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Biomedical subjects

Roland Kassab

Publications and source records attributed to Roland Kassab.

10 recordsLinked to original sources
PubMed2006

Effects of clopidogrel on soluble CD40 ligand and on high-sensitivity C-reactive protein in patients with stable coronary artery disease.

BACKGROUND: Antiplatelet therapy with clopidogrel decreases ischemic complication especially in patients with acute coronary syndromes or after percutaneous coronary interventions. Our study was designed to test the effects of clopidogrel on soluble CD40 ligand (sCD40l) and on high-sensitivity C-reactive protein (hs-CRP) in patients with stable coronary artery disease (CAD). METHODS: This is a randomized, double-blind, placebo-controlled study. A total of 73 patients with stable CAD for > 6 months were randomized to receive either clopidogrel (loading dose 300 mg followed by 75 mg/d) for 8 weeks or placebo. Soluble CD40 ligand and hs-CRP were measured at baseline and at completion of the study. RESULTS: All patients were on aspirin therapy, and 74% were on statins. Median and interquartile ranges (IQR) of sCD40l decreased from 64 pg/mL (43-99) at baseline to 53 pg/mL (35-77) at 8 weeks (P = .03) in the clopidogrel group and remained unchanged in the placebo group (59 pg/mL, IQR 35-77 vs 55 pg/mL, IQR 35-78) (P = non significant). Levels of hs-CRP were not affected by therapy and remained unchanged in both groups. CONCLUSIONS: In patients with stable CAD, clopidogrel inhibits the release of sCD40l by platelets, which may contribute to the clinical benefit provided by this drug. This, however, does not translate in a reduction of subclinical inflammation, as measured by hs-CRP.

Aged↗
PubMed2006

Percutaneous coronary intervention increases leptin and decreases adiponectin levels.

OBJECTIVE: The study was designed to examine the effect of percutaneous coronary intervention (PCI) on adiponectin and leptin levels. We have previously demonstrated that PCI triggers a systemic inflammatory response. We hypothesized that inflammation participates in the pathogenesis of diabetes mellitus and the metabolic syndrome by modulating levels of adiponectin and leptin. DESIGN: Prospective study in which inflammation was induced by PCI. PATIENTS: Forty-eight patients with stable coronary artery disease and without diabetes mellitus. MEASUREMENTS: High-sensitivity C-reactive protein (hs-CRP), interleukin-6 (IL-6), leptin and adiponectin were measured at baseline and 48 h after the procedure. RESULTS: Following PCI, hs-CRP increased by 211%, IL-6 by 87% and leptin by 19%, while adiponectin decreased by 14% (P < 0.001 for all). The change in IL-6 correlated with that in hs-CRP (rho = 0.32; P = 0.027), as did the changes in IL-6 and leptin (rho = 0.31; P = 0.03). The change in adiponectin, however, did not correlate with the change in any of the other markers. CONCLUSION: This study demonstrates that PCI affects the levels of adiponectin and leptin within 48 h. These effects may be secondary to the inflammatory response triggered by PCI.

Adiponectin↗
PubMed2005

Effects of tirofiban and statins on high-sensitivity C-reactive protein, interleukin-6, and soluble CD40 ligand following percutaneous coronary interventions in patients with stable coronary artery disease.

This study assessed the effects of tirofiban and statins on high-sensitivity C-reactive protein, interleukin-6, and soluble CD40 ligand after percutaneous coronary intervention in patients who had stable coronary artery disease. Tirofiban insignificantly limited the increase of soluble CD40 ligand after revascularization, especially in patients who had high levels of this marker at baseline (p = 0.06), whereas statins significantly inhibited increases in interleukin-6 and, to a lesser extent, high-sensitivity C-reactive protein without affecting the soluble CD40 ligand.

Angioplasty, Balloon, Coronary↗
PubMed2003

T wave pacing inducing electrical storm and multiple shocks in an ICD-recipient: a novel complication of the automatic gain control function.

Implantable cardioverter-defibrillator (ICD) is highly effective in treating life-threatening ventricular arrhythmias, but it can also have proarrhythmic effect in some cases. We report the case of a 72 years old patient with an ischemic cardiomyopathy in whom an ICD was implanted for a poorly tolerated ventricular tachycardia (Profiles MD-Ventritex). Forty-eight hours after implantation, the patient suddenly received 15 successive shocks. ECG tracings and intracardiac EGM showed the presence of several VT episodes, all induced by the antibradycardia pacing of the ICD: the automatic gain control function of the device failed to detect ventricular premature beats in this patient, leading to a bradycardia pacing falling on the T wave and inducing multiple VTs and shocks.

Aged↗
PubMedDate not supplied

[Management of acute transmural myocardial infarction: a study on 200 patients admitted to a tertiary care medical center].

