Biomedical subjects

S A Adebisi

Publications and source records attributed to S A Adebisi.

7 recordsLinked to original sources

PubMed2005

Permanent hypoparathyroidism developing post-thyroidectomy.

A case of permanent hypocalcaemia following a subtotal thyroidectomy for a simple multinodular goiter in a 35 year -- old married teacher is presented. This further confirms the need for utmost precaution during thyroid surgery to prevent the damage or inadvertent removal of the parathyroid glands and its consequential complications. It also throws more light on the problem faced in the management of hypocalcaemia vis a vis patient compliance and availability of proper medications in this environment.

Adult↗

PubMed2004

Awareness of atherosclerosis risk factors in Nigeria.

Non-communicable diseases, which include hypertension and diabetes mellitus, have become an important cause of morbidity and mortality in Nigeria. The determination of serum lipid levels is used routinely to assess the risk of atherosclerosis. This study was performed in order to determine the frequency of serum lipid requests in the community. Information on both lipid and total chemical pathology requests for the study period (May 1998 to April 2000) was obtained from the Department of Chemical Pathology, University of Ilorin Teaching Hospital, whilst data on the total hospital attendance was obtained from the hospital's Record Department. The number of serum lipid requests increased from year to year (May 1998 to April 1999 = 780; May 1999 to April 2000 = 1,357; May 2000 to April 2001 = 1,382). The percentages of total requests for serum Lipids when compared with the total laboratory requests for the period of study were 12.0%, 13.3% and 14.0% for the first, second and third year respectively. More men than women had their serum lipid levels determined; 31.3% of the patients had hyper-cholesterolaemia (> 5.2 mmol/L), while 9.9% had values > or = 6.2 mmol/L. Industrial disputes (strikes) affected our results. For the three-year period there was no remarkable increase in the use of the lipid profile facilities available in the centre. This reflects the inadequate awareness of lipid disorders as a risk factor for atherosclerosis.

Arteriosclerosis↗

PubMed2004

Plasma lipids and lipoproteins during first trimester in pregnant Nigerian women: Ilorin experience.

Thirty-two pregnant women in their first trimester with a mean age of 29.5 years, 32 age matched non-pregnant controls were included in this study. They were bled after 14-hour fasting. This study was between October 2000 and October 2001. Plasma total cholesterol, triglyceride and HDL- cholesterol were assayed. LDL-cholesterol was obtained through Frieldwald formula average as mean were calculated using Epi info version 6.0 and level of significant difference decided at p<0. 05. The mean age of the subjects was 9.5 years. Compared to the concentration in non-pregnant women [controls] the plasma level of total cholesterol and HDL-cholesterol were found to be significantly lower p<0.05. However the levels of plasma triglyceride and LDL-cholesterol were found to be significantly higher in the pregnant women than the control group [p<0.05]. This study revealed that the level of total plasma cholesterol is low in middle part of first trimester. We therefore suggest that in interpreting the result of total cholesterol in first trimester the gestation age should be put into consideration.

Adult↗

PubMed2003

Glycated haemoglobin and associated variables in diabetics: Ilorin experience.

One hundred and fifty type 2 diabetes mellitus patients were investigated to determine extent of haemoglobin glycation and factors that might influence it. Factors so considered were age, sex, disease duration, and body mass index. The mean HbA(1c) was 8.0%. Ninety-six (about 64%) of the subjects had HbA(1c) > 7.2%. Seventy-one of these were males. Sex and age did not have significant effect on HbA(1c) and so was disease duration in our center. Almost 70% of the female diabetics were overweight. Correlation was very poor between BMI and haemoglobin glycation. However, assessment of the individual group results tended to suggest that glycation decrease with increasing BMI.

Adult↗

PubMed2003

The usefulness of serum albumin and urinary creatinine as biochemical indices for monitoring the nutritional status of Nigerians with pulmonary tuberculosis.

