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R Zouari

Publications and source records attributed to R Zouari.

At least 37 records · Page 2Linked to original sources
PubMed1991

In-vitro effects of anti-sperm antibodies on human sperm movement.

The present study was designed to investigate whether autoantibodies to external domains of the sperm plasma membrane affect the movement of normal motile spermatozoa. Eight sera and 20 seminal plasma samples containing high levels of anti-sperm antibodies as well as antibodies eluted from the sperm fraction of 19 autoimmune ejaculates were incubated with donor's motile spermatozoa, obtained by swim-up migration in Tyrode's solution. Sperm movement was analysed using 1 s exposure microphotography when greater than 70% of the spermatozoa were coated with antibodies (after 30-90 min of incubation). At least 50 tracks of progressively motile spermatozoa were analysed in order to obtain the mean values of the amplitude of lateral head displacement (ALH) and the velocity of progression (VSL). Serum antibodies and sperm eluted antibodies had quite consistent but opposite effects on sperm movement; serum antibodies increased ALH and decreased VSL whereas eluted antibodies decreased ALH and increased VSL. Seminal antibodies did not affect these two parameters significantly. Furthermore, seminal antibodies and sperm eluted antibodies obtained from the same ejaculates had distinct effects on ALH and/or VSL. This diversity was apparently not linked to antibody isotype or localization on the sperm membrane; it might be due to differences in the composition of the extracellular media. These results suggest a dynamic effect of anti-sperm antibodies on sperm movement, a possibility that merits further investigation.

Autoantibodies↗
PubMed1990

[Monoclonal gammopathies in Tunisia].

Protein electrophoresis and immunoelectrophoresis carried out on 4805 sera and 93 urine samples from Tunisian patients over 8 years, and a monoclonal protein was detected in 198 cases. The distribution of the monoclonal compounds to the clinical diagnosis was studied. 115 (58%) were classified as multiple myeloma (MK), 34 (17%) as alpha heavy chain disease (MCL a), 34 (17%) as monoclonal gammapathy associated to various diseases (GMOD), 11 (6%) as benign essential monoclonal gammapathies (GMBE), 4 (2%) as Waldenström's macroglobulinemia (MW). The relationship between the monoclonal immunoglobulin and the clinical diagnosis, the distribution of the monoclonal compounds according to the heavy chain class and the identification of the light chains were studied. The results obtained are in line with the principal data in literature concerning monoclonal gammapathy. However there is a particularity about monoclonal gammapathy observed in the Tunisian's population studied: Higher percentage of alpha heavy chain diseases, monoclonal IgD and monoclonal light chain. Lower percentage of monoclonal IgM in GMBE or GMOD, as in MW.

Aged↗
PubMedDate not supplied

[Destructive polyarthritis in Behcet's disease. Apropos of a case and review of the literature].

The authors report a case of a 37 years old man with Behçet's disease since 7 years who develops a destructive chronic polyarthritis involving wrists, hands and one knee. The parallel evolution between recurrent orogenital ulceration and arthritis added to the absence of other associated destructive rheumatism permit to link this polyarthritis to Behçet disease. In spite of the few reports, the occurrence of destructive arthritis can't exclude absolutely the diagnosis of this affection.

Adult↗
PubMedDate not supplied

[Rheumatic spondylodiscitis in spondylarthropathies].

The involvement of enthesis like disc space is the typical lesion of spondylarthropathies. Out of 240 patients with spondylarthropathies, 10 (7 M, 3 W; mean age: 37 years) have spondylodiscitis, affecting a total of 13 disc spaces: 1 cervical, 2 thoracic, 10 lumbar. The mean duration of spondylarthropathy at the time of diagnosis of spondylodiscitis is 10 years. Spondylodiscitis has a variable clinical presentation: painful (6 cases), asymptomatic (4 cases). Its coexistence with typical radiographic signs of spondylarthropathy added to the exclusion of bacterial origin, permit to link it to spondylarthropathy. Its evolution is generally favourable.

Adult↗