Toward improved adverse event/suspected adverse drug reaction reporting.
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Biomedical subjects
Publications and source records attributed to Robert Gross.
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This paper provides an overview of some of the key technological and market developments for leading renewable energy technologies--wind, wave and tidal, photovoltaics (PV) and biomass energy. Market growth, innovation and policy are closely interrelated in the development of renewables and the key issues in each area are explored for each of the main types of renewable energy technology. This enables the prospects for future development and cost reduction to be considered in detail. Key issues for policy are outlined.
We studied the ability of providers to predict and estimate patient adherence to newly initiated highly active antiretroviral therapy (HAART). Nineteen providers referring 40 patients into an adherence study were surveyed. Widespread inaccuracy was found in providers' adherence predictions and estimates. Therefore, HAART should not be withheld solely on provider predictions of adherence. Providers should not rely on their own assessments when attempting to determine if patients are adhering to therapy.
The influence of isosorbide mononitrate on skin blood flow in the pulp of finger by means of laser-Doppler flowmetry was evaluated in 19 women with Raynaud's syndrome. Skin blood flow changes were measured after cooling the hand. Isosorbide mononitrate decreased the influence of cooling on skin blood flow in the pulp of finger. This finding supports the theory that endothelial dysfunction is one of the reasons of Raynaud's syndrome. We suppose that application of isosorbide mononitrate should be useful in prevention and the treatment of Raynaud's phenomenon attacks.
Antiretroviral therapy has dramatically improved the prognosis for many patients with HIV infection. For many patients who can navigate combinations of drugs and time their doses precisely, these drug regimens typically slow the progression of the disease and lengthen survival. But because these drug regimens are very complex, adherence--the degree to which patients follow medical advice in taking the prescribed drugs--is now a major determinant of HIV treatment success. This Issue Brief summarizes recent work on the effect of adherence on short-term outcomes, and the ability of providers to predict and estimate their patients' adherence to therapy.
PURPOSE: To determine (1) the rate of prenatal hepatitis B virus (HBV) vaccine acceptance in HBV nonimmune pregnant adolescents, (2) if postulated behavioral and attitudinal factors are associated with HBV vaccine, and (3) the rate of actual receipt of HBV vaccine postpartum in eligible subjects. DESIGN AND METHODS: During 1999-2000, at an inner-city tertiary-care center prenatal clinic, 160 HBV nonimmune adolescents <18 years who were receiving prenatal and delivery care at the center were identified. The research nurse provided an HBV information pamphlet and offered immediate in-hospital postpartum HBV vaccination. Risk factors for nonacceptance of the vaccine were measured with structured questionnaires and medical record review documenting care attendance. Subsequently, all subjects, irrespective of prenatal acceptance of vaccine, were offered vaccine before postpartum discharge, and the rate of actual acceptance was determined. RESULTS: In these predominantly African American (95%) adolescents, the rate of vaccine acceptance was 91%. Actual vaccination rate was 86%, but it was not associated with prior acceptance of vaccination or behavioral or attitudinal factors. CLINICAL IMPLICATIONS: Acceptance of vaccination and actual vaccination were high in this population of high-risk adolescents. The authors found that reoffering vaccine was a successful intervention, even with adolescents who had less-than-optimal attendance at prenatal visits. Given the high rate of acceptance and vaccination in this setting, the authors would encourage public health programs to implement vaccination programs in adolescent prenatal clinics and to offer vaccination postpartum to those who do not receive it prenatally.