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Biomedical subjects

R Zelis

Publications and source records attributed to R Zelis.

224 records · Page 13Linked to original sources
PubMedDate not supplied

Regional vascular and hemodynamic effects of orally administered nisoldipine in conscious rats.

This study examined the hemodynamic and regional vascular effects of orally administered nisoldipine, a new dihydropyridine derivative (0.3 mg/kg) in normal conscious rats (n = 10). Nisoldipine significantly reduced systemic vascular resistance (0.58 to 0.38 mm Hg kg min/ml, p less than 0.05) and mean arterial pressure (122 to 108 mm Hg, p less than 0.05), and increased heart rate (395 to 447 beats/min, p less than 0.01) and cardiac index (225 to 326 ml/beat/kg, p less than 0.05). Left ventricular end-diastolic pressure was slightly decreased by nisoldipine (9.6 to 3.8 mm Hg, p less than 0.05). Blood flow (radioactive microspheres, 15 +/- 5 micron in diameter) to heart, gut, kidney, and brain was significantly increased. Improvement of blood flow was most pronounced in the coronary circulation (+ 58%) followed by the gut and renal circulatory beds. We conclude that nisoldipine represents a new orally effective calcium antagonist with highly selective effects in vascular smooth muscle as compared with its direct cardiac effects. The results are compared with our previous study utilizing intravenous nisoldipine.

Administration, Oral↗
PubMedDate not supplied

Pressure-flow relationships in the peripheral circulation of the dog with practolol.

1. The influence of practolol (a proposed beta1-adrenoreceptor antagonist) upon the pressure-flow relationships in the peripheral circulation was studied in eight anaesthetized dogs during right heart by-pass procedures. 2. Practool (1 mg/kg) produced a significant increase in the resistance to venous return which resulted in a significant fall in venous return. 3. There was no significant change in arterial resistance. 4. This study suggests that practolol should not be classified as an exclusive cardioselective beta-adrenoreceptor antagonist.

Animals↗