Biomedical subjects

Richard S C Cobbold

Publications and source records attributed to Richard S C Cobbold.

10 recordsLinked to original sources

PubMed2007

A pioneer in the development of modern ultrasound: Robert William Boyle (1883-1955).

Robert William Boyle was one of the pioneers in the development and application of ultrasound. His remarkable career has not been previously traced in any depth, nor have his contributions, especially those during WWI, been carefully described. In collaboration with Lord Rutherford, his work on the development of ultrasound methods for submarine detection paralleled those in France under Paul Langevin (1872-1946), who many consider to be the father of modern ultrasound. This biographic account of Boyle's life focuses on his ultrasound research contributions, particularly the developments during WWI and those in the 10 years after. Evidence is presented that his pioneering research, along with that of Langevin, provided much of the foundation for modern ultrasound developments. Although this paper is partially based on somewhat dispersed biographic information performed by others, original letters and research papers, in addition to records and verbal accounts provided by relatives, have been used and consulted.

Canada↗

PubMed2006

Transit-time broadening in pulsed Doppler ultrasound: a generalized amplitude modulation model.

In Doppler ultrasound, transit-time broadening arises from the finite scatterer transit time through the sample volume. As a unifying description of this broadening mechanism, a generalized amplitude modulation signal model was developed to collectively account for the transit-time effects of the ultrasound beam geometry and the range gate characteristics. Simulations based on a pulsed linear-array system also were performed to study the broadening extent for different scatterer flow lines. With our signal model and simulation results, some generalized insights were obtained on the characteristics of transit-time broadening. First, as consistent with previous findings, we found that, for scatterers passing though the center of the sample volume, the broadening extent mainly depends on beam-forming characteristics at higher beam-flow angles, but it is more dependent on range gate parameters at smaller angles. Second, for the central flow line, a transition angle exists in which a significant change occurs in the governing parameters of transit-time broadening. Third, for the general case in which scatterers undertake an off-central path through the sample volume, the broadening extent depends on both the beam geometry and the range gate. Bandwidth skewing and further spectral broadening also can be seen for these off-central flow lines.

Arteries↗

PubMed2006

Recanalization of obstructed cerebrospinal fluid ventricular catheters using ultrasonic cavitation.

OBJECTIVE: Fifty percent of implanted cerebrospinal fluid (CSF) shunts fail within 2 years, primarily because of obstruction of the proximal catheter. Percutaneous techniques to reduce the morbidity of shunt revision are being developed. The authors describe the development of a device that uses ultrasonic cavitation to unblock ventricular catheters. METHODS: In collaboration with Cybersonics, Inc. (Erie, PA), we designed, built, and tested a system that produces low-frequency ultrasound (20-28 kHz). Extensional ultrasonic waves are transmitted along a tapered wire (final diameter, approximately 0.8 mm) to the tip, where cavitation is produced in a highly localized region. An in vitro model of sheep choroid plexus occluding typical ventricular catheters was developed. The device was safety tested in vivo in rat and pig brains by introducing the device into shunt catheters inserted during simulated shunt surgery. A clinical safety trial using the device to attempt to remove blocked and adherent ventricular catheters has commenced. RESULTS: In the sheep choroid plexus model, at least 90% of the occluded holes were unblocked in a few minutes, restoring normal flow. There was no adverse effect of the device within shunt catheters inserted into live animal brains. Four patients have undergone treatment with the device at open CSF shunt surgery without adverse effect, and the device seems effective at unblocking and freeing the occluded catheters. CONCLUSION: Ultrasonic cavitation produced at the end of a fine wire that is introduced percutaneously into a CSF shunt promises to be a useful technique for minimally invasive proximal ventricular CSF shunt catheter revision.

Animals↗

PubMed2005

Human factors as a source of error in peak Doppler velocity measurement.

