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Biomedical subjects

Ragip Ozkan

Publications and source records attributed to Ragip Ozkan.

9 recordsLinked to original sources

Peripheral intrapulmonary lipoma: a case report and review of the literature.

Lipomas are common benign tumours, but intrathoracic lipomas are rare and peripheral lung lipomas are exceptionally rare. Eight cases have been described in the world literature. We report a case of lipoma arising in the periphery of the left lower lung in a 54-year old woman. Grossly, it was presented as a well- circumscribed, thinly encapsulated, rounded, pale yellow mass. A wedge resection was done of the left lung and the microscopic findings revealed lipoma of the lung. The present paper recapitulates the macroscopic and microscopic features, the treatment and the differential diagnosis of this rare neoplasm.

Chest Pain↗

Cytomegalovirus-induced interstitial pneumonitis in a patient with dermatomyositis.

Dermatomyositis (DM) patients might present with pulmonary involvement as the first manifestation or during the follow-up period. It is sometimes difficult to determine whether the clinical manifestations related with pulmonary involvement are due to DM or to an infectious process. We report a case of DM patient who developed interstitial pneumonitis induced by cytomegalovirus (CMV) while receiving immunosuppressive treatment. To the best of our knowledge, this is the second report in the literature of interstitial pneumonitis secondary to CMV infection in a patient with DM.

Adult↗

[Recurrence rate after varicocelectomy in infertile men].

PURPOSE: To detect the recurrence rate of varicocele in infertile men with varicocelectomy. MATERIALS AND METHODS: Twenty of 94 infertile patients with varicocelectomy were examined by color Doppler ultrasonography. RESULTS: We found 60% recurrence of varicocele infertile men with varicocelectomy. The mean time after varicocelectomy was five years for the patients with recurrence, and seven years for patients without recurrence. CONCLUSION: Doppler sonography is a useful imaging modality in the examination of post-varicocelectomy infertile men without successful impregnation.

Adult↗

Relapsing polychondritis.

Relapsing polychondritis (RP) is a rare, inflammatory disease with multisystem involvement and it should be considered in the aetiology of sudden respiratory distress. A 49-year-old woman was admitted to the emergency service of Osmangazi Hospital in acute respiratory distress. She had a tracheostomy following a diagnosis of laryngeal stenosis 10 years earlier. She was managed thereafter at another hospital with a diagnosis of asthma. At admission she was in respiratory distress, had arthralgias, bilateral subconjunctival hyperaemia, periorbital oedema and skin lesions. A thoracic CT showed tracheal wall thickening. Calcification of the auricular regions were noted bilaterally. Bronchi, conjunctiva and skin lesions were biopsied with a provisional diagnosis of RP. The diagnosis of RP in this patient was based on clinical, pathological and radiological findings. Steroid therapy was begun and she was referred to a surgical centre for stenting. This case report emphasizes the need to consider the possibility of RP as a cause of sudden respiratory distress.

Female↗

[HRCT findings in congenital aural atresia].

PURPOSE: To define high resolution computed tomography findings in the external, middle and inner ear of patients with congenital aural atresia and to emphasize the importance of these findings in the preoperative evaluation. MATERIALS AND METHODS: Twenty one patients with congenital aural atresia (14 male, 7 female) aged between 1-30 years were evaluated with high resolution computed tomography of the temporal bone. A Toshiba TCT-600 scanner was used in 11 cases, and a Xvision/GX scanner was used in 10 cases. Sections 1 mm thick were obtained in axial and coronal projections using high bone detail algorithms. Sagittal reformations were also made when necessary. RESULTS: Forty-two ears in 21 patients with congenital aural atresia were studied. These included 8 patients with high bilateral and 13 with unilateral congenital aural atresia in which 8 patients had right sided and 5 patients had left sided atresia. Stenosis of the external auditory canal was found in 11 ears, complete atresia was found in 13 ears, incomplete atresia was found in 1 ear. There was varied ossicular deformity in 18 ears. Anomalies of the stapes and oval window were found in 6 ears. An anteriorly located mastoid segment of the facial nerve canal was identified in 11 ears. An inferiorly located tympanic segment of the facial nerve canal was identified in 2 ears, and 3 ears had an abnormal posterior orientation of the mandibular condyles. Only 2 patients had associated inner ear deformity. CONCLUSION: High resolution computed tomography is an effective method for the evaluation of the anomalies of the external, middle and inner ear in patients with congenital aural atresia and for planning the surgical treatment.

