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Biomedical subjects

R Wallis

Publications and source records attributed to R Wallis.

40 records · Page 3Linked to original sources
PubMed1975

Effects of prostaglandins of the E-series on pulmonary and systemic circulations of newborn goats during normoxia and hypoxia.

Effects of exogenous prostaglandins of the E-series on pulmonary and systemic circulations of newborn goats were investigated during normoxia and hypoxia. Pulmonary arterial infusion of prostaglandins E1 and E2 decreased pulmonary vascular resistance 20% and 14%, respectively, without systemic effects. Prostaglandin E1 abolished the pulmonary pressor response to hypoxia. Prostaglandin E2 was less effective in counteracting this hypoxic response. The increased pulmonary vascular resistance and augmented response to hypoxia following indomethacin administration was reversed by prostaglandin E1. Infusion of prostaglandin E1 directly into the pulmonary circulation may be of benefit to the distressed newborn with elevated pulmonary vascular resistance.

Animals↗
PubMed1975

The effects of prostaglandin E on fetal pulmonary vascular resistance (38588).

The effects of PGE on pulmonary vascular resistance were investigated in fetal goats using an isolated perfusion technique on otherwise intact unventilated lobes. PGE decreased perfusion pressure in the left pulmonary artery under conditions of monary vascular resistance by vasodilatation of tonically contracted vascular smooth muscle. In our preparation, intrapulmonary PGE infusion did not alter femoral arterial pressure which suggests that PGE is inactivated in the fetal lung. Implications for PGE in the newborn with respiratory distress and increased pulmonary vascular resistance are discussed.

Animals↗
PubMed1975

The effects of indomethacin on the pulmonary vascular response to hypoxia in the premature and mature newborn goat.

The effects of indomethacin on the pulmonary circulation and the response of the circulation to hypoxia were investigated in premature and mature newborns using an isolated perfusion technique on otherwise intact left lungs in situ. There was an increase in pulmonary vascular resistance and augmentation of the increase in pulmonary vascular resistance during hypoxia following indomethacin. These effects were greater in the premature than in the mature newborn. Indomethacin effectively removes a dilator influence on the pulmonary circulation. The results are consistent with the concept that prostaglandins are important in regulating pulmonary vascular resistance.

Animals↗