Biomedical subjects
Publications and source records attributed to R Winter.
In a randomized study the local anesthetic side effects of the beta blockers Metipranolol and Timolol were compared. With the new electronic optical esthesiometer accurate, reproducible sensibility measurements are now possible. It can be shown that both beta blockers have a brief local anesthetic effect when applied to the cornea in drop form. There is also a relation between dose and effect.
The authors compare patient characteristics in a psychiatric emergency setting in the United States with a similar service in the United Kingdom. They found that despite many significant differences in nonclinical variables, the severity of clinical symptoms did not differentiate between the two groups. In both countries, it was not the degree of psychopathology but the lack of an available support network, an inability to engage the patient in the system, and a history of serious chronic maladjustment that led to the majority of "emergency" visits. The authors conclude that use of an emergency service sensitivity mirrors the gaps in health care delivery.
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Hyaluronic acid facilitates and maintains separation of dissected structures in glaucoma microsurgery, thus preventing complications during surgery and in the immediate postoperative phase. Goniotomy is more easily controlled and is safer. Hyaluronic acid can therefore be used in glaucoma microsurgery to keep prepared layers of tissue separated for longer and can enlarge newly created space and almost eliminate the adhesive forces between the layers. Using hyaluronic acid the safety of glaucoma microsurgery is enhanced and the complication rate reduced. High elastic viscous substances offer better technical possibilities in microsurgery. Further experience is necessary before a final judgement can be made on the advantages.
In 25 insulin-dependent female diabetics of the B to D categories according to White, the daily insulin requirement was determined between the 8th and 40th week of pregnancy. The purpose of this study was to keep the mean blood sugar below 100 mg% by means of administration of old insulin. From the 28th week the metabolic balance was additionally modified by means of the insulin content of the amniotic fluid. In all cases spontaneous initiation of delivery was awaited. All women gave birth to healthy babies of normal weight without any sign of diabetogenic foetopathy. The insulin requirement of the whole group rose from an average of 32 units in the 8th week to 66 units in the 36th week of pregnancy and decreased subsequently. The requirement increases at first as represented by a flat curve which acquires a distinctly greater slope between the 28th and 36th weeks. In White B, C, and D diabetics the initial requirement is on the average 23, 35 and 45 units per 24 hours. the maximum requirement being on the average 2.4, 2.0 or 1.7 times the initial figure. The drop in insulin requirement after the 36th week is physiological and does not point to any hazard as far as the foetus is concerned.
In implant surgery there is more damage to the endothelium than in normal cataract extraction. This damage results from the implant coming into direct contact with the endothelium during surgery. To minimize this contact, hyaluronic acid was instilled into the anterior chamber between the implant and the endothelium. The effect of this procedure post-operative endothelial cell density was investigated in a clinical study. The result was found to be a decrease in endothelial cell loss.
The cardiovascular effects of aural irrigation with water at 37 degrees C (control subjects, n = 6) or 44 degrees C (experimental subjects n = 11) were assessed from measurements of heart rate, brachial arterial blood pressure and forearm blood flow. The occurrence and intensity of vestibular stimulation was assessed from the electronystagmogram. The procedure had no significant effect on cardiovascular variables in control subjects or in subjects who were exposed to vestibular stimulation but who were not nauseated by it (n = 6). Those subjects who felt nauseous (n = 5) showed a tachycardia and forearm vasodilatation. These results provide no evidence that vestibular stimulation contributes to orthostatic reflexes in man.
A female is reported, which showed motor and sensory disturbances following severe hypokalemia induced by abuse of diuretics. Elevated CSF-protein and abnormal neurographic findings with restitution after substitution with potassium led to the diagnosis of a neurogenic involvement like a Guillain-Barré syndrome. In the literature similar cases are described. So it seems, that beside of myopathic changes neurogenic disturbances can appear as a neurological symptom of hypokalemia.
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Between 1/7/1974 and 30/6/1979 we analysed 532 amniotic fluid cell cultures. In 402 cases a genetic indication for amniocentesis was given; 57 prenatal diagnoses were carried out for gynaecological and other medical indications. We also analysed 73 amniotic fluid test samples. Altogether 19 pathological results (3.6%) were found. We observed 16 abnormal findings in 459 diagnostic amniocenteses and 3 pathological results in the test cultures. The transmission of parental chromosomal polymorphisms to the fetus is discussed here. The importance of prenatal diagnosis in genetic counselling, along with cost-benefit reflections, are stressed in this paper.
High demands are made on the visual perception of individuals involved in driving, navigation and aviation. Aphakic subjects in particular may attain good central function after operation, but are subject to stringent regulations with regard to their fitness to drive, etc. Their uncorrected vision and visual fields are poor. If only one eye is aphakic there are problems especially with binocular vision. Only the implantation of an artificial lens can return the eye to a "normal" condition. Since, for many patients, driving etc. is an essential part of their occupation, there is also a social problem involved. The authors believe that such considerations justify implantation of a lens. Even where very high demands are made on function, as in the case of airline pilots, vision is fully satisfactory for traffic purposes following artificial lens implantation.
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Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.