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Biomedical subjects

R Watanabe

Publications and source records attributed to R Watanabe.

At least 325 records · Page 18Linked to original sources
PubMed1980

In vitro carcinogenesis of hepatocytes obtained from acetylaminofluorene-treated rat liver and promotion of their growth by phenobarbital.

The hepatic cells of rats being fed acetylaminofluorene were transferred into culture at various times. Proliferative hepatocytic foci were obtained from animals treated with the carcinogen for more than 9 weeks. These hepatocytic foci became transplantable and capable of growth in soft agar after 4 to 12 months in culture. Phenobarbital markedly enhanced the growth of these hepatocytes in culture.

2-Acetylaminofluorene↗
PubMed1979

Induction by parathyroid hormone of ornithine decarboxylase in rabbit costal chondrocytes in culture.

The activity of ornithine decarboxylase (ODC) in rabbit costal chondrocytes in culture markedly increased after addition of parathyroid hormone (PTH), reaching a maximum 4 to 5 h after PTH addition. The effect of PTH was dose-dependent both in the presence and absence of fetal calf serum. Addition of cycloheximide or actinomycin D prevented the induction of ODC by PTH. Calcitonin, 1,25-dihydroxyvitamin D3, and vitamin A had no stimulatory effect on the activity of ODC, and did not inhibit the induction of ODC by PTH, when added with PTH.

Animals↗
PubMed1977

[Effects of a proteolytic-enzyme preparation used concomitantly with an antibiotic in osteoarticular infections (author's transl)].

Studies were performed in 8 patients with osteoarticular infections to examine the concentrations of sulbenicillin in the venous blood and exudate following administration and the concentrations of the antibiotic in the exudate when serratiopeptidase was orally administered concomitantly with the antibiotic. The results of the examination indicated that the transfer of sulbenicillin into the exudate tended to increase when 30 mg/day of serratiopeptidase was concomitantly given for 6 days, though further examination was thought necessary by increasing number of subjects and elaborating on the methodology.

Adult↗
PubMed1977

[Postoperative spinal canal stenosis (author's transl)].

Four cases of postoperative spinal canal stenosis were presented in which compression of cauda equina was observed. The lesion was found in 5.8% of operated spinal stenosis (four out of 69 cases). One must pay attention to differentiate the lesion from the recurrence of initial disorder, because the symptoms of the postoperative spinal stenosis is no always typical but sometimes resemble to the symptoms of the initial disorder which needed the operation. Myelography is the only reliable method to decide the extent of the spinal canal stenosis.

Adult↗
PubMed1975

Preparation of perfluorodecalin emulsion, an approach to the red cells substitute.

The major problems unsolved in fluorocarbon emulsions have been the long lasting retention of the substance in tissues of organs and acute shock symptom in animals receiving "coarse" emulsion with particles larger then 0.2 mum. This report offers a new, stable and sterile preparation of 25% "fine" perfluorodecalin emulsion with yolk phospholipid that is eliminated from liver, spleen and other organs within a few weeks, and whose acute and subacute toxicity is as low as perfluorotributylamine/Pluronic F68 emulsion. Effects of the perfluorodecalin emulsion thus prepared for maintaining contractile force of isolated guinea pig heart by perfusion and survival of animals receiving repeated circulatory exchange proved similar to perfluorotributylamine/Pluronic F68 emulsion.

Animals↗
PubMed1975

Measurement of venous blood flow and pressure using thermoelectric and pressure transducers.

In order to simplify procedures for testing the circulatory function of a patient, changes in the venous blood flow as well as venous pressure following exercise were continuously observed using the thermoelectric flowmeter. The level of zero flow necessary for evaluation of the velocity of flow was successfully indicated without occlusion of blood vessels by means of a form of compensation for thermal diffusion devised by the authors.

Blood Flow Velocity↗