OBJECTIVE: The study was conducted to assess the error and variability that results from human factors in Doppler peak velocity measurement. The positioning of the Doppler sample volume in the vessel, adjustment of the Doppler gain and angle, and choice of waveform display size were investigated. We hypothesized that even experienced vascular technologists in a laboratory accredited by the Intersocietal Commission for Accreditation of Vascular Laboratories make significant errors and have significant variability in the subjective adjustments made during measurements. METHODS: Problems of patient variability were avoided by having the four technologists measure peak velocities from an in vitro pulsatile flow model with unstenosed and 61% stenosed tubes. To evaluate inaccurate angle and sample volume positioning, a probe holder was used in some of the experiments to fix the Doppler angle at 60 degrees. The effect of Doppler gain was studied at three settings--low, ideal, and saturated gains--that were standardized from the ideal level chosen by consensus amongst the technologists. Two waveform display sizes were also investigated. Peak velocity measurement was assessed by comparison with true peak velocities. For each variable studied, average peak velocities were calculated from the 10 measurements made by each technologist and used to find the percent error from the true value, and the coefficient of variation was used to measure the variability. RESULTS: Doppler angle, sample volume placement, and the Doppler gain were the most significant sources of error and variability. Inaccurate angle and placement increased the variability in measurements from 1% to 2% (range) to 4% to 6% for the straight tube and from 1% to 2% to 3% to 9% for the 61% stenosis. The peak velocity error was increased from 9% to 13% to 7% to 28% for the stenosis. Both measurement error and variability were strongly dependent on the Doppler gain level. At low gain, the error was approximately 10% less than the true value and at saturated gain, 20% greater. The display size only affected measurements from the stenosed tube, increasing the error from 9% to 13% to 15% to 24%. CONCLUSIONS: Major factors affecting Doppler peak velocity measurement error and variability were identified. Inaccurate angle and sample volume placement increased the variability. The presence of a stenosis was found to increase the measurement errors. The error was found to depend on the Doppler gain setting, with greater variability at low and saturated gains and on the display size with a stenosis. CLINICAL RELEVANCE: Doppler ultrasound peak velocity measurements are widely used for the diagnostic assessment of the severity of arterial stenoses. However, it is known that these measurements are often in error. We have identified subjective human factors introduced by the technologist and assessed their contribution to peak velocity measurement error and variability. It is to be hoped that by understanding this, improvements in the machine design and measurement methods can be made that will result in improved measurement accuracy and reproducibility.

Artifacts↗

PubMed2005

Effects of beam steering in pulsed-wave ultrasound velocity estimation.

Experimental and computer simulation methods have been used to investigate the significance of beam steering as a potential source of error in pulsed-wave flow velocity estimation. By simulating a typical linear-array transducer system as used for spectral flow estimation, it is shown that beam steering can cause an angle offset resulting in a change in the effective beam-flow angle. This offset primarily depends on the F-number and the nominal steering angle. For example, at an F-number of 3 and a beam-flow angle of 70 degrees , the velocity error changed from -5% to + 5% when the steering angle changed from -20 degrees to + 20 degrees . Much higher errors can occur at higher beam-flow angles, with smaller F-numbers and greater steering. Our experimental study used a clinical ultrasound system, a tissue-mimicking phantom and a pulsatile waveform to determine peak flow velocity errors for various steering and beam-flow angles. These errors were found to be consistent with our simulation results.

Blood Flow Velocity↗

PubMed2004

Sample volume shape for pulsed-flow velocity estimation using a linear array.

Various definitions of the sample volume (SV) shape have been proposed, but they are mostly based on transducers with axisymmetrical geometry. We have defined the SV as that spatial region in which scatterers contribute a component to the total gated received-signal energy above a defined threshold. This definition is consistent with modern pulsed transducer arrays and accounts for the need to impose a signal/noise threshold. Based on this definition, SVs for a typical linear phased-array transducer were simulated using custom-designed software. The effects of different transmit pulses, receive gates, apertures, SV depths and lateral foci were studied using a one-dimensional (1-D) beam-forming array, with a fixed lens in the elevation direction. Based on a simplified method of analysis, the features of the beam-steered SV are qualitatively similar to those of the nonsteered SV, when compared at the same beam-flow angle. These studies have helped provide a clearer understanding of the manner in which the SV energy distribution is affected by various parameters. The results can have potentially significant implications in the use of ultrasound (US) for blood velocity estimation, specifically with respect to locating the SV within the blood vessel and the origin of the velocity spectrum.

