Breast imaging case of the day. Spontaneously disappearing benign calcifications of the breast.
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Breast↗
Biomedical subjects
S A Feig
Publications and source records attributed to S A Feig.
Unrelated donor bone marrow transplants in children.
Only a small proportion of children who might benefit from bone marrow transplant (BMT) have an HLA-identical sibling. To provide this potentially curative therapy to patients without a matched related donor, marrow transplants using less well matched related donors or unrelated donors (identified through computerized donor registries) have been performed. We report the outcome of 24 consecutive unrelated donor BMT's performed on children. Eligible diagnosis included acute leukemia (AL) (n = 15), chronic myelogenous leukemia (CML) (n = 4), myelodysplastic syndrome (MDS) (n = 3), and severe aplastic anemia (SAA) (n = 2). All donor/recipient pairs were sero-matched at 5 or 6 of the 6 HLA A, B, and DR antigens. Several different preparative regimens were used, but fractionated total body irradiation (TBI) was used in 20 patients. All recipients received graft-versus-host-disease (GVHD) prophylaxis with cyclosporine-A (CSA), four with short course methotrexate (MTX), 14 in combination with short course MTX and methylprednisolone (MPS), and five in combination with a mouse monoclonal antibody to CD5, coupled to the A-chain of ricin (Xomazyme-65). One patient received CSA and MPS alone after a T-cell depleted marrow transplant. Twenty of 23 evaluable recipients engrafted (87%). Two patients with CML never engrafted and had autologous marrow recovery, one patient with SAA died at 128 days without evidence of engraftment, and there was one early death at day + 9. Fourteen of 20 patients (70%) with stable donor-derived hematopoiesis developed significant acute GVHD > or = grade II). Eleven of 15 engrafted patients who survived > 100 days after BMT developed chronic GVHD (73%).(ABSTRACT TRUNCATED AT 250 WORDS)
Adolescent↗
Case report: progressive systemic sclerosis-like syndrome after bone marrow transplantation. Clinical, immunologic, and pathologic findings.
A young man developed chronic graft-versus-host disease (GvHD) after allogeneic bone marrow transplantation. The close resemblance of his skin changes to those of patients with progressive systemic sclerosis (PSS) prompted an examination for clinical and pathologic involvement of other organ systems. Many of the dermatologic, cardiac, renal and pulmonary findings in the transplant patient were similar to those seen in a comparison group of 38 patients with PSS.
Adolescent↗
Thermography in breast cancer screening: progress and prospects.
The use of thermography in breast cancer detection is reviewed. Although advantageous in its total lack of radiation exposure to the patient, thermography has limitations in that significant false-positive and false-negative cancer detection rates have been demonstrated. The potential use of thermography in evaluation of the pathogenesis of breast cancer and in identifying women at high risk is discussed.
Breast Neoplasms↗