Biomedical subjects

Rolf F Schulte

Publications and source records attributed to Rolf F Schulte.

5 recordsLinked to original sources

PubMed2006

Prostate spectroscopy at 3 Tesla using two-dimensional S-PRESS.

Two-dimensional (2D) strong-coupling point-resolved spectroscopy (S-PRESS) is introduced as a novel approach to (1)H MR spectroscopy (MRS) in the prostate. The technique provides full spectral information and allows for an accurate characterization of the citrate (Cit) signal. The method is based on acquiring a series of PRESS spectra with constant total echo time (TE). The indirect dimension is encoded by varying the relative lengths of the first and second TEs (TE(1) + TE(2) = TE). In the resulting 2D spectra, only the signal of strongly coupled spin systems is spread into the second dimension, which leads to more clearly arranged spectra. Furthermore, the spectral parameters of Cit (coupling constant J and chemical shift difference delta of the AB spin system) can be determined with high accuracy in vivo. The sequence is analytically optimized for maximal "strong coupling peaks" of Cit at 3T. 2D S-PRESS spectra are compared with JPRESS spectra in vitro as well as in vivo.

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PubMed2006

ProFit: two-dimensional prior-knowledge fitting of J-resolved spectra.

A two-dimensional fitting procedure is introduced, capable of extracting the full amount of information from 2D J-resolved magnetic resonance spectroscopic data. The fitting procedure uses a linear combination of 2D model spectra. For reducing the degrees of freedom and increasing robustness, it is divided into a non-linear outer loop and an inner linear least-squares fit for the concentrations. In vitro and in vivo experiments on a whole-body 3 T MR scanner show the detectability of a wide range of metabolites in the human brain, namely total creatine, N-acetylaspartate, N-acetylaspartylglutamate, choline-containing compounds, glutamate, myo-inositol, glutathione, scyllo-inositol, gamma-aminobutyric acid, alanine and ascorbic acid.

Adult↗

PubMed2006

Improved two-dimensional J-resolved spectroscopy.

Localised two-dimensional J-resolved spectroscopy (JPRESS) is optimised for the in vivo detection of J-coupled metabolites using magnetic resonance spectroscopy at 3 T. The acquisition of echo signals starts as early as possible (i.e. maximum-echo sampling). This sampling scheme increases sensitivity and decreases overlap of peak tails, hence alleviating baseline problems. Reconstruction issues are discussed and the sensitivity is compared analytically with that of 1D PRESS. The qualitative behaviour of eddy currents in JPRESS is outlined and a 2D eddy current correction procedure based on the 1D phase deconvolution method is proposed.

Adult↗

PubMed2005

Chemical-shift-selective filter for the in vivo detection of J-coupled metabolites at 3T.

A chemical-shift-selective filter (CSSF) was applied to the detection of J-coupled metabolites in the human brain. This filter is an acquisition-based technique that requires the chemical shifts (CS's) of different metabolites, but not their whole multiplet structures, to be resolved. The sequence is based on the 2D constant-time spin-echo experiment, which yields pure CS spectra in the indirect dimension. Localization is achieved through point-resolved spectroscopy (PRESS). The method enables unequivocal detection of glutamate and myo-inositol, both in vitro and in vivo in the human brain, at 3T.

Adult↗

PubMed2004

Equi-ripple design of quadratic-phase RF pulses.

An improved strategy for the design of quadratic-phase RF pulses with high selectivity and broad bandwidths using the Shinnar-Le Roux (SLR) transformation is proposed. Unlike previous implementations, the required quadratic-phase finite impulse response (FIR) filters are generated using the complex Remez exchange algorithm, which ensures an equi-ripple deviation from the ideal response function. It is argued analytically that quadratic-phase pulses are near-optimal in terms of minimising the B1-amplitude for a given bandwidth and flip angle. Furthermore, several parameter relations are derived, providing practical design guidelines. The effectiveness of the proposed design method is demonstrated by examples of excitation and saturation pulses applied in vitro and in vivo.

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