-C57BL/6 mice were intubated from gestational day 14-18 twice daily with 1.58 g/kg ethanol, 4.2 g/kg sucrose, or remained untreated. Offspring of ethanol treated or lab chow control groups were raised either by group-housed dams and weaned on postnatal day (PND) 28 or by individually housed dams and weaned on PND 21. Offspring of the sucrose control group were raised by individually housed dams and weaned on PND 21. Groups did not differ in pup weight or litter size. Offspring were assessed for home-cage activity (PND 36-38) and open-field behavior (PND 40-42). Mice prenatally exposed to ethanol showed increased activity in their home cages, whereas open-field behavior was generally not different from that of control groups. Conversely, different preweaning rearing conditions had affected open-field behavior, but not home-cage activity. In conclusion, home-cage behavior was a sensitive paradigm for detecting hyperactivity subsequent to a relatively low dose of prenatal ethanol in mice, and communal nesting/late weaning vs. individual nesting/ standard weaning may be a useful preweaning environmental manipulation to study possible modifications of prenatal neurobehavioral effects.

Animals↗

PubMedDate not supplied

Medical screening of office workers for upper extremity cumulative trauma disorders.

An apparent "outbreak" of cumulative trauma disorders (CTDs) was noted in a subset of white-collar workers employed in medical illustration and medical graphic arts. Among graphic artists (n = 7), there were three cases of carpal tunnel syndrome (CTS), based on patient reports of personal physician diagnoses; no such reports occurred among other workers in the department (n = 39, p = .0023, Fisher's exact test). Jobs were studied to identify possible risk factors for CTDs, and workers underwent a standardized medical screening protocol. Specific work elements were found to be performed more frequently by graphic artists and appeared to be related to increased reporting of distal upper extremity symptoms and electrodiagnostic changes at the wrist. Nevertheless, using a strict case definition of CTS that required electrophysiologic evidence of median mononeuropathy at the wrist and appropriate symptoms or signs, only two persons--one graphic artist and one comparison subject--had evidence of mild CTS. The approach employed in this study of an outbreak of CTDs is an example of a multidisciplinary investigation of CTDs in an office setting.

Adult↗

PubMedDate not supplied

Utilization of child care to increase workshop participation.

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Child↗

PubMedDate not supplied

Surviving academia.

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Faculty, Nursing↗