OBJECTIVE: To verify if the management of acute transmural myocardial infarction in a university hospital, follows the international guidelines of the ACC/AHA. DESIGN: This is a retrospective study on 200 consecutive patients admitted with an acute transmural myocardial infarction. Data were obtained by review of medical records. RESULTS: 20.5% of patients were treated with primary angioplasty, 44% received thrombolytic therapy and 35.5% a conventional medical treatment. Mean age was 62 +/- 11.64 years and 72% of the patients were males. Risk factors were: smoking 62%, hyperlipidemia 46%, hypertension 43.5%, diabetes 33.5%, obesity 13.5%, and a family history of coronary artery disease 25%. 17.5% of patients had a prior history of myocardial infarction and 4.5% had prior coronary artery bypass graft surgery. The mean delay between onset of symptoms and arrival to the hospital was 12 hours. Chest pain was the main symptom and was present in 88% of patients. Cardiac arrest was observed in 7% of patients upon arrival to the emergency department. Administration of thrombolytic therapy followed the established criteria in all cases. Angioplasty was mainly performed in cases of cardiogenic shock, and as a rescue for failed thrombolytic therapy and for pain recurrence. The two reperfusion modalities were given equally to elderly patients, patients with prior coronary artery bypass surgery and to those with anterior wall myocardial infarction. Coronary angiography was done in 94% of patients, coronary angioplasty was subsequently performed on 30.1%, and bypass surgery on 27%. Mortality rate was 11.2%, and it was significantly higher in patients treated conventionally by comparison with thrombolysis and/or PTCA. Major arrhythmias were observed in 13.5% of cases and infections in 3.5%. Mean length of stay was 2.85 +/- 3.1 days in the intensive care unit and 8.9 +/- 6.7 days in the hospital. Treatment on discharge followed the international recommendations; aspirin was given to 87.5% of patients, beta-blockers to 63.3%, ACE inhibitors to 59% and statines to 32%. CONCLUSION: The management of acute transmural myocardial infarction at our institution follows the international guidelines. However, the delay between the onset of symptoms and arrival to the hospital needs to be shortened. Public awareness campaigns should be useful for that purpose. In addition, the treatment on discharge should be improved.

Acute Disease↗
PubMedDate not supplied

[Coronary angioplasty for primary cardiogenic shock following acute myocardial infarction].

BACKGROUND: In the setting of acute myocardial infarction (AMI), several investigators have demonstrated that emergency coronary angioplasty (PTCA) reduces in-hospital mortality of primary cardiogenic shock (CS) from 90% to less than 50% ; however, few studies have focused on the current outcome of non selected patients in whom the onset of AMI is immediately complicated by CS. PURPOSE OF THE STUDY: To evaluate in-hospital mortality of the patients admitted to our institution for Q wave AMI presented in CS. MATERIAL AND METHOD: Between 05/93 and 05/03, 30 consecutive pts, 26 men and 4 women, in CS following AMI were treated with direct PTCA, 26 without thrombolysis and 4 as rescue after failed streptokinase. AMI was defined by prolonged chest pain and > or =1 mm ST segment elevation in > or =2 contiguous peripheral leads or > or =2 mm for precordial leads on the admission ECG. The diagnosis of CS was based on the combination of systolic blood pressure of <90 mm Hg, unresponsive to volume expansion, signs of acute circulatory failure (cyanosis, cold extremities, restlessness, mental confusion or coma) and congestive heart failure secondary to myocardial dysfunction. In 40% of cases the diagnosis of CS was only clinical and in 60% of cases was confirmed by a Swan Ganz catheter. Mean age was 62.3 +/- 12.3 years, 7 had triple vessel disease, 14 a double vessel disease, 8 a single vessel disease and in one case a left main disease. The AMI was anterior in 22 pts (73%), inferior in 8 (27%). Intraaortic balloon was used in 3 pts, CPR in 16 (47%), transitory pacemaker in 1 pt, inotropes in 25 pts, emergency coronary artery bypass grafting (CABG) in 1 pt. RESULTS: Success for PTCA with a residual stenosis < 50% and a TIMI flow III was obtained in 26 pts (87%). Mean time between CS and revascularization was 219 +/- 302 minutes. 19 pts (63%) survived and 11 pts (37%) died while at the hospital, 6 from intractable shock, 4 from multiple organ failure and in 1 case from pulmonary hemorrhage. Mean time of revascularization for the surviving was 190 +/- 329 min, and for the dead 295 +/- 212 min. Hospital mortality for inferior infarction is 12.5% after successful angioplasty. Comparison of surviving and non surviving number of patients according to revascularization time showed a significant difference of these groups whether the revascularization was accomplished before or after 120 minutes. [table: see text] CONCLUSION: Direct PTCA for AMI immediately complicated by CS, can be achieved with a high success rate, and can significantly reduce in-hospital mortality; this improvement of survival is most evident if revascularizarion is performed early.

Acute Disease↗
PubMedDate not supplied

[Control of blood pressure morning surge in a Lebanese hypertensive population].

OBJECTIVE: The primary endpoint of this prospective clinical study is to ascertain the degree of blood pressure control in the early-morning hours after 8 weeks of treatment with Telmisartan in hypertensive patients using home blood pressure measurements. METHODS: Two hundred forty Lebanese patients with uncontrolled hypertension are enrolled in the study. The blood pressure is measured at the initial visit, then at week 4 of follow-up (optional visit) and after the 8 weeks period, by the physician at his office (with pulse rate) and by the patient at home in the morning. RESULTS: The blood pressure measured by the patient at home in the morning has a mean value of 129.7/79.1 mmHg, significantly less than 135/85 mmHg (P < 10(-1)), and it is reduced by 31.9/13.5 mmHg (P < 10(-5)). At the physician's office, the reduction is 34.8/16 mmHg (P < 10(-4)). Heart rate is decreased by 4.7+/-0.5 bpm (P < 10(-5)). The drug was well tolerated. CONCLUSION: This study has demonstrated that Telmisartan, by his long half-life, protects the patients against the early-morning hours blood pressure surge, period during which coronary and cerebral events are the most frequent.

Angiotensin II Type 1 Receptor Blockers↗