examine effects of anapriline on bicycle ergometric and echocardiographic parameters and catecholamine excretion in 17 patients with thyrotoxicosis and 21 healthy subjects. A single dose of anapriline contributed to transition of hyperkinetic central hemodynamics to eukinetic one and a more saving regimen of heart performance at rest and submaximal exercise levels in the healthy subjects. In contrast, the patients maintained hyperkinetic hemodynamics and had a high energy demand during exercise and showed a reduction in left ventricular systolic and diastolic function and a significant decrease in catecholamine excretion. Disintegration of regulatory mechanisms in thyrotoxicosis was found to be due to the function interrelationship between thyroid hormones and catecholamines.

Adult↗
PubMed1989

[Characteristics of hormonal regulation in patients with ischemic heart disease after the insulin test combined with physical load].

Nine normal subjects and 6 coronary patients (aged 26 to 53 years) who had survived myocardial infarction more than 3 years before and showed no clinical signs of heart failure, obesity, hypertension and diabetes mellitus, while having normal glucose tolerance test values, were exposed to the insulin test in combination with physical stress in the presence of clinically manifest hypoglycemia. Plasma and erythrocyte glucose and immunoreactive insulin, and urinary excretion of catecholamines were measured. Coronary patients showed considerably increased erythrocyte immunoreactive insulin levels, recorded immediately upon discontinuation of exercise, while their sympathoadrenal hormonal activation was less significant, as compared to normal subjects. The combination of the insulin test and exercise in coronary patients with normal glucose tolerance values helps to detect disturbances of regulatory mechanisms at the erythrocyte level and can be used as an adjuvant method for the assessment of latent carbohydrate metabolic disorders.

Adult↗
PubMed1988

[Hemodynamic mechanisms of the decrease in physical work capacity in hypothyroidism and thyrotoxicosis].

A study of 21 patients with hypothyroidism, 22 patients with thyrotoxicosis and 18 normal subjects, using echocardiography and bicycle ergometry, demonstrated different mechanisms of reduced working capacity, associated with those conditions. The decrease in chronotropic and inotropic heart reserve, associated with hypothyroidism, is shown to be rooted in slowed-down relaxation of left ventricular posterior wall in the presence of diastolic arterial hypertension, while limited working capacity, associated with thyrotoxicosis, is rooted in resting myocardial hyperfunction due to hyperkinetic circulation.

Adult↗
PubMed1987

[Tolerance of the cardiovascular system of hypothyroidism patients for physical loading].

Twenty-one patients with primary hypothyroidism were subjected to electro- and echocardiography, and 10 patients, to bicycle ergometry, to examine their central and intracardiac hemodynamics at rest and cardiovascular response to exercise. The results were compared with the respective parameters of 18 normal subjects. Hypothyroidism was shown to be associated with increased left-ventricular myocardial weight (echocardiographic evidence in the presence of normal myocardial contractility at rest, lowered stress tolerance due to a smaller chronotropic reserve of the heart, and myocardial metabolic disorders.

Adult↗
PubMed1986

[Status of the cardiovascular system in patients with subacute thyroiditis].

In thirty patients with subacute thyroiditis the authors examined cardiovascular system with the use of the ECG as the most accessible and informative enough method. The clinical and ECG alterations were compared before and after the treatment with glucocorticoids. It was established that the patients with subacute thyroiditis had clinico-electrocardiographic alterations attesting to the presence of myocardiodystrophy. The alterations seen on the ECG mirrorred fully enough the impairment of the cardiovascular system. Myocardiodystrophies associated with subacute thyroiditis undergo reverse development as the remission of the underlying disease is attained as a result of specific therapy with glucocorticoids. This is confirmed by the electrocardiographic findings in the course of the treatment.

Adult↗
PubMedDate not supplied

[Physical working capacity and myocardial perfusion in patients with diabetes mellitus].

A study was made of the interrelationship of myocardial perfusion with physical working capacity in different types of DM (with the duration of disease from 4 to 8 years without clinical signs of circulatory insufficiency). Rated physical exercise testing in 12 patients with insulin dependent diabetes and 27 patients with noninsulin dependent diabetes as well as in 40 healthy subjects has shown a GTT decrease in diabetes mellitus irrespective of patient's age, sex and body mass to be more marked in noninsulin dependent type and to be closely related to disturbed oxygen supply of the heart and a lowered myocardial reserve. Bicycle ergometric testing combined with 201Tl scintigraphy in 20 patients has shown disorder of perfusion in all the patients irrespective of a diabetes type and duration of disease. Insulin dependent diabetes mellitus was characterized by stable perfusion defects resulting from metabolic derangements, and noninsulin dependent diabetes mellitus was characterized by a decrease in the level of a maximum Tl uptake by the myocardium and transient perfusion defects of ischemic type.

Adult↗
PubMedDate not supplied

[The rehabilitation of patients with diabetes mellitus and ischemic heart disease].

The results of bicycle ergometry testing were studied in 20 patients with diabetes mellitus of type II without clinical signs of circulatory insufficiency, 21 patients with postinfarction cardiosclerosis with undisturbed carbohydrate tolerance, and in 18 healthy persons. The blood level of glucose in patients with diabetes mellitus was investigated on an empty stomach and 30, 60 and 120 min. after physical exercising. Similar changes of bicycle ergometry results were found in diabetic and CHD patients. In compensation of diabetes in response to graded physical exercise glycemic changes were absent, in decompensation glycemia increased in 30 and 60 min. and returned to the basal level 120 min. after testing. Since the results of bicycle exercises in diabetic (compensated) and CHD patients were the same, the principles of their physical rehabilitation must be identical. In patients with decompensated diabetes mellitus a hyperglycemic reaction to graded physical exercise serves the basis for reduction of motor activity in patients with decompensated diabetes mellitus.

Adult↗
PubMedDate not supplied

[Insulinotropic effect of diamicron after oral fructose tolerance test in patients with non-insulin-dependent diabetes mellitus].

Insulinotropic action of glucose after a glucose tolerance test and fructose after a fructose tolerance test as well as insulinotropic and hypoglycemic effects of diamicron were examined in 21 patients with type II diabetes mellitus. The data obtained indicate that insulinotropic and hyperglycemic activity of fructose yields to that of glucose. Apart from increasing insulin concentration in the blood, diamicron enhances glucose utilization at the periphery.

Adult↗
PubMedDate not supplied

[Comparative evaluation of the hypoglycemic effect of the 2d-generation sulfonylurea preparations maninil and diamicron in diabetes mellitus].

Glycemia level and diurnal glucosuria were studied in the morning, afternoon and evening in a group of 27 patients with insulin-dependent diabetes mellitus before and after diamicron therapy for 1.5 to 3 months. A similar investigation was performed in a group of 20 patients, suffering from diabetes mellitus of the second type before and following maninil treatment during 1.5 to 2 months. It was shown that diamicron exerts a more pronounced sugar-lowering effect in comparison with that of maninil. It promotes stable glycemia development and should take an appropriate place among hypoglycemics used now in diabetology.

Adult↗