Tandem arrangement of genes coding for tumor necrosis factor (TNF-alpha) and lymphotoxin (TNF-beta) in the human genome.
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Animals↗
Biomedical subjects
S A Filippov
Publications and source records attributed to S A Filippov.
[Plasmid vectors pBBV for the cloning and regeneration of DNA fragments with any terminal nucleotide sequence].
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Base Sequence↗
DNA H form requires a homopurine-homopyrimidine mirror repeat.
Regular homopurine-homopyrimidine tracts, (dG-dA)n(dT-dC)n and (dG)n(dC)n, undergo a superhelix-induced, strongly pH-dependent, structural transition into a novel DNA conformation, the H form. We have suggested that the H form can arise in any homopurine-homopyrimidine mirror repeat (H palindrome). We have now tested this prediction using a tailored series of plasmids carrying the inserts AAGGGAGAAXGGGGTATAGGGGYAAGAGGGAA, where X and Y may be either A or G, and subject them to two-dimensional gel electrophoresis. In support of our hypothesis, the inserts exhibited facile transitions into the H form for X = Y = G, or X = Y = A, whereas the transition was much more difficult or impossible for the two non-palindromes (X = A, Y = G or X = G, Y = A). We present evidence that the H form is the structural basis for S1-nuclease hypersensitivity.
Animals↗
[Synthetic promotor P25 of bacteriophage T5 and its functional hybrids with the model promotor of Escherichia coli].
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Base Sequence↗