Schizophrenia and rheumatoid arthritis.
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Arthritis, Rheumatoid↗
Biomedical subjects
S A Checkley
Publications and source records attributed to S A Checkley.
Hormone responses to methylamphetamine in depression: a new approach to the noradrenaline depletion hypothesis.
The corticosteroid response to methylamphetamine was lower in ten patients when they were depressed than when they were recovered (P less than .026). The growth hormone responses to the same injection in the depressed and recovered states were not significantly different. This pattern of responses is seen in normal subjects after blockade of alpha adrenergic receptors. These findings may indicate a functional deficiency of noradrenaline at alpha adrenergic receptors in these patients during the time they are depressed.
Adrenal Cortex Hormones↗
Effects of sex steroids on protein synthesis in cultured human lymphocytes.
In cultured human lymphocytes, oestrogen and progesterone at concentrations found in plasma during the normal menstrual cycle, significantly increase the incorporation of [35S] methionine into protein and, in addition, both hormones significantly alter the relative synthesis of certain proteins. At concentrations found in plasma during pregnancy, some changes are augmented while others are reversed. These specific sex-steroid-induced changes in protein synthesis provide possible peripheral biological markers of hormone action which may be tested for their association with predisposition to, and/or onset of, conditions such as postpartum psychiatric illness.
Adult↗