Computer Simulation↗

PubMed2004

Frequency-domain wave equation and its time-domain solutions in attenuating media.

Our purpose in this paper is to describe the wave propagation in media whose attenuation obeys a frequency power law. To achieve this, a frequency-domain wave equation was developed using previously derived causal dispersion relations. An inverse space and time Fourier transform of the solution to this algebraic equation results in a time-domain solution. It is shown that this solution satisfies the convolutional time-domain wave equation proposed by Szabo [J. Acoust. Soc. Am. 96, 491-500 (1994)]. The form of the convolutional loss operator contained in this wave equation is obtained. Solutions representing the propagation of both plane sinusoidal and transient waves propagating in media with specific power law attenuation coefficients are investigated as special cases of our solution. Using our solution, comparisons are made for transient one-dimensional propagation in a medium whose attenuation is proportional to frequency with recently obtained numerical solutions of Szabo's equation. These show good agreement.

Acoustics↗

PubMed2004

Transient propagation in media with classical or power-law loss.

This paper addresses the problem of small-signal transient wave propagation in media whose absorption coefficient obeys power-law frequency dependence, i.e., alpha infinity omega n. Our approach makes use of previously derived relations between the absorption and dispersion based on the Kramers-Kronig relations. This, combined with a recently obtained solution to a causal convolution wave equation enable expressions to be obtained for one-dimensional transient propagation when n is in the range 0 < n < 3. For n = 2, corresponding to no dispersion, straightforward analytical expressions are obtained for a delta-function and a sinusoidal step function sources and these are shown to correspond to relations previously derived. For other values of n, the effects of dispersion are accounted for by using Fourier transforms. Examples are used to illustrate the results for normal and anomalous dispersive media and to examine the question as to the conditions under which the effects of dispersion should be accounted for, especially for wideband ultrasound pulses of the type used in B-mode tissue imaging. It is shown that the product of the attenuation and total propagation path can be used as a criterion for judging whether dispersion needs to be accounted for.

Journal Article↗

PubMed2003

Modeling of nonlinear ultrasound propagation in tissue from array transducers.

A computationally efficient model capable of simulating finite-amplitude ultrasound beam propagation in water and in tissue from phased linear arrays and other transducers of arbitrary quasiplanar geometry is described. It is based on a second-order operator splitting approach [Tavakkoli et al., J. Acoust. Soc. Am. 104, 2061-2072 (1998)], with a fractional step-marching scheme, whereby the effects of diffraction, attenuation, and nonlinearity can be computed independently over incremental steps. This approach is an extension to that of Christopher and Parker [J. Acoust. Soc. Am. 90, 507-521; 90, 488-499 (1991)], wherein linear and nonlinear effects are propagated separately over incremental steps, and the computation of the diffractive substeps are based on an angular spectrum technique with a modified sampling scheme for accurate and efficient implementation of diffractive propagation from nonradially symmetric sources. Results of the model are compared with published data. Predicted field profiles for nonlinear propagation in tissue from realistic array transducers using the pulse inversion method are presented.

Algorithms↗

PubMed2002

Propagation of limited-diffraction X-waves in dissipative media.

Diffractionless solutions of the wave equation in the form of X-waves have previously been obtained based on the inviscid form of the wave equation. A new general solution to the cylindrically symmetric wave equation for a medium with classical viscous losses is obtained. Particular solutions called dissipative Arcsin X-waves have been derived from this general solution. The properties of these waves are discussed for both infinite and finite size transducers and for different viscous liquids. To calculate the field produced by a finite transducer diameter, we have derived a dissipative form of the Rayleigh integral.

Journal Article↗