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Biomedical subjects

R Y Calne

Publications and source records attributed to R Y Calne.

At least 361 records · Page 20Linked to original sources
PubMed1970

Survival after orthotopic liver transplantation: a follow-up report of two patients.

Two adult patients with terminal fatal liver disease were treated by orthotopic transplantation. One survived 11 months and died as a result of recurrent biliary intra-abdominal sepsis; the other patient is alive and well in the 18th month after transplantation and has virtually normal liver function. It is concluded that liver grafting can provide valuable therapy.

Adult↗
PubMed1969

Liver transplantation in man--3, Studies of liver function, histology, and immunosuppressive therapy.

The experience gained from 13 hepatic transplant operations is described, with particular reference to the findings in nine patients who survived the immediate operative period. A major problem was found to be infection. Fulminant pneumonia caused death in two adults, at a time when liver function was virtually normal. Infection related to bile fistula and sepsis may be overcome by an improved method of biliary drainage by cholecyst-dochostomy, which was carried out in the last two patients. Jaundice in the second week due to rejection was observed in several patients. The striking histological change was centrilobular cholestasis. The jaundice, which was not prevented by administration of antilymphocyte globulin, was rapidly controlled by temporarily increasing die dose of prednisone. One patient who survived for four and a half months and who had a poor tissue match subsequently developed chronic rejection with progressive cholestatic jaundice. Five of the patients were able to go home and at time of publication two are alive and well 14 and 20 weeks after treatment.

Adolescent↗
PubMed1969

Liver transplantation in man--IV, Haemorrhage and thrombosis.

Blood coagulation and fibrinolytic factors have been measured in 13 patients treated by liver transplantation. During operation intravascular coagulation and fibrinolysis were increased, but seldom to a degree which would cause abnormal bleeding. Measurement of the catabolism of radioactive fibrinogen showed that increased intravascular coagulation continued for long periods after the operation. Despite secondarily increased fibrinolysis, there was a high incidence of thrombosis. Treatment with anticoagulants or with fibrinolysis inhibitors may be valuable in these patients.

Adult↗