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Biomedical subjects

R Zimmerman

Publications and source records attributed to R Zimmerman.

At least 127 records · Page 7Linked to original sources
PubMed1976

Effect of cardiac arrest on cerebral circulation. An experimental investigation.

The effect of 2 to 15 min of cardiac arrest on cerebral circulation was investigated in dogs and Rhesus monkeys. When circulatory arrest lasted longer than 5 minutes, angiographic changes of the no-reflow phenomenon were observed between 3 and 4 h after resuscitation in dogs but not in monkeys. These findings were (1) marked prolongation of the arterial phase in both intracranial and extracranial arteries; followed by (2) occasional evidence of dilatation of the proximal intracranial arteries with non-filling of the distal intracranial arteries; and (3) faint demonstration of the venous phase. Carbon black perfusion results were (1) diffuse lack of perfusion at the arteriolar-capillary level and (2) multifocal areas of filling defects. Regional cortical blood flow measurement in monkeys disclosed a significant decrease in flow starting from 3 h after re-establishment of circulation for those in which longer than 5 min of arrest was induced.

Animals↗
PubMed1976

C.A.T. scans.

Explore the source record for details and available documents.

Humans↗
PubMed1975

Measurement of urinary CEA-like substance. An aid in management of patients with bladder carcinoma.

Urine and serum samples from patients with bladder carcinomas were studied for the occurrence of and variations in CEA content before, during, and after radiation therapy. The concentration of CEA-like substances in urine increased with a more advanced clinical stage of the tumor, although there were large intercase variations. In serum, slightly increased values were noted only in advanced cases. During radiation therapy, high CEA values were found at around mid-course. This could be related to a breakdown of tumor tissue. Judging from data for urine from radiation-treated prostatic carcinomas without known tumors in the bladder, radiation alone was not responsible for the elevation of CEA. Urinary infections contributed to raised levels of CEA-like substances in some cases. At the end of successful radiation therapy (as verified by cystoscopy, cytology, and clinical examination), 25 patients had CEA values in the urine comparable to normal values (14 +/- 7 ng CEA/ml). The decrease was significant from the initial values to those after radiotherapy (p less than 0.01). Four patients whose tumors persisted had high values (68 +/- 46 ng CEA/ml). In patients who had previously received radiation treatment for bladder carcinomas, CEA values were high in 20 with recurrences (58 +/- 36 ng CEA/ml) while they were lower in 13 who were free of recurrence (14 +/- 6 ng CEA/ml). These findings indicate that urinary CEA determinations may be used in the immediate followup and management of patients treated for bladder carcinoma. It also appears to be of prognostic significance.

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PubMedDate not supplied

Generalist and subspecialist physicians' knowledge, attitudes, and practices regarding influenza and pneumococcal vaccinations for elderly and other high-risk patients: a nationwide survey.

BACKGROUND: Influenza and pneumococcal vaccination rates remain too low. This survey assessed generalist and subspecialist physicians' knowledge, attitudes, and practices regarding influenza and pneumococcal vaccinations for high-risk patients. METHODS: A self-administered questionnaire was mailed to 6000 physicians randomly selected from a national database. RESULTS: After 3 mailings, 1874 physicians (32%) of the 5858 eligible responded. Although most physicians thought that it was very important for their high-risk patients be current on influenza and pneumococcal vaccinations, only 86% and 75% of generalists and subspecialists, respectively, very strongly recommended influenza vaccinations to their elderly patients and only 81% and 64%, respectively, very strongly recommended pneumococcal vaccinations to their elderly patients (P<.001 for both). After multivariate logistic regression, factors significantly associated with strongly recommending vaccinations to elderly patients in the influenza and pneumococcal vaccination models included female sex of provider, the provider having received an influenza vaccination, the provider's beliefs about vaccine effectiveness and cost-effectiveness, a patient's risk for illness, and ease of targeting patients. In addition, generalists were more likely than subspecialists to strongly recommend pneumococcal vaccinations to their patients. Patient reminders, special clinics, and standing orders were each used by fewer than 30% of respondents, although generalists were more likely than subspecialists to use such strategies. CONCLUSIONS: Nontrivial proportions of generalist and subspecialist physicians fail to strongly recommend influenza and pneumococcal vaccinations to their elderly and high-risk patients. Other effective strategies for promoting vaccine delivery are also used relatively infrequently. These findings suggest areas for improvement if vaccination rates are to reach national goals.

