Biomedical subjects

Rudolf Fahlbusch

Publications and source records attributed to Rudolf Fahlbusch.

At least 55 records · Page 3Linked to original sources

PubMed2004

Integration of biochemical images of a tumor into frameless stereotaxy achieved using a magnetic resonance imaging/magnetic resonance spectroscopy hybrid data set.

OBJECT: It is often difficult to delineate the extent of invasion of high- and low-grade gliomas into normal brain tissue by using conventional T1- and T2-weighted magnetic resonance (MR) imaging. Knowledge of the relationship between the tumor infiltration zone and normal brain, however, is one of the prerequisites for performing as radical a tumor resection as possible. Proton MR spectroscopy allows noninvasive measurements of the concentrations and spatial distributions of brain metabolites and, therefore, may provide biochemical information in vivo, that is useful in distinguishing pathological from normal areas of the brain. The authors have developed a method to use the properties of MR spectroscopy to investigate intraoperatively pathological changes in the spatial distribution of choline (Cho)-containing compounds, total creatine, and N-acetylaspartate (NAA) in brain tumors with the aid of frameless stereotaxy. METHODS: Maps of the Cho/NAA ratio were calculated and automatic segmentation of the tumors was performed. Spectroscopic images of the segmented tumor were matched to an anatomical three-dimensional (3D) MR imaging set by applying a fully automated mutual-information algorithm. The resulting 3D MR image can be used subsequently for neurosurgical planning, transfer to a frameless stereotactic system, and display in the navigation microscope during surgery leading to 1H-MR spectroscopy-guided navigation. CONCLUSIONS: This method may allow better intraoperative identification of tumor border zones based on metabolic changes due to tumor infiltration.

Brain Neoplasms↗

PubMed2003

Analysis and 3-dimensional visualization of neurovascular compression syndromes.

RATIONALE AND OBJECTIVES: Neurovascular compression syndromes are currently examined with 2-dimensional representations of tomographic volumes. To overcome this drawback, coarse segmentation followed by direct volume rendering of magnetic resonance (MR) data is introduced supporting a detailed 3-dimensional analysis of the related structures. MATERIALS AND METHODS: This approach is based on MR-CISS (constructive interference in steady state) volumes providing the required high resolution to achieve an improved spatial understanding. In relation to the size of the involved nerves and vessels, an explicit segmentation is extremely difficult. Therefore, a semi-automatic preprocessing sequence was developed consisting of noise reduction, morphologic filtering, and volume growing. To delineate the target structures within the segmented and labeled subvolumes, interactive direct volume rendering was applied that allows delineating the target structures in the area of the cerebrospinal fluid with implicit segmentation based on predefined transfer functions assigning opacity and color values to the intensity values of the image data. For a further improved analysis, registration of the MR-CISS volumes with MR angiography is recommended to support differentiating vessels and nerves on the one side and arteries and veins on the other. RESULTS: The presented method was applied in a consecutive series of 47 cases of different neurovascular compression syndromes, supporting the presurgical analysis of the image data. Additionally, the results were compared with the operative findings. CONCLUSION: Overall, this approach contributes significantly to an optimized 3-dimensional analysis and understanding of neurovascular compression syndromes. Based on the obtained results, it is of high value for the planning of surgery.

Constriction, Pathologic↗

PubMed2003

Intraoperative Image-Guided Surgery of the Lateral and Anterior Skull Base in Patients with Tumors or Trauma.

The aim of this investigation was to evaluate the suitability and usefulness of the Stealth Stationtrade mark intraoperative guiding system (Medtronic Sofamor Danek, Memphis, TN) in a variety of indications. Eleven intraoperative image-guided procedures were performed for anterior or lateral skull base lesions. The most common neurosurgical approaches included frontal, coronal, and parietotemporal access. Neuronavigation reliably allowed the extent of tumor configuration and risk zones (e.g., blood vessels) to be visualized. Thus, gross tumor resection was achieved in 6 of 7 patients and facilitated reconstruction by the maxillofacial surgeon, resulting in radiologically symmetrical and clinically satisfying results. Postoperatively, one patient was blind from a continuity defect of the optic nerve caused by a bone fragment. Despite destruction of anatomical landmarks related to tumor invasion or intraoperative bone removal, neuronavigation proved helpful in the reconstruction of bony structures. Overall, the use of neuronavigation in interdisciplinary surgery for complicated tumors or trauma of the anterior or lateral skull base allows more radical resection associated with less morbidity.

