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Biomedical subjects

S A Duffy

Publications and source records attributed to S A Duffy.

21 records · Page 2Linked to original sources

Comprehension of synthetic speech produced by rule: a review and theoretical interpretation.

In this paper, we review research on the perception and comprehension of synthetic speech produced by rule. We discuss the difficulties that synthetic speech causes for the listener and the evidence that the immediate result of those difficulties is a delay in the point at which words are recognized. We then argue that this delay in processing affects not only lexical access but also comprehension processes. We consider the mechanisms by which the comprehension system adjusts to this delay, the resulting costs to higher level comprehension processes, and the changes that occur in the language processing system as its familiarity with synthetic speech increases. Based on the framework we have developed, we suggest several directions for future research on the comprehension of synthetic speech.

Female↗

The recovery of highly purified biopharmaceuticals from perfusion cell culture bioreactors.

The impact of continuous perfusion cell culture technology on production of one and two chain human rtPA, as well as monoclonal IgG and IgM, will be reviewed. Perfusion as compared to batch systems improve the quality of the product in the conditioned media in terms of biological activity and structural integrity. This significantly increases downstream recovery and daily production output of final purified material. These findings are a consequence of the ability of perfusion technology to 1) maintain cells intact at high cell density; 2) effectively reduce serum content to approximate serum free conditions; and 3) minimize residency time of labile product within the 37 degrees C environment of the bioreactor.

Biological Products↗