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Biomedical subjects

R Yamaguchi

Publications and source records attributed to R Yamaguchi.

At least 199 records · Page 11Linked to original sources
PubMed1984

[Mechanism of exercise-induced ST segment deviation in myocardial infarction: a 201T1-myocardial scintigraphic study].

Exercise-induced ST segment deviation was investigated using thallium-201 myocardial scintigraphy and correlated with coronary artery lesions in 25 patients with old myocardial infarction. Seven of eight patients without ST deviation showed no reversible perfusion defect by near maximal exercise, and six had no significant stenosis in the coronary arteries perfusing the non-infarcted area. During exercise, ST segment depression was induced in 12 patients and six of them developed a reversible perfusion defect in the non-infarcted area, associated with significant stenosis of the corresponding coronary arteries. Remaining six patients, however, did not show a reversible perfusion defect and four of them had no significant stenosis of the coronary arteries perfusing the non-infarcted area. In nine patients with exercise-induced ST segment elevation in leads with Q waves, a reversible perfusion defect was not detected in seven (78%) and five (71%) of them had no significant coronary artery stenosis as well. Four patients developed both ST segment elevation in leads with Q waves and ST segment depression in other leads. One patient who had significant coronary artery stenosis in the non-infarcted area and showed a reversible perfusion defect developed 1.5 mm ST elevation in II, III, a VF leads and 4 mm ST depression in precordial leads. In the remaining three patients who did not show a reversible perfusion defect and significant coronary artery stenosis in the non-infarcted area, ST depressions were less than 2 mm.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMed1983

Pathology of hepatocellular carcinoma in Japan. 232 Consecutive cases autopsied in ten years.

The pathologic findings of 232 consecutive cases of hepatocellular carcinoma (HCC) autopsied during the past ten years at Kurume, Japan, were analyzed from the point of view of global epidemiology, in relation to clinical feature, and in regard to incidence, age, sex, etiologic factors, size of liver, changes in noncancer parenchyma, gross type of tumor, extrahepatic metastases, intravascular and intraductal growths, cancer cell histology, hepatitis B surface antigen (HBsAg) in hepatocytes and cancer cells, liver cell dysplasia, and frequency and clinicopathologic characteristics of minute HCC. Furthermore, postmortem hepatic arteriography and portography were done in 152 livers for comparison with gross anatomy and celiac angiograms. It was found that: (1) epidemiologically, HCC in Japan is distinct from that in the West that it is frequently encapsulated, livers are generally small because of frequent and advanced cirrhosis and small cancer, minute HCC, is not uncommon at autopsy, cirrhosis most commonly associated is the one with thin stroma and medium size nodules, and micronodular cirrhosis is very rare despite frequent alcohol abuse; (2) HCC is increasing in incidence; (3) HBsAg is frequently found in parenchyma; (4) liver cell dysplasia is indirectly related to HBsAg with no evidence for premalignancy; (5) the lung is the most frequent site of metastasis but peritoneal dissemination is unusual; (6) intraportal tumor growth is very common and the hepatic vein is less frequently affected; (7) growth in the major bile duct is frequently associated with intraportal growth and clinically presents as obstructive jaundice; and (8) tumor is supplied solely by arteries and celiac arteriograms are closely correlated with gross pathologic findings.

Adenoma, Bile Duct↗
PubMed1983

[Postirradiation malignant fibrous histiocytoma in a patient with squamous carcinoma of the uterine cervix--an autopsy case].

An autopsy case of postirradiation sarcoma is described. The tumor, a malignant fibrous histiocytoma, occurred in the radiation fied 7 years after postoperative external beam radiation therapy (6000 rad) for squamous cell carcinoma of the cervix. To our knowledge, 11 cases of postirradiation malignant fibrous histiocytoma have been reported in the literature and only one occurrence of this neoplasm after treatment for cervical cancer has been described. We review the literature on postirradiation sarcoma with special attention to malignant fibrous histiocytoma.

Bone Neoplasms↗
PubMed1983

[Effect of cefotaxime in the treatment of infections associated with hematologic diseases].