The objective is to evaluate the relative roles of urinary creatinine and serum albumin as biochemical markers for monitoring the nutritional status of pulmonary tuberculosis patients during treatment. Thirty-one newly diagnosed pulmonary tuberculosis patients were placed on six months short course regimen. Their weight, body mass index, serum albumin and 24-hour urinary creatinine excretion were determined before treatment, at the end of the 1st, 2nd, 4th and 6th month of treatment. Subjecting the mean values of the weight, BMI and Urinary Creatinine excretion and serum albumin to Friedman test showed significant changes for all the four indices. Further analysis with paired student t-test of the pre-treatment values with end of 6th month values confirmed significant changes in the mean values of weight, BMI and serum albumin. Of these three indices serum albumin with chi-square value of 103.515 demonstrated the most significant changes, while the minimal change observed in urinary creatinine excretion could not be confirmed with paired t-test. We recommend serum albumin (as a more sensitive index) for monitoring the nutrition of patient with pulmonary tuberculosis.

Biomarkers↗

PubMedDate not supplied

Effect of drug-induced hyperuricaemia on renal function in Nigerians with pulmonary tuberculosis.

Some anti-tuberculosis chemotherapeutic agents have been established as causing hyperuricaemia. Hyperuricaemia in turn causes renal damage. This study therefore aims at establishing the effect of anti-tuberculosis drugs-induced hyperuricaemia on renal function of the patients. Fifty patients with newly diagnosed pulmonary tuberculosis with mean age of 36.8 years (SD 13.69) consisting of 14 females and 17 males were longitudinally studied each for 6 months to determine the effect of drug-induced hyperuricaemia on their renal function. The Biochemical indices determined included serum urate level, serum creatinine level, and creatinine clearance of newly diagnosed patient with tuberculosis, before and during treatment with anti-tuberculosis therapy. Serum urate level revealed that 16 (51.6%) and 15 (48.4%) of the patients were hyperuricaemic at the end of the first and second months of anti-tuberculosis therapy. There was no significant difference in the mean serum creatinine level of the control group 96 micromol/L when compared with both the pre-treat value 89 micromol/L (P > 0.25) as well as the value at the end of the sixth month of treatment 91 micromol/L (P > 0.40). However, there was a statistically significant difference in the mean creatinine clearance of the control group 102 ml/min/1.73 m2 when compared with the patient's mean pre-treatment value (89 ml/min/1.73 m2) P < 0.05. Also the mean creatinine clearance increased to (103 ml/min/1.73 m2) by the end of the 6th month of treatment, a value that is statistically significant when compared with the pretreatment value of (89 ml/min/1.73 m2) P < 0.05. We submit as follows: that pulmonary tuberculosis as a disease with significant impairment of renal function; despite the associated drug-induced hyperuricaemia recorded during the treatment, renal function steadily improved with the treatment of pulmonary tuberculosis to the extent that comparable values with control was obtained at the end of treatment. We conclude therefore that drug-induced hyperuricaemia associated with treatment of pulmonary tuberculosis has no detectable negative effect on renal function of the patient.

Adult↗

PubMedDate not supplied

Creatinine clearance: alternative approach to traditional 24-hour urine collection in normal individuals.

Clinically, the commonly used routine test for assessing impaired renal function is the determination of creatinine clearance. The traditional 24 hour urine collection method is unreliable and inconvenient, particularly in ambulatory patients and outpatients because of errors in collection, timing of collection, and measurement of urine volume. The purpose of this study was to evaluate the possibility of determining creatinine clearance from urine collected for less than the traditional 24 hours. Thirty clinically healthy adult subjects with no history of renal dysfunction were used for the study. Each of the subjects had his creatinine clearance determined from 4 hour, 20 hour and 24 hour urine collections as well as from the formula of Cockcroft and Gault. The mean creatinine clearance obtained from 4 hour urine collection (male = 92.8 ml/ min/1.73 m2 & female = 84.5 ml/min/1.73 m2) and 20 hour urine collection (male = 98.9 ml/min/1.73 m2 & female = 88.6 ml/min/1.73 m2) shows no significant difference from that obtained from the traditional 24 hour urine collection (male = 97.9 ml/min/1.73 m2 & female = 88.1 ml/min/1.73 m2) (P > 0.05). We therefore suggest that determination of creatinine clearance from fewer hours of urine collection especially in patients with renal impairment be explored towards their adaptation to routine practice.

Adult↗