Professor Moshe Wolman: pioneer in histochemistry.
Explore the source record for details and available documents.
Histocytochemistry↗
Biomedical subjects
Raymond Coleman
Publications and source records attributed to Raymond Coleman.
Effects of a treadmill walking program on muscle strength and balance in elderly people with Down syndrome.
BACKGROUND: Longer life expectancy is resulting in increasing numbers of elderly adults with mental retardation. In elderly adults with Down syndrome (DS), the maintenance of muscle strength, endurance, and dynamic balance are important to ensure quality of life and functional independence. The objective of this study was to compare isokinetic leg strength and dynamic balance of aged mentally retarded individuals with DS (n = 16, mean age 63) before and after a treadmill walking program lasting 6 months in comparison with a nonwalking control group (n = 10) with similar physical characteristics. METHODS: Participants in the study undertook leg strength testing on a dynamometer. Parameters measured included peak torque, peak torque % body weight, and average power % body weight. A "timed get-up and go" functional test for dynamic balance was also analyzed and compared prior to and after the treadmill program. RESULTS: Knee extension and flexion isokinetic strength in elderly individuals with DS showed significant improvement after 6 months of treadmill training. Dynamic balance performance was also significantly improved (p <.05). CONCLUSIONS: Aged adults with DS can significantly improve muscle strength and balance by adopting suitable programs of treadmill walking.
Aged↗
Activities of antioxidant scavenger enzymes (superoxide dismutase and glutathione peroxidase) in erythrocytes in adult women with and without type II diabetes.
It is widely believed that oxidative stress plays an important role in the pathogenesis of type II diabetes. The present study was undertaken to examine the functioning of two antioxidant scavenger enzymes, superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px), in erythrocytes in a population of healthy aging adult women compared with a similar population with type II diabetes. Blood samples were examined from 42 female adult healthy subjects at different ages and from 59 female patients with type II diabetes. A significant increase in SOD activities was correlated with aging in erythrocytes of the healthy control subjects (r =.550, P =.001); however, this correlation was not found in subjects with type II diabetes (r =.250, P <.07). A trend showing a reduction in glutathione peroxidase activities was demonstrated with aging (r = -.331, P =.228); however, this trend was not found in diabetic subjects (r =.031, P <.820). The results indicate a possible imbalance in the antioxidant system in erythrocytes of aging adult women, which is even more pronounced in cases of type II diabetes. This study may indicate possible therapeutic treatment or preventive measures to limit oxidative damage and reduce complications of diabetes.
Aging↗