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Biomedical subjects

R Weitzel

Publications and source records attributed to R Weitzel.

10 recordsLinked to original sources
PubMed1991

Library services for primary health care.

The paper highlights the grossly inadequate provision of library and literature information services for health care staff in the developing countries. It identifies the different types of information needs (current awareness, clinical inquiries) and makes suggestions how these could be met by simple and inexpensive means. The various administrative, organizational and financial problems that may have to be overcome are discussed. Hope is expressed that at medium or longer term more sophisticated services will become feasible through the application of information technologies.

Costs and Cost Analysis↗
PubMed1985

Immunologically discrete conformation isomers of I-A locus-equivalent class II molecules detected in Lewis rats.

Monoclonal antibodies MRC-OX6 and MRC-OX3 were used to define biosynthetically inter-related subsets of I-A-equivalent class II molecules from Lewis rat spleen cells. MRC-OX6 was shown to recognize specifically multiple forms of the class II molecule arising along its maturation pathway from the origin of polypeptide chain synthesis, the rough endoplasmatic reticulum, through the Golgi compartment to the plasma membrane. Three MRC-OX6-reactive polypeptide chain complexes were distinguished: (a) an early complex composed of immature components of the polymorphic alpha,beta heterodimer in noncovalent association with immature proteins of the invariant gamma-chain group p40, p33 (gamma), p28, p20; (b) a biosynthetic intermediate comprising the subunits alpha,beta and gamma all of them being extensively glycosylated and sialylated. The latter constituent is referred to as p36; (c) a cell surface structure consisting of the mature alpha,beta heterodimer devoid of the mature invariant chain p36. A two-dimensional (2D) separation pattern exhibited by an MRC-OX6-specific immunoprecipitate from spleen cells labeled for 4 h represents a superposition of these three MRC-OX6-reactive polypeptide chain complexes. In contrast, MRC-OX3 recognizes exclusively a fully mature alpha,beta heterodimer devoid of protein precursor forms and devoid of any invariant chains. Considering the previous observation that the respective alpha and beta subunits of MRC-OX6 and MRC-OX3-specific molecules comigrate on 2D O'Farrell gels combined with the data of this investigation, it is suggested that the mature MRC-OX6-specific alpha,beta heterodimer and the mature MRC-OX3-specific alpha,beta heterodimer originate from the same biosynthetic intermediate. We propose that before entering the plasma membrane an MRC-OX6-reactive molecule composed of fully glycosylated alpha, beta and p36 releases its post-translationally processed gamma chain (p36), giving rise to two conformation isomers, one alpha,beta heterodimer still being reactive with MRC-OX6 and one alpha,beta heterodimer which has lost the serologic MRC-OX6 and gained the MRC-OX3 specificity. Both alpha, beta heterodimers are expressed on the cell surface as two distinct subsets of I-A-equivalent class II molecules.

Animals↗
PubMed1976

MEDLINE services to the developing countries.

Supplying MEDLINE services to a widely dispersed user population in the developing countries creates numerous problems not encountered by other MEDLINE centres. The inability to interact with the user complicates system promotion and makes search formulation sometimes a gamble. Nevertheless, an evaluation survey has shown high user satisfaction. Of great concern is the still inadequate solution of document delivery. Near-term objectives are the broadening of geographic coverage and the integration of search processing with supporting hard copy supply.

Developing Countries↗
PubMed1976

[Comparison of labour induction with intravenous prostaglandin E2 and intravenous oxytocin (author's transl)].

Based on our results we are able to attribute to the PGE2 a special importance during the beginning of cervical dilatation. A cervical dilatation up to 3 cm is faster achieved by cervical relaxation effect and a direct effect on myometrial tissue independant from exterior parameters. The earlier the cervix has reached such a dilatation, the earlier regular contractions are registered at inductions with PGE2. These contractions are furthermore more effective and led to a shorter induction delivery interval under a minimal physiologic stress. This procedure is combined to a lower intrauterine pressure and shows no negative sideeffects on child and mother.

Adult↗
PubMed1973

Harold A. Izant.

Explore the source record for details and available documents.

Developing Countries↗
PubMedDate not supplied

Synthesis and properties of the first all-aza analogue of a biologically active peptide.

The synthesis of the first all-aza-amino acid analogue (2) of a peptidic renin inhibitor is described. The X-ray structural analysis and molecular modelling investigations of this novel compound reveal interesting conformational features which have a significant impact on its biological activity. In addition, insight into conformational features of azapeptides in general in comparison with the corresponding purely peptidic compounds is given.

Aza Compounds↗