Twenty patients suffering from severe infections (9 with respiratory tract infection, 9 with urinary tract infection, 2 with pharyngitis, 1 with enteritis and 4 with fever of unknown origin (FUO] were treated by intravenous infusing CTX 2 g over 30 to 40 minutes 2 or 3 times daily for 4 to 10 days. Other antibiotics were concomitantly used in 9 cases. Response to CTX was proved good in 15 cases (75%), fair in 3 cases and poor in 2 cases. No adverse reactions were observed.

Adolescent↗
PubMed1981

Correlation between growth potential of mouse hepatitis viruses in macrophages and their virulence for mice.

Correlation between the virulence of mouse hepatitis virus (MHV) for mice and the growth potential of the virus in peritoneal adherent cells was observed for highly virulent MHV-2 and avirulent MHV-1, JHM, and MHV-S strains. However, this phenomenon was not observed in strain MHV-3, which multiplied to almost the same degree in peritoneal adherent cells from susceptible and resistant mouse strains.

Animals↗
PubMed1981

Conditions of clinical recovery from partial facial palsy caused by injury to a branch of the facial nerve.

This study was conducted to elucidate the pattern of clinical recovery from partial facial palsy caused by injury to a branch of the facial nerve in rabbits. In the experiment, the state of recovery from palsy was investigated by observing the movement of the m. orbicularis oris of the rabbit at the time of food intake, as well as by observing the evoked wave and muscle contraction caused by nerve stimulation, and the muscle contraction caused by muscle stimulation. Recovery from peripheral facial nerve palsy is complete within 1 month after nerve impairment if over half of the nerve fibers of the impaired nerve are maintained intact without degeneration.

Animals↗
PubMed1979

Uteroplacental blood flow and uteroplacental shunt rates in normal and prolonged pregnancies in rats.

To reveal the regulatory function in uteroplacental blood flow we measured, using the method of double tracer microspheres, the rates of uteroplacental blood flow (UPBF) and uteroplacental shunt (UP-shunt) in SD-strain rats of normal and prolonged pregnancy. (1) In the group of rats of normal pregnancy, the rate of UPBF attained a peak on the 20th day of gestation, while the UP-shunt rate was highest on the 18th day of gestation. (2) In the progesterone-induced prolonged pregnancy group, the rate of UPBF remained at an 8% level until the the 22nd day, i.e., the first day of prolonged pregnancy, and dropped to 6.6% on the 23rd day. The UP-shunt rate in the progesterone-administered group was about 27% on the 20th day, more favorable than the corresponding rate in the normal group, but thereafter rapidly decreased. The rate of increase in fetal body weight in this group became lower, showing a fetal death rate of 4.6%. (3) The decreases in placental alkaline phosphatase and leucine aminopeptidase examined as markers of placental function lagged behind the fall in the UP-shunt rate. On the 23rd day of gestation when the rates of UPBF and UP-shunt dropped, the decreases in their placental enzyme activities were remarkable.

Alkaline Phosphatase↗
PubMed1979

Use of curves for prediction of maternal blood levels of placenta-specific substances for diagnosis of placental function.

Maternal blood levels of cystine aminopeptidase (CAP), human placental lactogen (HPL) and beta 1 glycoprotein (SP-1) were predicted and evaluated using the expressions and their charts developed by us to help diagnosis of placental function in women of the third trimester of pregnancy. This study was conducted on the assumption that these placenta-originating substances as markers would behave similarly to the previously reported heat-stable alkaline phosphatase (HSAP). The results realized the following features: (1) CAP, HPL and SP-1, like HSAP, had their normal ranges of values too wide to be based on for diagnosing placental function in general, but it was confirmed that on the individual basis these marker substances could develop adequate "prediction curves" for their values to come well answering to the test in the same way as with HSAP. (2) The expressions for predicted values revealed that these marker substances in their shift in the maternal blood had different critical points start of deviation from exponential rising. Particularly in abnormal pregnancy, their shifting patterns were often dissimilar to one another, with implications that impaired placental function could possibly be confirmed qualitatively by reference to the predicted curve for the values of either of the marker substances.

Aminopeptidases↗