Adolescent↗

[Wegener granulomatosis: three cases].

Wegener granulomatosis (WG) is characterized by granulomatous vasculitis that involves multisystem, including upper and lower airways and kidney. WG may be a mortal disease if the diagnosis is delayed. The aim of this study is to present three patients admitted with different prediagnosis but after the investigations were diagnosed as WG and followed in our clinic. The cases were discussed with the literature knowledge. All three patients were diagnosed as WG with clinical, radiological and pathological findings. c-ANCA was positive in two patients, and negative one. Complete remission was established with treatment in one case. The treatment of other patients going on, however, the third patient was lost to follow up.

Adult↗

Computed tomography features in malignant pleural mesothelioma and other commonly seen pleural diseases.

OBJECTIVE: To investigate the computed tomography (CT) features of malignant pleural mesothelioma (MPM) cases, comparing them to those in other malignant and benign pleural diseases. MATERIALS AND METHODS: We reviewed the CT findings of 215 patients; 99 with MPM, 39 with metastatic pleural disease (MPD), and 77 with benign pleural disease. The findings were evaluated in univariate and multivariate analysis for differentiation of pleural diseases. RESULTS: In patients with MPM, the most common CT features were circumferential lung encasement by multiple nodules (28%); pleural thickening with irregular pleuropulmonary margins (26%); and pleural thickening with superimposed nodules (20%). In the majority (70%) of cases, there was rind-like extension of tumor on the pleural surfaces. In multivariate analysis, the CT findings of "rind-like pleural involvement", "mediastinal pleural involvement", and "pleural thickness more than 1 cm" were independent findings in differentiating MPM from MPD with the sensitivity/specificity values of 70/85, 85/67, and 59/82, respectively. "Rind-like pleural involvement", "mediastinal pleural involvement", "pleural nodularity" and "pleural thickness more than 1 cm" were independent findings for differentiation of malignant pleural diseases (MPM+MPD) from benign pleural disease with the sensitivity/specificity values of 54/95, 70/83, 38/96, and 47/64, respectively. Invasion of thoracic structures such as pericardium, chest wall, diaphragm, mediastinum, with pleural disease and nodular involvement of fissures, was detected infrequently; however, since these invasions were not seen in benign pleural diseases, it was concluded these invasions, if detected on a CT scan, directly suggested malignancy. CONCLUSION: A patient has extremely high probability of malignant pleural disease if one or more of these CT findings are found and the possibility of MPM is high. These findings may be important for patients in bad state or patients who do not want any invasive biopsy procedures. It is also possible to identify cases with a low probability of malignant disease.

Asbestosis↗

High-resolution computed tomography findings are correlated with disease severity in asthma.

BACKGROUND: The structural changes in the airways of asthmatics are also referred to as remodeling and can be identified using high-resolution computerized tomography (HRCT). OBJECTIVES: To find out whether there are any abnormal HRCT features which can be attributed to asthma and their clinical correlates, and any differences of abnormal HRCT features between asthmatics and patients with chronic obstructive pulmonary disease (COPD). METHODS: We performed (HRCT) scans to assess airway remodeling in 160 nonsmoker asthmatics compared with 27 patients with COPD. RESULTS: Bronchial wall thickening, hyperlucency, centrilobular prominence, bronchiectasis, thick linear opacities and mucoid impaction were all correlated with disease severity in asthma. FEV(1) values were inversely correlated with bronchial wall thickening, hyperlucency, mucoid impaction, linear shadows, centrilobular prominence and bronchiectasis. In addition, thick linear opacities, mucoid impaction and bronchiectasis were more prominent in those patients with a long duration of asthma. Bronchial wall thickening, thick linear opacities, mucoid impaction, bronchiectasis and emphysema were more prominent in COPD patients compared with asthmatics. There was no difference with regard to age, mean values of FEV(1) and the duration of asthma between allergic and nonallergic asthmatics as well as abnormal HRCT findings. CONCLUSIONS: COPD patients have more prominent HRCT findings as compared with asthmatics. In the asthmatics, abnormal HRCT findings are more prominent with increased severity, decreased FEV(1) values and the duration of asthma. The remodelling of airways in allergic asthmatics did not differ from that in their nonallergic counterparts as determined by HRCT.

Adult↗