Journal Article↗

PubMed2003

Anesthesia during high-field intraoperative magnetic resonance imaging experience with 80 consecutive cases.

Intraoperative magnetic resonance imaging (MRI) has been used for years to update neuronavigation and for intraoperative resection control. For this purpose, low-field (0.1-0.2 T) MR scanners have been installed in the operating room, which, in contrast to machines using higher magnetic field strength, allowed the use of standard anesthetic and surgical equipment. However, these low-field MR systems provided only minor image quality and a limited battery of MR sequences, excluding functional MRI, diffusion-weighted MRI, or MR angiography and spectroscopy. Based on these advantages, a concept using high-field MRI (1.5 T) with intraoperative functional neuronavigational guidance has been developed that required adaptation of the anesthetic regimen to working in the close vicinity to the strong magnetic field. In this paper the authors present their experience with the first 80 consecutive patients who received anesthesia in a specially designed radio frequency-shielded operating room equipped with a high-field (1.5 T) MR scanner. We describe the MR-compatible anesthesia equipment used including ventilator, monitoring, and syringe pumps, which allow standard neuroanesthesia in this new and challenging environment. This equipment provides the use of total intravenous anesthesia with propofol and remifentanil allowing rapid extubation and neurologic examination following surgery. In addition, extended intraoperative monitoring including EEG monitoring required for intracranial surgery is possible. Moreover, problems and dangers related to the effects of the strong magnetic field are discussed.

Adolescent↗

PubMed2003

Intraoperative low-field magnetic resonance imaging in pediatric neurosurgery.

BACKGROUND: Since the mid-1990s, the feasibility and indications of intraoperative magnetic resonance (MR) imaging have been investigated by different groups. The majority of examinations were carried out in adults. The aim of this study was to summarize our experience of over 5 years of intraoperative MR imaging in pediatric neurosurgery. METHODS: For scanning, we used a 0.2-Tesla Magnetom Open, which was placed in a radiofrequency-shielded twin operating theater, allowing surgery with standard instruments and additional neuronavigational guidance either in an adjacent operating room or directly in the radiofrequency cabin on the extended MR table, at the 5-G line. RESULTS: In total, 330 patients were investigated, among them 33 children who were younger than 17 years. We found four main indications for intraoperative MR imaging: the evaluation of cyst drainage (n = 9), of the extent of resection in epilepsy surgery (n = 6) and of the removal of pituitary tumors (n = 6) and gliomas and other brain tumors (n = 12). Intraoperative MR imaging allowed us to evaluate the extent of the resection or to monitor catheter placements and consecutive cyst alterations in all cases. In 2 tumor cases and 3 catheter placements, intraoperative imaging resulted in a modification of the surgical strategy. CONCLUSIONS: Intraoperative low-field MR imaging is a safe procedure; we did not encounter an increased morbidity in the children investigated. It serves as intraoperative quality control documenting the effects of surgery, e.g. the extent of a resection, which can then be compared to the treatment plan. Besides its most essential application in brain tumors, it also proved to be particularly helpful in children undergoing complicated catheter placements for cyst drainage, as well as in pituitary and epilepsy surgery.

Adolescent↗

PubMed2003

Limited benefit of intraoperative low-field magnetic resonance imaging in craniopharyngioma surgery.

