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Biomedical subjects

R Winkler

Publications and source records attributed to R Winkler.

At least 217 records · Page 12Linked to original sources
PubMed1976

Urological aspects of primary retroperitoneal tumours.

An analysis of 50 primary retroperitoneal tumours is presented with emphasis on the urological aspect. 70-80% of the tumours were malignant and sarcomas predominate. The tumour mass was palpable in over 70% of the cases. Frequent involvement of the urinary tract caused lumbar pain in 78% of cases. Intravenous urography and retrograde pyelography are the greatest single aids in accurate diagnosis of primary retroperitoneal tumours since over 70% show abnormalities. Selective angiograms may define the size and operability of the tumour. When diagnosed, extirpation of the tumour is possible in only 30-40% of cases. Postoperative mortality is about 10%. Since 70% of these tumours are radiosensitive, radiotherapy improves the prognosis. Survival for more than 2 years after surgery is exceptional.

Adult↗
PubMed1975

[Gastric neurinoma (author's transl)].

The pathologic, symptomatic, diagnostic and therapeutic characteristics of gastric neurinoma are demonstrated on the basis of 5 cases of the author's own case material. This rare gastric tumour accounts for 0.2% of all gastric tumours and has it's special importance for the diagnostic differentiation of gastric carcinoma and sarcoma. The maximum incidence is between age 50 to 60. Typical symptoms are acute gastro-intestinal bleeding, chronic gastric pain and palpable tumour in the epigastrium with relatively good general condition. Laboratory findings are not specific, X-ray examination and gastroscopy can be at best tentative. Resection is the therapy of choice, because potential malignancy accounts for 10 to 15% and the complications as bleeding and perforation can be dangerous. The prognosis is good even in cases of sole local excision, no recidives were found.

Cell Transformation, Neoplastic↗
PubMed1975

[Recurrence of rectal cancer (author's transl)].

36 cases of recurrent rectal cancer are reported. There is a wide-spread spectrum in the appearance of the relapse. Indirect symptoms are dominating. The most frequent of them are caused by obstruction of the bowl or the urinary pathways and by irritation of (lumbo-) sacral nerves. Especially rare manifestations are stressed. Often they are hardly regarded early symptoms of the recurrent cancer. Curative therapy was made 5-times by amputation, 2-times by resection of an anastomosial recurrence. 3 of these patients reach a survival rate over 18 months until now. An isolated pulmonary late-metastasis was removed by lobectomy; this patients shows no recurrence for the last 3 years. Palliative procedures took place in 20 patients. The worth of radiation therapy is to be seen in a (temporary) reduction of pain. Chordotomy remains as ultima ratio for uninfluencable pain.

Cordotomy↗
PubMed1975

[Urologic complications in rectal surgery (author's transl)].

Urinary disorders after amputation or resection of the rectum are much more frequent than commonly supposed. Out of 239 patients they were noticed by 56.6%, undergoing amputation, and 36.6% after resection. Longterm disturbances were observed by 26.4% respect. 15.1%. The most important reason is injury of autonomic pelvic nerves and ganglia. Urinary bladder infection was verified in 22% respect. 8%. Furthermore urinary disorders may be caused by changing of bladder localization (bladder hernia), wound infection (especially of the sacral cavity), edema of the urethra, and exacerbation or manifestation of pre-existing urologic diseases. Compared to these, lesions of the urinary tract are of little importance. To prevent such complications, we postulate: 1. careful pre-operative urologic examination, 2. if possible mobilisation of the rectum along its borderlines (so-called Grenzlamellen of Pernkopf), 3. critical analysis of urologic disorders, removal of the urinary catheter as soon as possible, regular systemic prophylaxis of urinary infection, and therapy controlled by antibiogram, 4. adequate follow-up, and 5. urologic examination of all disturbances lasting longer than three months.

Age Factors↗
PubMed1975

[The so-called inoperable rectal carcinoma. Simultaneously, a contribution to the prognosis of rectal carcinoma].

Rectal cancer is quite easy to identify. Simple methods of investigations and early symptoms should allow a good prognosis. This is patholphysiologically supported by slow increasement and relatively late filialisation along long metastatic roads. Therefore it is to be regretted, that of 632 patients, suffering from rectal cancer in the years 1955-1970, 179 (28,3%) could not be treated on cure. Even palliative procedures had a postoperative mortality of 24,6%. This delay in early diagnose reduced the time of survival from 72% 2-jears-survival, when operated on cure (see article) to 59,1% (see article), respectively from 52,1% 5-years-survival (see article) to 38,5% (see article). These results can be only improved by regular prophylactic examinations.

Germany, West↗
PubMed1975

Denaturation of collagen fibers in NaI, NaCl and water of different pH values as studied by differential scanning calorimetric measurements.

Microcalorimetric measurements of rat tail tendon collagen in different aqueous media show the following behavior of denaturation temperature (Td) and of denaturation enthalpy (deltaHd): H+ and OH- ions lower Td significantly beyond pH 4...11. Addition of salts (0.15 M) generally lowers Td in the range between pH 5 and 10, I- being more effective than Cl- at pH greater than i.p. However, in the region of pH less than i.p., I- raises Td to values above those of Cl- and even those of water. The value of deltaHd was found to be insensitive to pH over the pH range of 4...11. Hence the lowering of Td is assumed firstly to be due to a (ionic) disorganization of the water contacting the polypeptide chains and secondly to their mutual electrostatic repulsion. The appearance of deltaHd is thought mainly to be due to a rupture of interchain bonds.

Animals↗