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Biomedical subjects

R Wegmann

Publications and source records attributed to R Wegmann.

At least 73 records · Page 4Linked to original sources
PubMedDate not supplied

[Pharmacokinetic study of 3H-stiripentol in rats (author's transl)].

The radioactive constituents of blood, urine, and bile specimens from Wistar Rats, following intravenous administration of 3H-stiripentol were analyzed, in parallel with samples of: liver, lung, kidneys, testis, heart, brain, cerebellum, and medulla. These investigations yielded the following results: 3H-Stiripentol was quantitatively and rapidly absorbed and metabolized by Wistar rats, due to intense metabolism in the liver. The cerebellum and medulla accumulated radioactivity, which was probably related to the pharmacological effects of this drug.

Animals↗
PubMedDate not supplied

Hyperbaric indices (HBI) assess the extent and timing of deviant blood pressure in patients under treatment.

Fourteen patients provided data from ambulatory monitoring at 7.5-min intervals for 24h. Rhythm characteristics and measures of blood pressure excess (hyperbaric indices along the 24-h scale) are presented in mmHg/h. A 10-year projection of blood pressure excess exceeded the 1,000,000 mmHg/h limit for systolic blood pressure in 4 cases and for diastolic blood pressure in 1 case. In such cases, additional treatment is urgently indicated, whether or not the mean blood pressure is near or even below the limits indicated by current guidelines.

Blood Pressure↗