OBJECTIVE: To investigate the benefit of intraoperative low-field magnetic resonance imaging (MRI) in craniopharyngioma surgery. METHODS: We used a 0.2-T Magnetom Open scanner (Siemens Medical Solutions, Erlangen, Germany) that was located in a radiofrequency-shielded operating theater for intraoperative MRI. The head of the patient was placed in the fringe field of the scanner, so that standard microinstruments could be used. In transsphenoidal surgery, T1-weighted coronal and sagittal images were acquired. In transcranial surgery, a three-dimensional, gradient echo, T1-weighted, fast low-angle shot sequence was measured, thus allowing multiplanar reformatting. RESULTS: A total of 21 surgical procedures in craniopharyngioma patients were investigated. In 10 patients, a bifrontal-translaminar approach was used; in 6 patients, the craniopharyngioma was removed via a transsphenoidal approach; and in 5 patients, intraoperative MRI was used to monitor cyst puncture and aspiration. In the craniotomy group, intraoperative imaging depicted a clear tumor remnant in one patient, which was subsequently removed. In another patient, an area of contrast enhancement was interpreted as artifact; however, postoperative follow-up at 3 months was suspicious for a minor remnant. Two of the eight patients with complete removal developed a recurrence during the follow-up period. In the group of patients who underwent primary transsphenoidal surgery (n = 4), complete removal was estimated by the surgeon in three cases. Intraoperative imaging depicted a remaining tumor in one case, leading to further tumor removal; however, follow-up revealed recurrent cysts. CONCLUSION: Intraoperative low-field MRI allows an ultraearly evaluation of the extent of tumor removal in craniopharyngioma surgery in most cases. Imaging showing an incomplete resection offers the chance for further tumor removal during the same operation. However, intraoperative low-field MRI depicting a complete resection does not exclude craniopharyngioma recurrence.

Adolescent↗

PubMed2003

Hormone markers in pituitary adenomas: changes within last decade resulting from improved method.

The significance of polyclonal antibodies for demonstration of hormone expression in pituitary adenomas was compared with the significance of monoclonal antibodies (MAbs). Adenomas were classified by light microscopic structures in paraffin- and epon-embedded sections, by immunostaining for all pituitary hormones, and in part by electron microscopy. In the first series, 166 adenomas were studied with polyclonal antibodies during 1990 and 1991. In the second series, 572 adenomas were immunostained with MAbs during 1999 and 2000. In the first series, a very typical type-specific hormone expression was demonstrable in 63.2% of adenomas in contrast to 91.1% in the second series. Consequently, in the first series 36.7% of adenomas expressed additional or atypical hormones in >10% of adenoma cells, whereas in the second series only 8.9% contained additional hormones. We conclude that MAbs show a clearer cutoff in immunostainings of pituitary hormones and therefore should be preferred for adenoma classification.

Adenoma↗

PubMed2003

Remote computing environment compensating for brain shift.

OBJECTIVE: Anatomical and functional image data become invalid during an operation due to brain shift. Compensation is achieved by using intraoperative imaging to update anatomical information. To accelerate the registration and visualization of pre- and intraoperative image data, the presented work focuses on remote computing capabilities. The underlying framework efficiently combines local desktop computers and remote high-end graphics workstations exploiting expensive hardware. METHODS: By performing all computations on the remote computer, the MR volumes are rigidly aligned via voxel-based registration. Using graphics hardware for acceleration, all interpolation operations are performed with 3D texture-mapping hardware. A new approach then transforms functional markers from preoperative measurements to the intraoperative situation using an automatic tracking algorithm to identify corresponding sulci. Communicating Java viewers are suggested for analyzing the results interactively on a local computer, with all calculations being performed exclusively on the remote computer. RESULTS: The suggested approach was successfully applied in 5 cases using MR data containing functional markers of MEG and fMRI measurements identifying eloquent brain areas. Remote large-scale graphics hardware was thereby efficiently made available for fast registration and interactive direct volume rendering in neurosurgery. CONCLUSION: Overall, the presented framework demonstrates efficient access of expensive high-end hardware remotely controlled by thin clients, and further emphasizes the need to compensate for brain shift in functional neuronavigation.

Brain↗

PubMed2003

Fast and adaptive finite element approach for modeling brain shift.

