Biomedical subjects
R W Warren
Publications and source records attributed to R W Warren.
Hospitals are saving more than lives--the Texas voluntary effort.
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Hospitals are $aving more than lives--the Texas Voluntary Effort.
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Hospitals are saving more than lives--the Texas voluntary effort.
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Antigen mediation of a late-acting suppressor T-cell activity.
Carrier-specific suppressor T cells can suppress antibody secretion by high avidity IgG plaque-forming cells (PFC) within 90 min in vitro. This process can be blocked by the inclusion of soluble carrier in the cell mixture or by the exposure of target cells to anti-carrier antibodies or pronase. Moreover, suppression can be augmented by PFC exposure to the soluble hapten-carrier conjugate. Finally, carrier specificity may be overcome by preincubation of the target population with a hapten-heterologous carrier before addition of heterologous carrier ATC. Thus, it is likely that high avidity suppression depends upon immunogen bound to the surfaces of antibody-secreting cells which serves as a target for suppressor cells or molecules.
Quantitation of microgram amounts of protein in SDS-mercaptoethanol-tris electrophoresis sample buffer.
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Late acting T cell depression of high avidity IgG antibody secretion in the secondary response.
Activated T lymphocytes (ATC) suppressed the expression of high avidity plaque-forming cells (PFC) in the secondary immune response when given in vivo 1 day before assay or when mixed in vitro with hyperimmune cells for 90 min before assay. This late acting suppression is a cell dose-dependent, carrier-spedific, T cell-mediated phenomenon. The target of this activity if probably the antibody-secreting cell.
Role of t lymphocytes in the humoral immune response. II. T cell-mediated regulation of antibody avidity.
The effect of activated T lymphocytes (ATC) on the avidity distribution of PFC in the secondary response was studied in normal mice. The total PFC response was not significantly changed for either direct or indirect PFC by administration of ATC before secondary antigen challenge. However, marked suppression occurred of indirect PFC that secreted high avidity antibody; no suppression was seen of high avidity direct PFC. At the same time, significant stimulation was seen of relative and absolute frequencies of indirect PFC that secreted middle and low avidity antibody. These effects were dependent on Thy 1-bearing, nylon nonadherent cells which demonstrated carrier specificity. In further characterization of these effects, it was found that increasing the number of ATC transferred produced progressive loss of high avidity PFC and compensatory increase in lower avidity PFC. Moreover, in these experiments, suppression of the high avidity response was inducible with the administration of ATC 5 weeks before to 3 days after the secondary immunization. Thus, it is likely that the avidity-modifying effects are dependent on T lymphocytes which influence the late stages of B lymphocyte maturation.
Ontogeny of immunoglobulin-bearing lymphocytes and DNP-specific antigen-binding cells in guinea pigs.
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A survey of dairy herd rations in Aberdeenshire.
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