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Biomedical subjects

R Walsh

Publications and source records attributed to R Walsh.

At least 91 records · Page 5Linked to original sources
PubMed1982

Collagenase for Peyronie's disease experimental studies.

This pilot study was designed to test the feasibility of using purified clostridial collagenase in the clinical management of Peyronie's disease. The basic properties of this agent are discussed. We studied its effect on Peyronie's plaque tissue by a quantitative in vitro assay utilising the liberation of free alpha-amino groups as an index of enzymatic collagenolysis. Tissue from three patients with Peyronie's disease was used. Tunica albuginea from a second group of three normal patients was studied in the same manner, and no selectivity for the collagen of Peyronie's plaques was identified. Utilising human pericardium as a uniform collagenous substrate, a simple dose-effect relationship was established, and the distribution characteristics of injected collagenase observed. Its effects on blood vessels and nerves in vivo was determined as well as the effects of collagenase on the histology of normal and diseased human tissue in vitro. A tentative dose for use in Peyronie's disease was established, which is discussed in light of existing toxicological data. The study was designed to test the feasibility of purified collagenase in the clinical management of Peyronie's disease. Data included detail plaque digestion and dose-effect relationships in vitro, as well as the histological effects on plaques, blood vessels, and nerves in vivo and in vitro. It is concluded that collagenase may warrant further clinical testing in the treatment of Peyronie's disease.

Animals↗
PubMed1981

ICU nurses rate their work places.

An investigation of 10 critical care units recorded nurses' perceptions of the positive and negative aspects of their work settings.

Attitude of Health Personnel↗
PubMed1981

Sensory environments, brain damage, and drugs: a review of interactions and mediating mechanisms.

The sensory environment appears to play a greater role than was previously appreciated in the etiology of, and recovery from, brain damage. This paper reviews the interaction between brain damage and complex and deprived environments, the nature of mechanisms which may mediate these effects, and the studies of stimulant drug effects on these processes. It is suggested that our traditional concepts of causation and mediating mechanisms have been overly simple and that we need to move to a more holistic multidimensional interactive perspective.

Acetylcholinesterase↗
PubMed1980

The consciousness disciplines and the behavioral sciences: questions of comparison and assessment.

In recent years a number of assessments of the non-Western consciousness disciplines have been undertaken by Western behavioral scientists. The author suggests that a variety of conceptual, methodological, experimential, and content inadequacies render the conclusions of these investigations of doubtful validity. He then describes the models of human nature postulated by these disciplines and the Western behavioral sciences, suggesting that comparing them results in a paradigm clash. The failure to recognize this clash seems to have resulted in inappropriate pathologizing interpretations. Attention is drawn to the relevance of recent findings in state-dependent learning, meditation studies, peak and transcendental experiences, transpersonal psychology, and quantum physics to an assessment of the consciousness disciplines, and suggestions for more adequate investigation are provided.

Behavioral Sciences↗
PubMed1980

The interaction between sensory and nonsensory factors in the determination of brain structure and chemistry: a review.

Contrary to previous thinking, the brain is now recognized as a plastic organ whose structure and function adapt to the functional demands of the sensory environment. This paper examines the interaction between sensory and nonsensory brain-modifying factors in determining the psychobiological outcome in animals reared under conditions of environmental complexity and deprivation. Stimulant drugs appear to enhance complexity effects and depressants to reduce them. Hormones affected by hypophysectomy or castration do not appear to interfere with sensory effects, though a progestogen norethynodrel does appear to interact with them. For genetic effects, strain, species and sex may interact, with male hybrids being perhaps most susceptible to environmental effects. The picture which is emerging is of the brain as inextricably linked to its environment and suggests that a full study demands a recognition of the ecological context. This picture of multiway inter-dependencetrain species and sex may interact, with male hybrids being perhaps most susceptible to environmental effects. The picture which is emerging is of the brain as inextricably linked to its environment and suggests that a full study demands a recognition of the ecological context. This picture of multiway inter-dependencetrain species and sex may interact, with male hybrids being perhaps most susceptible to environmental effects. The picture which is emerging is of the brain as inextricably linked to its environment and suggests that a full study demands a recognition of the ecological context. This picture of multiway inter-dependence and interdetermination or "omnideterminism" is similar to the holistic orgnaismic picture of the universe of the millenia-old yogi-consciousness disciplines and of modern physics.

Animals↗
PubMed1976

Purification of canine plasma renin by affinity chromatography.

An affinity column for the purfication of canine plasma renin was prepared using goat anti-renin (dog kidney) gammaG gloublins. The antiserum was prepared against a purified kidney renin preparation. The anti-renin globulins were coupled to cyanogen bromide activated Sepharose. Using the anti-renin globulin-coupled Sepharose as an immuno-adsorbant, a method was devised allowing purification of plasma renin to a 1,000-fold purity.

Animals↗