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Biomedical subjects

R Weinberg

Publications and source records attributed to R Weinberg.

At least 109 records · Page 6Linked to original sources
PubMed1971

New concepts.

Explore the source record for details and available documents.

Journal Article↗
PubMed1969

The selective interruption of nucleolar RNA synthesis in HeLa cells by cordycepin.

Cordycepin is an analogue of adenosine lacking the 3'-OH. When incorporated into a growing RNA molecule, cordycepin prevents further elongation, thus producing a prematurely terminated RNA molecule. When HeLa cells are exposed to low concentrations of cordycepin, DNA and protein synthesis are unaffected during short exposure periods. The synthesis of completed ribosomal and ribosomal-precursor (45S) RNA is significantly depressed. Partially completed 45S ribosomal precursor molecules accumulate in the nucleolus. 18S ribosomal RNA can be cleaved from these incomplete precursors, while 32S ribosomal precursor cannot be produced from partially snythesized 45S molecules. The synthesis of transfer RNA is also reduced in the presence of cordycepin. The synthesis of the nuclear heterogeneous RNA species is unaffected by the drug while the cytoplasmic heterogeneous RNA is slightly reduced.

Amino Acids↗
PubMedDate not supplied

Subcutaneous low dose arabinosyl-cytosine and oral idarubicin in high risk adult acute myelogenous leukemia.

In order to further explore low dose chemotherapy for high risk acute myelogenous leukemia (AML), low dose Ara-C and oral idarubicin (LAI) were given to 33 patients of 24-84 (median 66) years with AML after myelodysplastic syndrome (MDS) (12 patients), refractory AML (13 patients), and AML with contraindications to intensive chemotherapy (8 patients). Patients received 1 to 4 cycles of Ara-C 10 mg/m2 q 12 h s.c. inject. on days 1-14 and idarubicin 20 mg/m2/d orally days 3, 4, 5. Three Three patients attained complete remission, four patients partial remission and one patient minor response, whereas 11 patients succumbed to early mortality from hemorrhage (two patients) and/or infections (10 patients). Three of 13 patients with heavily pretreated refractory AML went into remission compared to 3/12 with AML after MDS and 1/8 with AML and contraindications against intensive treatment. Median duration of CR is 102 (70-488 +) days. Thirty-two of 33 patients developed grade 4 hematological toxicity requiring platelet transfusions. The non-hematologic toxicity was acceptable. LAI provides a standardized therapeutic option especially for heavily pretreated patients with AML.

Administration, Oral↗
PubMedDate not supplied

A study of oligodontia in a sample of New Orleans children.

From this investigation, the following conclusions can be drawn. The prevalence of oligodontia in 847 New Orleans children was 7.44 +/- .9 percent with a total of 119 teeth absent in sixty-three subjects, excluding third molars. No statistically significant difference in prevalence occurred between the sexes. Difference in bilateral and unilateral tooth absence was not statistically significant. The teeth most frequently absent in decreasing order were the mandibular second premolar, maxillary lateral incisor, and maxillary second premolar. No statistically significant differences occurred in the frequency of absence of the mandibular second premolar and the maxillary lateral incisor. No statistically significant differences occurred in tooth absence for the following comparisons: Maxilla vs mandible . Bilateral vs unilateral . Right vs left.

Adolescent↗