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Biomedical subjects

S A Schmidt

Publications and source records attributed to S A Schmidt.

34 records · Page 2Linked to original sources
PubMed1988

A new method of estimation of interobserver variation and its application to the radiological assessment of osteoarthrosis in hip joints.

Four frequently referenced radiological methods for assessment of osteoarthrosis in hip joints are compared with respect to their interobserver variation. One hundred hip joints were rated by four observers. Each observer applied all four methods to all the radiographs. The results were analysed by a new statistical method, which allowed detailed assessment of the nature and extent of interobserver variation. Significant differences in terms of intraobserver disagreement were found, and Heripret's method was the best in this respect. All four methods showed a significant degree of systematic disagreement among the observers. This suggests that the interobserver variation might be reduced by confronting the observers with the results of the statistical analysis of their judgements.

Bone Diseases↗
PubMed1988

Indomethacin inhibits the recurrence of excised ectopic ossification after hip arthroplasty. A 3-4 year follow-up of 8 cases.

Eight patients were treated with indomethacin and excision of paraarticular ossification after hip arthroplasty. In 1986 we reported that after 3 months substantial ossification had recurred in only 2 patients. We now report that ossification had not progressed further at follow-up 3-4 years later. All 8 patients were painfree and the majority had good hip motion. We conclude that indomethacin permanently prevents recurrence after excision of paraarticular ossification.

Aged↗
PubMed1988

The use of indomethacin to prevent the formation of heterotopic bone after total hip replacement. A randomized, double-blind clinical trial.

We studied the effect of indomethacin on the prevention of formation of heterotopic bone after total hip replacement. In a randomized, double-blind clinical trial involving 201 patients, 102 patients received twenty-five milligrams of indomethacin three times daily for the first six postoperative weeks, and the other ninety-nine patients received a placebo. One year after the operation, eighty-nine of those who had received indomethacin had no sign of heterotopic ossification, and the remaining thirteen had a grade-I lesion. In the group that had received a placebo, twenty-seven had no heterotopic ossification; twenty-four, a grade-I lesion; thirty, a grade-II lesion; and eighteen, a grade-III lesion. Significantly fewer patients who had received indomethacin had formation of heterotopic bone compared with those who had been given a placebo (chi-square test, p less than 0.0005). Only patients who had grade-III formation of heterotopic bone had a significant reduction in movement of the hip.

Adult↗
PubMed1988

Serum alkaline phosphatase as an indicator of heterotopic bone formation following total hip arthroplasty.

Serum alkaline phosphatase (SAP) was analyzed in 193 patients treated with total hip arthroplasty (THA) and correlated with the degree of heterotopic bone formation (HBF) one year after surgery. The influence of indomethacin on changes in SAP related to the development of heterotopic bone was studied. Ninety-eight patients received 25 mg of indomethacin three times daily for the first six postoperative weeks; the remaining 95 patients received a placebo treatment. No further anti-inflammatory drugs were allowed during the six weeks. SAP was measured preoperatively and six weeks and 12 weeks after surgery. No patients at risk for developing heterotopic bone after THA could be identified from the preoperative level of SAP. The level of SAP six weeks after THA gradually increased with the amount of HBF. A rise in SAP above 250 IU/liter 12 weeks after surgery was associated with the development of severe heterotopic bone in 13 of 17 patients. Indomethacin inhibited the development of heterotopic bone associated with a rise in SAP following THA. Future studies on HBF and SAP following THA should include information on patient use of anti-inflammatory drugs in the early postoperative period.

Adult↗
PubMed1986

Indomethacin for prevention of ectopic ossification after hip arthroplasty.

Twelve patients at risk of developing postoperative para-articular ossifications were treated with indomethacin. Ossification after previous total hip arthroplasty was excised in eight patients. Four patients had ossification in the opposite hip after previous arthroplasty. Five patients in whom ectopic ossification was excised developed recurrences of lesser degree than the primary ossifications. One patient with the condition in the opposite hip developed ossification. No patients complained of stiffness in the hip and all had markedly increased hip motion. Indomethacin seems to be valuable as prophylaxis in patients at risk of developing ectopic ossification and as a supplement to secondary excision.

Aged↗