OBJECTIVE: In this paper we introduce a finite element-based strategy for simulation of brain deformation occurring during neurosurgery. The phenomenon, known as brain shift, causes a decrease in the accuracy of neuronavigation systems that rely on preoperatively acquired data. This can be compensated for with a computational model of the brain deformation process. By applying model calculations to preoperative images, an update within the operating room can be performed. METHODS: One of the crucial concerns in the context of developing a physical-based model is the choice of governing equations describing the physics of the phenomenon. In this work, deformation of brain tissue is expressed in terms of a 3D consolidation model for a linearly elastic and porous fluid. The next crucial issue is ensuring stable calculations within the chosen model. For this purpose, we developed a special technique for generating the underlying geometry for the simulation. With this technique an unstructured grid consisting of regular tetrahedra is created, whereupon time-dependent finite element simulation is performed in an adaptive manner. RESULTS: We applied our algorithm to preoperative MR scans and investigated the value of the method. Due to the adaptivity of the method, only 5-10% of the computing time was needed as compared to traditional finite element approaches based on a uniformly subdivided grid. The results of the experiments were compared to the corresponding intraoperative MR scans. A close match between the computed deformation of the brain and the displacement resulting from the intraoperative data was observed. CONCLUSION: A model-based approach for the simulation of brain shift is presented. In this computational model the brain tissue is described as an elastic and porous material using Biot consolidation theory. Validating experiments conducted with MR data provided promising results.

Algorithms↗

PubMed2003

Standardized 3D documentation for neurosurgery.

OBJECTIVE: Although direct volume visualization is now a standard tool for diagnosis and therapy planning for medical conditions in the brain, its application is normally restricted to radiological workstations. We propose the use of standardized digital video sequences which can be easily ported to mobile computing platforms and thereby to diverse clinical environments. The effectiveness of this approach is demonstrated in the operating room. MATERIALS AND METHODS: Segmented MR data corresponding to neurovascular compression syndrome pathologies was examined with 3D visualization based on tagged volumes. CT-angiography data containing aneurysms close to the skull base was analyzed with volume visualization based on bidimensional transfer functions. Furthermore, automatic adjustment of bidimensional transfer function templates was implemented. An extension of the applied volume visualization tool made it possible to standardize the creation of pathology-specific digital video sequences. RESULTS: Five cases of neurovascular compression syndromes and 4 cases of aneurysms close to the skull base were examined. One-dimensional transfer function templates were successfully applied for the visualization of neurovascular compression syndromes. Automatic adjustment of transfer function templates made it possible to achieve good-quality results for visualization of aneurysms without external adjustment. The resulting digital video sequences were successfully used in the operating room. CONCLUSION: The portability of the 3D video sequences broadens their application spectrum, making them adequate not only for database purposes, but also for surgical support and cooperative environments. Furthermore, the required technical knowledge is encapsulated, making this approach more suitable for clinical applications.

Humans↗

PubMed2002

Low-field magnetic resonance imaging for intraoperative use in neurosurgery: a 5-year experience.

The aim of this study was to evaluate the feasibility and point out the indications of intraoperative MR imaging in neurosurgical procedures. The MR imaging was performed using a 0.2-T scanner which was located in a radiofrequency-shielded operating theater. Three major setups for intraoperative imaging were possible: inside the scanner; at the 5-Gauss line; or in an adjacent operating theater. Additionally, in lesions adjacent to eloquent brain areas microscope- and pointer-based neuronavigation with integrated functional data was applied. Three hundred ten patients were investigated in the previous 5 years, among them gliomas ( n=95), pituitary tumors ( n=81), and 39 non-lesional cases in whom resective or disconnective epilepsy surgery was carried out. We did not observe any adverse effects due to intraoperative MR imaging. Image quality was sufficient to evaluate the extent of the tumor resection in the majority of cases. The main indications for intraoperative MR imaging were the evaluation of the extent of a resection in glioma, ventricular tumor, pituitary tumor, and in epilepsy surgery. Intraoperative MR imaging offers the possibility of further tumor removal during the same surgical procedure in case of tumor remnants, increasing the rate of complete tumor removal. Furthermore, the effects of brain shift, which would lead to inaccurate neuronavigation, can be compensated for by an update of the neuronavigation system with intraoperative MR image data.

