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Biomedical subjects

R Yagil

Publications and source records attributed to R Yagil.

At least 55 records · Page 3Linked to original sources
PubMed1975

Effect of litter size on milk yield in the rat.

The amount of milk removed from rats during 1 hour's suckling after a separation period of 8 hours was estimated by weighing their pups. In the 1st experiment litters of 9 pups were suckled by all rats. At test sucklings held daily on days 6-15 of lactation, pups were reallocated to give 3, 6, 9, 12 or 15 pups per dam. The largest amount of milk was removed at suckling by groups of 12 pups. In a 2nd experiment, rats were constantly sucked by litters of either 3, 6, 9, 12 or 15 pups from birth to slaughter at 15 days post partum. Rats with 12 and 15 pups yielded the most milk, nearly twice as much as those suckling only 6 or 9 pups. Litters of 3 pups consumed less than 1/3 of the amount consumed by litters of 6 or 9 pups.

Animals↗
PubMed1975

The aetiology of senile osteoporosis: secondary hyperparathyroidism due to renal failure.

The aetiology of senile osteoporosis was investigated in a series of elderly normal persons (mean age 76.8 years) who were compared to 18-19 year old normal controls. Osteoporosis was estimated by standard radiological morphometric and densitometric techniques, in the metacarpals and thoraco-lumbar vertebrae. Serum parathyroid hormone levels were significantly higher in the elderly group, and correlated well with morphometric and densometric measurements of osteoporosis. Creatinine clearance was reduced in seven out of nine of the elderly group, and correlated well with the degree of osteoporosis. Serum thyrocalcitonin levels were reduced in the elderly. Tubular reaborption of phosphate and TmP/GFR were in the hyperparathyroid range in the elderly group and correlated well with the degree of osteoporosis. The hypothesis is advanced that the osteoporosis of old age is a result of parathyroid overactivity, caused by asymptomatic chronic renal failure. The suggestion is made that a diet low in phosphorus might reduce the incidence of osteoporosis in old age by reducing the parathyroid overactivity.

Adolescent↗
PubMedDate not supplied

Effect of oxidative stress on avian erythrocytes.

Avian erythrocytes differ from mammalian erythrocytes in being nucleated and oval. In the circulation, chicken cells survive for only 35 days, compared to 120 days for human cells. In humans, red cell oxidation processes, involving methemoglobin formation, have been correlated with cellular aging. This study compared oxidative resistance of two avian red cells (chicken and ostrich) to that of discoid enucleated human cells. Reduced glutathione levels (GSH) and methemoglobin were higher in chicken and ostrich cells than in human cells. SOD levels were higher in human cells. Diamide exposure diminished intracellular GSH levels in all species, with the greatest effect on human cells. Regeneration potential was high for all cells. Ostrich cells were more sensitive to hydrogen peroxide when hemoglobin oxidation was involved; BHP exposure affected GSH depletion and methemoglobin production in ostrich cells more than in the others. Lipid peroxidation was found to be highest in the human cells. Chicken cells were only slightly more resistant than human cells. Our data suggest that the extensive, complex oxidation by BHP cannot represent in vivo aging processes. In addition, the milder, selective oxidation by diamide affects human cells (endowed with long life span) more than avian cells. It is concluded that in vitro oxidation by diamide and BHP cannot be correlated with red cell survival.

Adult↗