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Biomedical subjects

R Whang

Publications and source records attributed to R Whang.

At least 55 records · Page 3Linked to original sources
PubMed1981

Magnesium and potassium interrelationships, experimental and clinical.

1) Coexisting Mg and K deficiency may occur with greater frequency than has been previously appreciated. 2) Profound hypokalemia, or refractoriness to K repletion or coexisting hypokalemia and hypocalcemia should suggest the possibility of concurrent Mg and K depletion. 3) The identification and treatment of concurrent K and Mg depletion is especially important in patients with congestive heart failure because of problem of digitalis toxicity. 4) We believe that the role of magnesium in optimizing cardiac function remains to be elucidated, identification and treatment of coexisting Mg and K depletion will be facilitated by making serum Mg a routine electrolyte determination together with Na, K, Cl, CO2.

Adult↗
PubMed1981

Efficacy of intravenous phosphorus therapy in the severely hypophosphatemic patient.

To evaluate the efficacy and safety of a simple approach to intravenous (IV) phosphorus therapy, ten adult patients with severe hypophosphatemia (less than or equal to 1 mg/dL) and normal renal function were studied prospectively. They were treated with a solution containing 9 mmole of phosphorus as monobasic potassium phosphate (KH2PO4), infused continuously every 12 hours. Serum phosphorus, potassium, and calcium levels and urinary excretion of phosphorus were measured every 12 hours. The serum phosphorus level was significantly improved at 12 hours, more than 1 mg/dL in all patients at 36 hours, and normal in six patients at 48 hours. The serum potassium level was never above normal, and serum calcium levels declined in only one patient. Administration of 9 mmole of phosphorus as KH2PO4 every 12 hours is both safe and efficacious IV therapy for severe hypophosphatemia in the adult patient with normal renal function and without hyperkalemia or hypercalcemia.

Acute Disease↗
PubMed1977

Preoperative administration of fluids.

A study by questionnaire was sent to 134 Surgical Services at Veterans Administration Hospitals to ascertain the prevalence of the practice of preoperative hydration during the period of hydropenia preceding surgery. A 92.5 per cent response was noted and the following conclusions are drawn: (1) The majority of Veterans Administration Surgical Services do not routinely provide intravenous fluids during the immediate preoperative period. (2) Affiliation with a medical school-based postgraduate training program does not alter significantly the proportion of Surgical Services providing preoperative intravenous therapy on a routine basis. (3) These observations suggest a need for Surgical Services to assess the desirability and indications of preoperative hydration. (4) However, in the case of chronic renal failure patients there is little question of the necessity for careful preoperative, intraoperative, and postoperative hydration.

Evaluation Studies as Topic↗
PubMed1975

Reversible renal concentrating defect in shock.

The loss of renal concentrating power in haemorrhagic shock is reversible upon correction of the shock state. Shock resulting from acute hypovolaemia leads to the following sequence of events: (1) diminished renal blood-flow; (2) decreased superficial cortical nephron perfusion; (3) continued juxtamedullary nephron perfusion; (4) enhanced proximal reabsorption of Na, Cl, and H23; (5) decreased delivery of these ions to the ascending limb, which results in diminished hypertonicity of the medullary interstitium. This hypotonicity is worsened by the "washout" effect on the interstitial hypertonicity caused by continued perfusion of the juxtamedullary vasa recta which results in (6) diminished renal concentrating capacity due to elimination of medullary hypertonicity. Replenishing blood-loss and correcting the hypovolaemic state "regenerates" the hypertonic renal medullary interstitium by (a) diminishing proximal reabsorption and allowing presentation of greater quantities of Na and Cl to the ascending-limb "pump", (b) restoring superficial cortical nephron perfusion, thereby decreasing juxtamedullary perfusion and in this manner eliminating medullary "washout".

Animals↗
PubMed1975

Simultaneous determination of extracellular fluid and total body water. I.

A method for the simultaneous determination of extracellular fluid volume by radiosulfate-35 and total body water by tritiated water is described. Protein was precipitated from plasma with 10 per cent trichloroacetic acid. Radiosulfate-35 and tritiated water were counted in a dual-channel liquid scintillation spectrometer, using an automatic external standard to correct for quench. The sulfate space was calculated by the isotope dilution principle. Crossover counts contributed by radiosulfate-35 into the tritium channel were subtracted from the total counts in that channel. The tritiated water space was then calculated by the isotope dilution principle. Studies were performed in vitro and in 8 bilaterally nephrectomized rats. In vitro extracellular space by radiosulfate-35 and total body water by tritiated water demonstrated less than 3 per cent variation from the predicted volumes. In the rat, total body water determined with tritiated water demonstrated 4 per cent variation from that determined by desiccation. The method is simple, accurate, reproducible, and readily applicable for use in man and animals.

Animals↗