Adult↗

PubMed2002

Laser Doppler flowmetry mapping of cerebrocortical microflow: characteristics and limitations.

The aim of this study was to quantitatively analyze the amount of methodological noise and the spatial and temporal variability of laser Doppler flowmetry (LDF) signals mapping cerebrocortical microflow. In an experimental setup with latex beads, the methodological LDF-signal variability was determined (coefficient of variation or CV(method)). The biological variability of the LDF signals was measured in animal experiments using 10 anesthetized rabbits. One stationary reference probe was used to assess temporal heterogeneity (CV(temp)) and a micromanipulator-driven scanning probe was used to assess spatial heterogeneity (CV(spat)) in a cortical area of 3.5 x 4.5 mm with 252 measurement points. CO(2) tests were used to modulate cerebrovascular resistance. CV(method) was found to be 4.94 +/- 1.7. The CV(temp) for the LDF-velocity signal was assessed to be 13.93 +/- 5.9 during normocapnia. Scanning of the brain surface with the scanning probe revealed a CV(spat) for LDF velocity of 65.0 +/- 16.2 during normocapnia. CO(2) modulation (hypocapnia --> normocapnia --> hypercapnia) of the cerebral resistance did not show a significant change in temporal heterogeneity (10.84 +/- 3.1 --> 13.93 +/- 5.9 --> 14.82 +/- 3.9), whereas spatial heterogeneity decreased significantly (81.31 +/- 12.0 --> 65.0 +/- 16.2 --> 54.04 +/- 21.8). Although the spatial and temporal variability of LDF signals evoked by cerebrocortical microflow is in the same range as with other methods and in other organs, LDF cerebrocortical mapping is restricted by the large temporal and spatial heterogeneity of the cerebrocortical vasculature. The definitions of sample volume, scanning step width, probe to brain surface distance, and average time per scanning point are critical concerning reliable LDF cerebrocortical mapping techniques.

Animals↗

PubMed2002

Increased menin expression in sporadic pituitary adenomas.

BACKGROUND: Germline mutations of the multiple endocrine neoplasia type 1 (MEN1) tumour-suppressor gene are responsible for multiple endocrine neoplasia type 1, and menin, the MEN1 gene product, is usually downregulated or truncated in MEN1-associated adenomas. In contrast, exonic MEN1 mutations seem to be very rare in sporadic (MEN1-unrelated) pituitary adenomas, and it has been suggested that menin does not play a major role in these tumours. However, menin might be involved in sporadic adenoma tumorigenesis by downregulation through intronic mutations, epigenetic, posttranscriptional or posttranslational mechanisms. PATIENTS AND MEASUREMENTS: We screened MEN1 coding regions and flanking intronic sequences of 136 sporadic pituitary adenomas by temporal temperature gradient gel electrophoresis (TTGE) and studied menin expression by immunoblotting in 11 of these tumours. RESULTS: Sequencing of DNAs showing aberrant migration on TTGE revealed five somatic MEN1 mutations, including two missense mutations (F134L, E530K), a 2-bp deletion in exon 10 (c.1567-1568del) leading to a premature stop codon, and two 3-bp deletions in intron 5 (g.5236-5238del, g.5237-5239del). These mutations have not been reported previously in studies analysing the MEN1 gene. Immunoblotting showed menin upregulation in all adenomas examined (including one case with a missense mutation) from 1.7-fold to 10.4-fold (mean, 4.2-fold) compared to non-neoplastic adenohypophysis. CONCLUSIONS: Our data suggest that neither MEN1 mutations nor menin downregulation play a significant role in the development of sporadic pituitary adenomas.

Adenoma↗

PubMed2002

Use of intraoperative magnetic resonance imaging in tailored temporal lobe surgeries for epilepsy.