Aged↗
PubMedDate not supplied

Computer interface and software analysis for multi-channel, on-line temperature recording to any micro-computer.

A simple, inexpensive computer interface designed for in vitro or in vivo researchers with limited electronic experience allows direct on-line multi-channel temperature recording from thermistor probes to any micro-computer. The designed system saves time and increases the accuracy of collected data that are ready for storage in files compatible with graphic and statistical software. In vitro testing of the designed interface, over a range of 25-45 degrees C, showed a 0.999 intraclass correlation to reference water bath temperatures. In vivo testing using anesthetized rats involved simultaneous measurements of: (1) a thermogenic tissue, interscapular brown adipose temperature (IBAT), (2) core (colonic) temperature, and (3) surface (tail) temperature, a heat loss tissue. The temperatures measured by the designed computer-interface demonstrate excellent stability, sensitivity and accuracy when compared to respective temperatures measured by a YSI telethermometer.

Animals↗
PubMedDate not supplied

Spatial and temporal distribution of anopheline larvae in two malarious areas in Sucre State, Venezuela.

The spatial and temporal distribution of anopheline larvae was studied in two coastal malarious areas of Sucre, State, Venezuela. Seven habitat types were sampled in the village of Guayana and eight species of Anopheles were collected. Anopheles aquasalis was the predominant species collected and was most abundant in the brackish marsh habitat (71 larvae per 100 samples). It was most abundant during the rainy season. At the second location, Santa Fé, six habitat types were sampled and four anopheline species were collected. Habitats where An. aquasalis was most abundant were temporary freshwater ponds (34 larvae per 100 samples) and mangroves (10.5 larvae per 100 samples). At this location it was also most abundant in the rainy season. During the dry season it was collected in small numbers in river pools (1.3 larvae per 100 samples) along with large numbers of An. pseudopunctipennis (479 larvae per 100 samples). Larval control could be an important component of the malaria control program because major habitats could be defined and presence and abundance of larvae was limited to specific times of year.

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PubMedDate not supplied

Adult abundance, biting behavior and parity of Anopheles aquasalis, Curry 1932 in two malarious areas of Sucre State, Venezuela.

The principal vector of malaria in eastern Venezuela, Anopheles aquasalis, is exophagic and exophilic. Control using indoor insecticide house sprays has failed to lower the number of malaria cases. Therefore, studies were initiated in two villages of the eastern coastal state of Sucre to better understand this vector's biology and develop a more integrated control program. An. aquasalis was found to have a crepuscular biting behavior with a major peak at dusk and a minor peak at dawn. Mosquitos were collected more outdoors than indoors. Forty-seven percent of the biting took place before people went to bed (22:30 hr) and 69% of the mosquitos biting during this time period bite outdoors. Outdoor biting could be the reason why indoor spraying alone did not lower malaria cases. Seasonal abundance was greater in the rainy season compared to the dry season. Seasonal parous rates were high (78.3%-100%) and similar indoors and outdoors and between dry and wet season in Santa Fé. In Guayana, the seasonal parity was lower (34.6%-42.2%) than Santa Fé with indoor parity slightly higher than outdoors. Malaria cases were higher in Santa Fé, but adult mosquito density was much lower than in Guayana. This difference could have been due to higher parity in Santa Fé compared to Guayana. The greater distance to the nearest breeding site and presence of alternative hosts in Guayana can not be discounted as factors which contributed to the difference in malaria transmission between locations. We concluded that knowledge on seasonal occurrence, biting activity, resting behavior and breeding site location can be used to design a new control strategy for this vector.

Animals↗
PubMedDate not supplied

Combined hamartoma of the retina and retinal pigment epithelium in a patient with neurofibromatosis type 2.

We describe a young patient with combined hamartoma of the retina and retinal pigment epithelium who developed bilateral acoustic neuromas and meningiomas of the cervical-medullary junction and fifth cranial nerve. This case illustrates the association between combined hamartoma of the retina and retinal pigment epithelium and neurofibromatosis type 2. The authors recommend that children with a combined hamartoma of the retina and retinal pigment epithelium be screened for neurofibromatosis type 2.

Fluorescein Angiography↗