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Biomedical subjects

R Zhang

Publications and source records attributed to R Zhang.

At least 559 records · Page 31Linked to original sources
PubMed1988

Effects of combined resistive loading on the respiratory pattern and the subject's perception.

The physiological and psychophysical effects of combined flow resistive loads were studied systematically by using the Multistage Evaluation Scale (MES), determining the number of Just Noticeable Difference (JND) steps, and constructing equivalent resistive-load-sensation contours. During combined resistive loading, the relative changes of inspiratory and expiratory peak flow rate (VImax/VEmax) were related to both the JND step number and the inspiratory versus expiratory resistance ratio (IR/ER). However, the ratio VImax/VEmax was related to the IR'/ER' ratio only. The subject's perception of combined loads differing both in intensity and IR/ER ratio could be well depicted by the equivalent resistive-load-sensation contours. Hence we could define a model for predicting the physiological and psychophysical effects of various resistive loading conditions.

Humans↗
PubMed1988

Multistage evaluation scale, differential threshold steps and equivalent sensation contours of respiratory flow-resistive load sensation.

This paper presents and discusses the methodology and results of studies on respiratory sensation by using a fuzzy set category judgement model and applying the concept of just noticeable difference (JND) step and equivalent sensation. A new kind of category scale, the multistage evaluation scale (MES), based on a fuzzy set category judgement model for quantifying respiratory sensory magnitude has been put forward and verified in 37 subjects. The perceived magnitude of added resistance estimated using MES could reflect properly the difference in sensory perception caused by added loads with equal intensity but applied to different phases of the breathing cycle. In addition, the psychophysical function obtained conforms to the Stevens' power law. On the contrary, the classical category scale does not possess some of these attributes. In 9 subjects, we determined that the sensory continuum corresponding to either inspiratory or expiratory added resistive load, ranging 10-500 mm H2O.1(-1).s, consisted of 6 or 7 JND steps. The sensory magnitude corresponding to each step was estimated by the MES. Relating the results of JND step measurements with that of magnitude estimation using MES, we could elucidate systematically the relationship between perceived magnitude and discrimination for respiratory sensation. In 13 subjects, the equivalent respiratory resistive load sensation contours of 2, 3 and 4 JND step above basal level, respectively, were obtained through experimentation and by quadratic polynomial approximation of experimental data. The results suggest that as regards the human tolerance to various added resistive loads the combined resistive load is the most tolerable among the three; the expiratory, the least. The equivalent sensation contour can be used to predict the changes in respiratory sensation determined by both the intensity of the total added load and the ratio of inspiratory versus expiratory load. In brief, we have proposed a new way to elucidate the physiological and psychophysical effects of various added resistive loads.

Humans↗
PubMed1987

Synaptic association between enkephalin-containing axon terminals and proopiomelanocortin-containing neurons in the arcuate nucleus of rat hypothalamus.

By employing an electron microscopic dual immunolabeling technique, a synaptic association between neurons containing immunoreactive adrenocorticotropin (ACTH) and axonal terminals containing immunoreactive methionine-enkephalin octapeptide (Enk-8) was found in the arcuate nucleus of the rat hypothalamus. The axonal terminals contained many small clear vesicles and some large cored vesicles. At the synaptic portions, membrane specialization was asymmetric.

Animals↗
PubMed1987

Lung cancer among Chinese women.

A case-control study involving interviews with 672 female lung cancer patients and 735 population-based controls was conducted to investigate the high rates of lung cancer, notably adenocarcinoma, among women in Shanghai. Cigarette smoking was a strong risk factor, but accounted for only about one-fourth of all newly diagnosed cases of lung cancer. Most patients, particularly with adenocarcinoma, were life-long non-smokers. The risks of lung cancer were higher among women reporting tuberculosis and other pre-existing lung diseases. Hormonal factors were suggested by an increased risk associated with late menopause and by a gradient in the risk of adenocarcinoma with decreasing menstrual cycle length, with a 3-fold excess among women who had shorter cycles. Perhaps most intriguing were associations found between lung cancer and measures of exposure to cooking oil vapors. Risks increased with the numbers of meals cooked by either stir frying, deep frying or boiling; with the frequency of smokiness during cooking; and with the frequency of eye irritation during cooking. Use of rapeseed oil, whose volatiles following high-temperature cooking may be mutagenic, was also reported more often by the cancer patients. The findings thus confirm that factors other than smoking are responsible for the high risk of lung cancer among Chinese women and provide clues for further research, including the assessment of cooking practices.

Adenocarcinoma↗
PubMed1987

Cytokinin Biochemistry in Relation to Leaf Senescence : II. The Metabolism of 6-Benzylaminopurine in Soybean Leaves and the Inhibition of Its Conjugation.

The metabolism of [(3)H]6-benzylamino purine was studied in presenescent and early senescent soybean (Glycine max [L.] Merr.) leaves. In both types of leaves, the metabolism was essentially the same. The principal metabolite was identified as beta-(6-benzylaminopurin-9-yl)alanine by mass spectral studies, which included discharge ionization-secondary ion mass spectrometry and pulsed positive ion-negative ion-chemical ionization mass spectrometry. Conversion to this alanine conjugate was found to be inhibited 2,4-dichlorophenoxyacetic acid and 5,7-dichloroindoleacetic acid.

Journal Article↗
PubMed1985

Peripheral chemoreceptors in respiratory oscillations.

The hypothesis that instability of cardiorespiratory control may depend on the response and sensitivity of carotid body chemoreceptors to arterial blood gases was studied in anesthetized cats under three different experimental conditions. 1) Following administration of the peripheral dopamine receptor blocker [domperidone (0.6-0.8 mg X kg-1, iv)], carotid chemoreceptor activity and its sensitivity to CO2 during hypoxia increased, leading to cardiorespiratory oscillations at low arterial PO2 in four of eight cats. Inhalation of 100% O2 promptly decreased chemoreceptor activity and eliminated the oscillations. Inhalation of CO2 stimulated the chemoreceptor activity and ventilation but did not eliminate the oscillations. Bilateral section of carotid sinus nerves abolished the cardiorespiratory oscillations. The implication is that the dopaminergic system in the carotid body keeps chemoreceptor responses to blood gas stimuli suppressed and hence cardiorespiratory oscillations damped. 2) Hypotension and circulatory delay induced by the partial occlusion of venous return led to cardiorespiratory oscillations at low but not at high arterial PO2. 3) A few cats developed cardiorespiratory oscillations without any particular experimental intervention. These oscillations were independent of arterial PO2 and chemoreceptor activity. Thus it is reasonable to conclude that the peripheral chemoreflex can play a critical role in developing cardiorespiratory oscillations in certain instances.

Animals↗