PURPOSE: We investigated whether intraoperative magnetic resonance imaging (MRI) was able to assess immediately the extent of a tailored temporal lobe resection for epilepsy in comparison to delayed postoperative MRI. The recently proposed concept of an individually tailored procedure, preserving tissue not involved in seizures, leads to a variety of differently shaped resections. METHODS: For intraoperative imaging we used a Magnetom Open 0.2 Tesla scanner. Fifty-eight patients undergoing temporal lobe resections for pharmacoresistant epilepsy were investigated. Half of these were nonlesional. All patients had delayed postoperative follow-up scans, which were compared with the intraoperative, postresection images. RESULTS: In 49 (84%) of 58 cases, intraoperative MRI depicted the resection cavity identical to delayed postoperative studies. Complete resection of the visible lesion was primarily proved in 23 of the 29 cases. In two patients with lesions and in one nonlesional case, the resection was extended after intraoperative imaging, thus increasing the rate of total resections in gliomas from 73 to 87%. In four patients, an extension into eloquent areas did not allow complete removal. In the nonlesional cases (n = 29), the extent of tailored temporal resections also could be exactly documented intraoperatively. CONCLUSIONS: Intraoperative MRI allowed a reliable evaluation of the localization and extent of resection in epilepsy surgery within the operative procedure. Furthermore, it provided the possibility of an image-based correction of an initially incomplete resection, particularly in lesional cases. In the majority of patients, the intraoperative images would have been able to replace delayed postoperative MRI. However, in 16%, there were postoperative changes in the resection volume.

Adolescent↗

PubMed2002

Continuous cerebral autoregulation monitoring by cross-correlation analysis.

In order to validate cross-correlation analysis between spontaneous slow oscillations of arterial blood pressure (aBP) and intracranial pressure (ICP) or flow velocity as a means to assess the status of cerebral autoregulation continuously, we compared its results with different autoregulation bedside tests. The second aim was to check the method's stability over longer time periods. aBP, ICP, and flow velocity in the middle cerebral artery (FV(MCA)) was measured continuously in 13 critically ill comatose patients. Cross-correlation analysis was performed online and offline between aBP and ICP (CC [aBP --> ICP]) and aBP/FV(MCA) (CC [aBP --> FV(MCA)]). Three different autoregulation bedside tests (cuff deflation, transient hyperemic response, orthostatic hypotension) were performed immediately before a 29-min cross-correlation test period. In addition, continuous cross-correlation autoregulation monitoring was performed over multiple hours (in order to analyze for stability and to assess the influence of other factors). Cluster analysis revealed two main clusters. Cluster 1 (indicative for disturbed autoregulation) showed a centroid at t = -0.21 +/- 3.32 sec, r = 0.43 +/- 0.18 for CC [aBP --> ICP], and t = 0 +/- 3.14 sec, r = 0.44 +/- 0.18 for CC [aBP --> FV(MCA)]. Cluster 2 (indicative for normal autoregulation) revealed a centroid at t = 4.94 +/- 3.74 sec, r =- 0.4 +/- 0.16 for CC [aBP --> ICP], and t = 3.38 +/- 4.44 sec, r = -0.38 +/- 0.18 for CC [aBP --> FV(MCA)]. Comparison between the cross-correlation test results and the bedside tests showed a sensitivity of 44-73% for CC [aBP --> FV(MCA)], whereas CC [aBP --> ICP] was more specific (60-80%). Long-term monitoring revealed stable cross-correlation tests in about 45% of the measurement time. It is concluded that cross-correlation between aBP, ICP, and FV(MCA) is a valid means to monitor the autoregulation status continuously, although further improvement of sensitivity and specificity is needed to make it reliable for clinical decision making.

Adult↗

PubMed2002

Continuous cerebral autoregulation monitoring by cross-correlation analysis: evaluation in healthy volunteers.

