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Biomedical subjects

S A Seleznev

Publications and source records attributed to S A Seleznev.

At least 37 records · Page 2Linked to original sources
PubMedDate not supplied

[Application of the principles of the systemic approach to interpretation of the pathogenesis of traumatic shock and traumatic disease].

Experimental and clinical studies for many years led the authors to the conclusion that systemic approach seems most adequate for current interpretation of pathogenesis of traumatic disease (TD) and its component--traumatic shock (TS). It seems valid to assess TD and TS severity and dynamics by the proportion of pathological and adaptive reactions. Drugs should be used for maintenance and stimulation of adaptive reactions. Strong correlations of dynamics and severity of TD and TS enable prediction of TD course and outcome in acute period by time criterion (+)-T and distinguish three degrees of TD severity as well as evaluation of probability of favorable or unfavorable (lethal) outcome.

Adaptation, Physiological↗
PubMedDate not supplied

Origin of amphiphilic molecules and their role in primary structure formation.

Attempts to solve two fundamental questions are described: the first concerns which mechanisms were responsible for the self-assembly of membrane structures on the prebiotic Earth, and the second concerns the routes by which considerable amounts of membrane amphiphiles formed from simpler hydrocarbons. The physicochemical properties of several amphiphilic compounds extracted from the Murchison carbonaceous chondrite were studied, using infra-red and fluorescent spectroscopy, measurements of surface activity, chromato-mass spectrometry, and polarization and electron microscopy. The results supported previous observations that amphiphilic and aromatic hydrocarbons were present in significant quantities, and the first demonstration of surface activity among a number of acidic derivatives of hydrocarbons is reported. In addition, one fraction of the surface-active compounds can form bilayer structures, showing that membranes could have self-assembled on the prebiotic Earth. Photochemical oxidation of hydrocarbons is shown to be a likely source of the amphiphilic molecules required for the self-assembly of primary membrane structures.

Atmosphere↗
PubMedDate not supplied

[Common and peculiar features of the interaction of hemoglobins with hydrated dipalmitoyllecithin].

It was demonstrated that human and horse hemoglobin variants having quantitative difference in the interaction with dipalmitoyllecithin exhibit features of generality. The latter is manifested in the established hydrophobic contacts between protein and lipid in hydrated films discovered by IR spectroscopy. The arrangement of hydrophobicity profiles of hemoproteins demonstrated in amino acid sequences of chains the existence of intermittent hydrophobic and hydrophilic regions. Such a composition of hemoglobins could underlie their property to participate in hydrophobic interactions with lipids.

1,2-Dipalmitoylphosphatidylcholine↗
PubMedDate not supplied

[Low-angle x-ray diffraction of the erythrocyte membrane].

Using low-angle X-ray diffraction technique it has been shown that preparing procedures can induce the phase separation in red blood cell membranes in the course of which proteins are removed from lipid bilayers. The latter form rather extensive regions and the diffraction pattern of asymmetric type changes to a symmetric one.

Animals↗