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Biomedical subjects

R WITMER

Publications and source records attributed to R WITMER.

At least 37 records · Page 2Linked to original sources
PubMed1957

Homologous immunological studies of ocular lens. I. In vitro observations.

Five lens antigens of rabbits can induce antibodies homologously as evidenced by agar precipitin technics. Cross-reactions of lenses of other species (organ specificity) may be due to similarity of varying numbers of these antigens. Newborn and 26-day embryo rabbit lenses seem to have decreased concentrations of, or lack, one antigen present in adult rabbit lens. Streptolysin "O" concentrates appear to act as an adjuvant for homologous lens immunization in rabbits.

Adjuvants, Immunologic↗
PubMed1957

Homologous immunological studies of ocular lens. II. Biological aspects.

Lenses of rabbits with high titers of homologous lens antibodies showed no lesions, even after repeated paracentesis of the anterior chamber in a number of such animals. In these instances, lens antibodies were shown to be present in both the primary and secondary aqueous humors. A small group of rabbits with high homologous anti-lens antibody titers were successfully bred. These had been immunized with adult rabbit lens pools in Freund's adjuvants, and had high antibody levels throughout pregnancy. No significant congenital lens lesions were found when these 18 young from 3 litters were compared with the 17 young from 3 litters of mothers who had no detectable anti-lens antibody through gestation. The latter group of does had received the equivalent doses of homologous lens in saline. Patients with cataract did not show demonstrable anti-lens antibodies in their serum when tested by the agar precipitin technic against cataractous human lens homogenates.

Adult↗