OBJECTIVE: In a former study, we applied cross-correlation (CC) analysis to recordings of arterial blood pressure (BP), intracranial pressure (ICP), and intracranial blood flow velocity (FV). A lack of significant time delay and a positive correlation coefficient of slow oscillations between these parameters was interpreted as indicative of impaired cerebral autoregulation, whereas a significant time delay and a negative correlation was regarded as preserved autoregulation. To test this hypothesis, cross-correlation was applied on recordings of BP and FV (CC [BP --> FV]) in healthy volunteers with a presumably preserved cerebral autoregulation. DESIGN: Study of a diagnostic test. SUBJECTS: A total of 17 healthy volunteers. MEASUREMENTS AND MAIN RESULTS: BP was recorded by using a tonometric device, and bilateral FV in the middle cerebral arteries (MCA) was measured by transcranial Doppler sonography. Signals were sampled at a resting horizontal position for 29 mins. Cluster analysis showed a mean +/- sd time delay for CC [BP --> FV(MCA right)] of 6.45 +/- 2.1 secs, and for CC [BP --> FV(MCA left) ] of 6.09 +/- 1.8 secs. The mean correlation coefficient was -.33 +/-.17 for the left and -.36 +/-.09 for the right side. In about 30%, differing results with a correlation coefficient between -.2 and.2 and a time delay near zero were found. Cross-correlation between left and right FV showed a mean time delay of 0.09 +/- 0.18 secs, with a mean correlation coefficient of.82 +/-.16. CONCLUSION Spontaneous slow oscillations of BP and FV were detected, and cross-correlation analysis showed a negative correlation and a positive time delay in about 70% of the examinations. These findings corroborate the hypothesis that CC [BP --> FV] might be able to assess the status of cerebral autoregulation continuously. The observed time delay between BP and FV oscillations is in good agreement with former studies on the dynamic properties of cerebral autoregulation.

Adult↗

PubMed2002

Co-registration of function and anatomy in frameless stereotaxy by contour fitting.

We investigated a co-registration algorithm using a contour-fitting procedure to integrate functional data from magnetoencephalography (MEG) and functional magnetic resonance imaging (fMRI) for frameless stereotaxy. In fMRI the shape of the head was reconstructed from anatomical images, in MEG it was scanned using an electromagnetic sensor position indicator. Functional information was transferred to the 3D-MR image set used for frameless stereotaxy by fitting the digitized (MEG) and reconstructed head shape (fMRI) to the 3D-MR images. The mean residual error of the contour fit was 2.3 mm for the MEG and 1.3 mm for the fMRI registration. According to computer simulations, the achievable transformation error is 0.75 and 0.5 mm, respectively. This method enables independent recording of functional and anatomical measurements with a co-registration accuracy better than 2 mm.

Brain↗

PubMed2002

Problems in differential diagnosis of non Langerhans cell histiocytosis with pituitary involvement: case report and review of literature.

Differentiation among various non Langerhans cell histiocytoses granulomatous in adults is often difficult. Patients, moreover, may not have endocrinologic abnormalities. A 53-yr-old patient was admitted owing to central diabetes insipidus and partial hypopituitarism. Magnetic resonance imaging revealed a space-occupying lesion near the hypophyseal stalk, along with diffuse signal uptake in the cerebellar region. Laboratory chemistry showed monoclonal gammopathy of IgGkappa, and hormone tests disclosed insufficiency in the gonadotropic and somatotropic axes. The clinical picture was marked by multiple cutaneous xanthogranulomas, ataxic gait with blurred speech, compatible with pseudobulbar pontocerebellar symptomatology. Stereotactic pituitary biopsy was histologically classified as nonspecific granulomatous disease. Supplemental biopsies taken from the cutaneous periorbital xanthogranulomas were histologically and immunohistochemically consistent with non Langerhans cell histiocytosis. Systemic cortisone treatment as well as local radiotherapy to the pituitary lesion with a total of 18.0 gy had no impact on the progression of disease-growing tumor and progressing neurologic symptoms. Systemic granulomatoses cannot always be classified according to specific defined diseases. Differential diagnosis in the current patient should include the possibility of Erdheim-Chester disease, necrobiotic xanthogranuloma, and adult disseminated xanthoma.

Biopsy↗