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Biomedical subjects

Randall J Olson

Publications and source records attributed to Randall J Olson.

41 records · Page 3Linked to original sources

Microphacoemulsification with WhiteStar. A wound-temperature study.

PURPOSE: To verify the temperature-induction effect of bimanual ultrasound-based phacoemulsification through 2 stab incisions with a bare aspiration needle and new proprietary technology. SETTING: In vitro laboratory. METHODS: The Sovereign phacoemulsification unit and the WhiteStar system (Allergan) were used in conjunction with the Olson irrigating chopper (ASICO) and a 19-gauge bare phaco needle in 2 human cadaver eye-bank eyes at 100% power unoccluded, 100% power with aspiration completely occluded, and 100% power with aspiration and flow completely occluded. Temperature data were monitored throughout the experiment. Any sign of a wound burn, defined as temperature exceeding 45 degrees C, whitening around the wound, or wound contraction, was the end point. RESULTS: At 100% continuous phacoemulsification power, the temperature did not rise above 27.3 degrees C. When the aspiration line was totally occluded at 100% continuous power, the temperature did not rise above 32.5 degrees C. When flow into the eye and aspiration were completely occluded at 100% power, a wound change and temperature of 45 degrees C occurred in 45 seconds in the first eye and in 29 seconds in the second eye. CONCLUSIONS: Using the Sovereign phacoemulsification unit with the WhiteStar system during 2-stab-incision bimanual microphacoemulsification with a bare 19-gauge aspiration needle in human cadaver eyes, a wound burn could not be produced at the highest energy settings unless all flow into the eye and all aspiration were occluded. These settings were well beyond clinically applicable conditions and provide evidence that microphacoemulsification can be performed safely with the WhiteStar system.

Anterior Eye Segment↗

Bimanual phacoemulsification through 2 stab incisions. A wound-temperature study.

PURPOSE: To determine the thermal parameters of bimanual ultrasound-based phacoemulsification through 2 stab incisions with a bare aspiration needle. SETTING: In vitro laboratory. METHODS: The Sovereign phacoemulsification unit (Allergan) was used in 3 modes in conjunction with the Olson irrigating chopper (ASICO) in 6 fresh human cadaver eye-bank eyes to determine the temperature at which a wound burn would occur. A wound burn was defined as temperature exceeding 45 degrees C, whitening around the wound, or wound contraction. RESULTS: One hundred percent ultrasound power was required to create a wound burn in the unoccluded mode in continuous ultrasound and the burst mode. The time to create the wound burn was 160 and 180 seconds in 2 eyes in continuous ultrasound and 42 and 50 seconds in 2 eyes in the burst mode; it was 58 and 70 seconds in continuous ultrasound with complete occlusion and required 80% power. CONCLUSIONS: The energy necessary to obtain a wound burn during 2-incision bimanual ultrasound-based phacoemulsification with a bare aspiration needle in human cadaver eyes was extremely high. The parameters necessary to create a wound burn in each modality occurred well beyond normal clinical settings and provide evidence that 2-stab ultrasound-based lens extraction can be performed safely with the Sovereign machine.

Anterior Eye Segment↗

Three-year clinical comparison of 3-piece AcrySof and SI-40 silicone intraocular lenses.

PURPOSE: To compare the 3-year performance of the 3-piece AcrySof (Alcon) and the SI-40 silicone (Allergan) intraocular lenses (IOLs). SETTING: John A. Moran Eye Center, University of Utah, Salt Lake City, Utah, USA. METHODS: In this retrospective study, patients with no complications and at least a 3-year follow-up after IOL implantation were examined for signs of inflammation, visual function, posterior capsule opacification (PCO), and satisfaction. RESULTS: One hundred eleven patients were enrolled with equivalent visual acuity, inflammation, and PCO parameters. The AcrySof eyes had less anterior capsule opacification and more intralenticular inclusions than the other group. Complete anterior capsule overlap was associated with decreased PCO, and significantly more SI-40 eyes had complete anterior capsule overlap. CONCLUSIONS: The second-generation silicone IOL was equivalent to the 3-piece AcrySof in patient satisfaction, visual function, inflammation, and PCO. The amount of anterior capsule overlap on the IOL may help to explain the study differences.

Acrylic Resins↗

Survey of intraocular lens material and design.

Modern cataract surgery is constantly evolving and improving in terms of lens material and design. Researchers and physicians strive to obtain better refractive correction with smaller wound size and minimizing host cell response to limit the proliferation of lens epithelial cells leading to opacification of the lens capsule. Intraocular lens material varies in water content, refractive index, and tensile strength. Intraocular lens design has undergone revisions to prohibit lens epithelial cell migration and reflection of internal and external light. The evolution of intraocular lens and extracapsular cataract surgery has lead to faster postoperative recovery and better visual outcomes.

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